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CHICK:PITX2

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0008134

transcription factor binding

PMID:19850024

ECO:0000021

UniProtKB:O93345


F

Figure 1: Possible interaction is observed between Pitx2 and Lef-1

complete

public

GO:0061055

myotome development

PMID:19850024

ECO:0000315

P

Figure 2 and 3 show the gene is clearly involved in myotome development.

complete

public

GO:0061185

negative regulation of dermatome development

PMID:19850024

ECO:0000315

P

Figure 3: Misexpression caused an increased development in the dermatome development suggesting the gene to have a negative effect in vivo.

complete

public

GO:0060174

limb bud formation

PMID:19850024

ECO:0000315

P

Figure 5 shows clear involvement of Pitx2 in the formation of the limb bud.

complete

protected

involved_in

GO:0003007

heart morphogenesis

PMID:10500184

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0001947

heart looping

PMID:10500184

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0032526

response to retinoic acid

PMID:10500184

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:2000288

positive regulation of myoblast proliferation

PMID:19850024

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:2000287

positive regulation of myotome development

PMID:19850024

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0061184

positive regulation of dermatome development

PMID:19850024

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:19850024

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045663

positive regulation of myoblast differentiation

PMID:19850024

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0030326

embryonic limb morphogenesis

PMID:19850024

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007368

determination of left/right symmetry

PMID:9708732

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0043565

sequence-specific DNA binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109340
PANTHER:PTN001551528
WB:WBGene00006766

F

Seeded From UniProt

complete

protected

involved_in

GO:0009653

anatomical structure morphogenesis

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109340
PANTHER:PTN001551528

P

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0020912
MGI:MGI:107374
MGI:MGI:109340
MGI:MGI:1100498
PANTHER:PTN001551528
RGD:3331
RGD:3332
UniProtKB:P78337
UniProtKB:Q99697
WB:WBGene00006766

C

Seeded From UniProt

complete

protected

enables

GO:0001085

RNA polymerase II transcription factor binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001551528
UniProtKB:P78337
UniProtKB:Q99697

F

Seeded From UniProt

complete

protected

enables

GO:0000978

RNA polymerase II proximal promoter sequence-specific DNA binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107374
MGI:MGI:1100498
PANTHER:PTN001551528
RGD:3331

F

Seeded From UniProt

complete

protected

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001356
InterPro:IPR009057

F

Seeded From UniProt

complete

protected

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016233

F

Seeded From UniProt

complete

protected

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017970

P

Seeded From UniProt

complete

protected

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017970

F

Seeded From UniProt

complete

protected

involved_in

GO:0048562

embryonic organ morphogenesis

PMID:10500184

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0003007

heart morphogenesis

PMID:10500184

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

protected

enables

GO:0003677

DNA binding

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238
UniProtKB-KW:KW-0371

F

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete




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