GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
TableEdit
PMID:1538784
You don't have sufficient rights on this wiki to edit tables. Perhaps you need to log in. Changes you make in the Table editor will not be saved back to the wiki
See Help for Help on this wiki. See the documentation for how to use the table editor
| Citation |
Hagan, I and Yanagida, M (1992) Kinesin-related cut7 protein associates with mitotic and meiotic spindles in fission yeast. Nature 356:74-6 |
|---|---|
| Abstract |
Several mitotic and meiotic gene products are related to the microtubule motor kinesin, providing insight into the molecular basis of the complex motile events responsible for spindle formation and function. Of these genes, three have been shown to affect spindle structure when mutated. The most severe phenotype is seen in Aspergillus nidulans bimC and Schizosaccharomyces pombe cut7 mutants. In both fungi the intranuclear spindle is bipolar, with microtubules that emanate from spindle pole bodies at either pole, interdigitating in a central overlap zone. In bimC and cut7 mutants, microtubule interdigitation does not appear to take place, instead two unconnected half spindles form and chromosome separation fails. Here we report that cut7 protein concentrates on or near the spindle pole bodies throughout mitotic and meiotic nuclear division and associates with mitotic spindle microtubules in a stage-specific manner, associating with the mid-anaphase B midzone. In cut7ts mutants, spindle pole bodies stain but mitotic microtubules do not. |
| Links |
PubMed Online version:10.1038/356074a0 |
| Keywords |
Anaphase/genetics; Aspergillus nidulans/metabolism; Fluorescent Antibody Technique; Fungal Proteins/metabolism; Kinesin/metabolism; Meiosis/genetics; Microtubules/metabolism; Mitosis/genetics; Mutation/genetics; Nuclear Proteins/metabolism; Schizosaccharomyces/metabolism; Spindle Apparatus/metabolism |
| public |
| Cancel |
