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MOUSE:AQP4

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0021591

ventricular system development

PMID:30293570

ECO:0000315

P

Figure 3 shows that AQP4 plays a key role in filling the ventricles with cerebrospinal fluid. Supplemental Material 4B shows that this was not a result of the systematic arterial blood pressure and that it can be inferred that it is caused by AQP4.

complete
CACAO 13362

protected

involved_in

GO:0051289

protein homotetramerization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P55087

P

Seeded From UniProt

complete

public

GO:0033326

cerebrospinal fluid secretion

PMID:30293570

ECO:0000315

P

Figure 5 shows that higher levels of APQ4 can lead to an overloading of CSF in the ventricles since the CSF is not able to flow out of the ventricles. This increases pressure in the ventricles.

Aquaporin-4 as found in uniprot, and AQP4 Mus musculus (Mouse)

complete
CACAO 13364

protected

involved_in

GO:0030104

water homeostasis

PMID:27751903

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0016323

basolateral plasma membrane

PMID:27751903

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0097450

astrocyte end-foot

PMID:22896675

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0090660

cerebrospinal fluid circulation

PMID:22896675

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0009992

cellular water homeostasis

PMID:18286643

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006833

water transport

PMID:18286643

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005887

integral component of plasma membrane

PMID:18286643

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0015250

water channel activity

PMID:18286643

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

part_of

GO:0042383

sarcolemma

PMID:29055082

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0030104

water homeostasis

PMID:8660998

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0016021

integral component of membrane

PMID:8660998

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0015250

water channel activity

PMID:8660998

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

part_of

GO:0005911

cell-cell junction

PMID:18718702

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

PMID:18718702

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:18718702

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0016323

basolateral plasma membrane

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107387
PANTHER:PTN002709547
RGD:2143

C

Seeded From UniProt

complete

protected

part_of

GO:0016021

integral component of membrane

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG13270
FB:FBgn0000180
FB:FBgn0015872
MGI:MGI:103201
PANTHER:PTN000440616
RGD:2143
UniProtKB:P06624

C

Seeded From UniProt

complete

protected

enables

GO:0015250

water channel activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG13270
FB:FBgn0015872
MGI:MGI:107387
MGI:MGI:1096865
MGI:MGI:96990
PANTHER:PTN000440616
RGD:2141
RGD:2143
RGD:3090
UniProtKB:P06624
UniProtKB:P29972
UniProtKB:P30301
UniProtKB:P41181
UniProtKB:P55064
UniProtKB:P55087
UniProtKB:Q5A1Z4
ZFIN:ZDB-GENE-030131-7764
ZFIN:ZDB-GENE-040801-41

F

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG13270
FB:FBgn0000180
MGI:MGI:103201
MGI:MGI:106215
MGI:MGI:107387
MGI:MGI:1096865
MGI:MGI:96990
PANTHER:PTN000440616
RGD:2141
RGD:2142
RGD:2143
RGD:2144
RGD:3090
UniProtKB:K7N7A8
UniProtKB:P06624
UniProtKB:P29972
UniProtKB:P30301
UniProtKB:P41181
UniProtKB:P55064
UniProtKB:P55087
UniProtKB:Q5A1Z4

C

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0071346

cellular response to interferon-gamma

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55087

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0071333

cellular response to glucose stimulus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2143

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0070295

renal water absorption

PMID:10662735

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:103201

P

has_participant:(EMAPA:17373)

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0070295

renal water absorption

PMID:10795927

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857808

P

has_participant:(EMAPA:28346)

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0070295

renal water absorption

PMID:10662735

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857808

P

has_participant:(EMAPA:17373)

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0060354

negative regulation of cell adhesion molecule production

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2143

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0051260

protein homooligomerization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2143

P

Seeded From UniProt

complete

protected

enables

GO:0042802

identical protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55087

F

Seeded From UniProt

complete

protected

part_of

GO:0042383

sarcolemma

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2143

C

Seeded From UniProt

complete

protected

part_of

GO:0032991

protein-containing complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2143

C

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0032715

negative regulation of interleukin-6 production

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2143

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0032691

negative regulation of interleukin-1 beta production

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2143

P

Seeded From UniProt

complete

protected

part_of

GO:0031253

cell projection membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2143

C

Seeded From UniProt

complete

protected

part_of

GO:0030315

T-tubule

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2143

C

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0030104

water homeostasis

PMID:12034763

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857808

P

has_participant:(EMAPA:18231)

Seeded From UniProt

complete

protected

part_of

GO:0016323

basolateral plasma membrane

PMID:21705333

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0016323

basolateral plasma membrane

PMID:21178974

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0016323

basolateral plasma membrane

PMID:10662735

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:28407)
  • part_of:(CL:0005009)|part_of:(EMAPA:29669)
  • part_of:(CL:0000239)

Seeded From UniProt

complete

protected

part_of

GO:0016323

basolateral plasma membrane

PMID:10021464

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32860)
  • part_of:(CL:0000066)

Seeded From UniProt

complete

protected

part_of

GO:0016323

basolateral plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2143

C

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2143

C

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0015670

carbon dioxide transport

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2143

P

Seeded From UniProt

complete

protected

enables

GO:0015288

porin activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2143

F

Seeded From UniProt

complete

protected

enables

GO:0015250

water channel activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55087

F

Seeded From UniProt

complete

protected

enables

GO:0015250

water channel activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2143

F

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0010574

regulation of vascular endothelial growth factor production

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2143

P

Seeded From UniProt

complete

protected

part_of

GO:0009925

basal plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2143

C

Seeded From UniProt

complete

protected

part_of

GO:0009897

external side of plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55087

C

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0007605

sensory perception of sound

PMID:11406631

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857808

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0006833

water transport

PMID:10613915

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857808

P

  • occurs_in:(EMAPA:19000)
  • occurs_in:(CL:0000082)|occurs_in:(EMAPA:36636)
  • occurs_in:(CL:0000082)|occurs_in:(EMAPA:36637)
  • occurs_in:(CL:0000082)|occurs_in:(EMAPA:36638)
  • occurs_in:(CL:0000082)

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0006833

water transport

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2143

P

Seeded From UniProt

complete

protected

part_of

GO:0005911

cell-cell junction

PMID:12673830

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2143

C

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

PMID:16582023

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:32716)
  • part_of:(CL:0000187)

Seeded From UniProt

complete

protected

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55087

C

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P55087

C

Seeded From UniProt

complete

protected

enables

GO:0015267

channel activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000425

F

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000425

C

Seeded From UniProt

complete

protected

involved_in

GO:0055085

transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000425

P

Seeded From UniProt

complete

protected

acts_upstream_of_or_within

GO:0006833

water transport

PMID:11066060

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0005887

integral component of plasma membrane

PMID:11066060

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

protected

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete



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