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PMID:25819580
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| Citation |
Nagai, K, Matsushita, T, Matsuzaki, T, Takayama, K, Matsumoto, T, Kuroda, R and Kurosaka, M (2015) Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in human chondrocytes. Osteoarthr. Cartil. 23:1412-20 |
|---|---|
| Abstract |
SIRT6, a member of the sirtuin family of nicotinamide adenine dinucleotide (NAD(+))-dependent protein deacetylases, has been implicated as a key factor in aging-related diseases. However, the role of SIRT6 in chondrocytes has not been fully explored. The purpose of this study was to examine the role of SIRT6 in human chondrocytes by inhibiting SIRT6 in vitro. |
| Links |
PubMed Online version:10.1016/j.joca.2015.03.024 |
| Keywords |
Cell Proliferation; Cells, Cultured; Cellular Senescence; Chondrocytes/metabolism; Chondrocytes/pathology; DNA Damage; Histones/metabolism; Humans; Matrix Metalloproteinase 1/genetics; Matrix Metalloproteinase 1/metabolism; Matrix Metalloproteinase 13/genetics; Matrix Metalloproteinase 13/metabolism; Osteoarthritis, Knee/pathology; RNA Interference; RNA, Messenger/metabolism; Real-Time Polymerase Chain Reaction; Sirtuins/deficiency; Sirtuins/genetics; Telomere; Up-Regulation; beta-Galactosidase/metabolism |
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