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PMID:25660539
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| Citation |
Yuan, S, Zhao, L, Brueckner, M and Sun, Z (2015) Intraciliary calcium oscillations initiate vertebrate left-right asymmetry. Curr. Biol. 25:556-67 |
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| Abstract |
Bilateral symmetry during vertebrate development is broken at the left-right organizer (LRO) by ciliary motility and the resultant directional flow of extracellular fluid. However, how ciliary motility is perceived and transduced into asymmetrical intracellular signaling at the LRO remains controversial. Previous work has indicated that sensory cilia and polycystin-2 (Pkd2), a cation channel, are required for sensing ciliary motility, yet their function and the molecular mechanism linking both to left-right signaling cascades are unknown. |
| Links |
PubMed PMC4469357 Online version:10.1016/j.cub.2014.12.051 |
| Keywords |
ADP-Ribosylation Factors/metabolism; Analysis of Variance; Animals; Body Patterning/physiology; Calcium Signaling/physiology; Cilia/metabolism; Extracellular Fluid/metabolism; Heterotaxy Syndrome/embryology; Histological Techniques; Humans; Models, Biological; Nodal Signaling Ligands/metabolism; Signal Transduction/physiology; TRPP Cation Channels/metabolism; Zebrafish/embryology; Zebrafish Proteins/metabolism |
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