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TableEdit
SCHPO:RAD32
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Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status | |
---|---|---|---|---|---|---|---|---|---|---|---|
public |
GO:0006303 |
double-strand break repair via nonhomologous end joining |
PMID:28292918 |
ECO:0000315 |
P |
Mre11, a protein required for double stranded break repair via non homologous end joining, forms a dimer to bridge the gap between the two broken ends of the double-stranded DNA. Figure 6 proves how dimerization of mre11 ( or rad32 in S. pombe) needs to occur for efficient non homologous end joining since the introduced mutations in the Mre11 dimerization domain, but not the nuclease domain, reduce NHEJ. This data is represented by the drastic decrease in PCR products since the bands for PCR products would indicate successful repair by non homologous end-joining. Therefore, mre11 dimerization is essential for NHEJ since there were no excision products from PCR. |
complete | ||||
protected |
involved_in |
GO:1990918 |
double-strand break repair involved in meiotic recombination |
PMID:15238514 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:1990898 |
meiotic DNA double-strand break clipping |
PMID:19911044 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:1990898 |
meiotic DNA double-strand break clipping |
PMID:19752195 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:1990898 |
meiotic DNA double-strand break clipping |
PMID:19139281 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
part_of |
GO:1990421 |
subtelomeric heterochromatin |
PMID:12196391 |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0072422 |
signal transduction involved in DNA damage checkpoint |
PMID:12944482 |
ECO:0000305 |
curator inference used in manual assertion |
GO:0030870 |
P |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0045027 |
DNA end binding |
PMID:18854158 |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
UniProtKB:Q8U1N9 |
F |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0042769 |
DNA damage response, detection of DNA damage |
PMID:12944482 |
ECO:0000305 |
curator inference used in manual assertion |
GO:0030870 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0042138 |
meiotic DNA double-strand break formation |
PMID:15654094 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
part_of |
GO:0035861 |
site of double-strand break |
PMID:23080121 |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
protected |
part_of |
GO:0035861 |
site of double-strand break |
PMID:21931565 |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
protected |
part_of |
GO:0035861 |
site of double-strand break |
PMID:19804755 |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
protected |
part_of |
GO:0035861 |
site of double-strand break |
PMID:17936710 |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0031573 |
intra-S DNA damage checkpoint |
PMID:12944482 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
part_of |
GO:0030870 |
Mre11 complex |
PMID:22705791 |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
protected |
enables |
GO:0030145 |
manganese ion binding |
PMID:22705791 |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | ||
protected |
enables |
GO:0008311 |
double-stranded DNA 3'-5' exodeoxyribonuclease activity |
PMID:9651580 |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
UniProtKB:P49959 |
F |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0008310 |
single-stranded DNA 3'-5' exodeoxyribonuclease activity |
PMID:9651580 |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
UniProtKB:P49959 |
F |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0007131 |
reciprocal meiotic recombination |
PMID:7885834 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0006303 |
double-strand break repair via nonhomologous end joining |
PMID:10373582 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0006302 |
double-strand break repair |
PMID:7885834 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
enables |
GO:0004518 |
nuclease activity |
PMID:22705791 |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | ||
protected |
part_of |
GO:0000784 |
nuclear chromosome, telomeric region |
PMID:12861005 |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0000729 |
DNA double-strand break processing |
PMID:23080121 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0000729 |
DNA double-strand break processing |
PMID:21931565 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
part_of:(GO:0000724) |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0000724 |
double-strand break repair via homologous recombination |
PMID:12628934 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0000723 |
telomere maintenance |
PMID:12861005 |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
PomBase:SPAC16A10.07c |
P |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0000403 |
Y-form DNA binding |
PMID:18854158 |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
UniProtKB:Q8U1N9 |
F |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0000014 |
single-stranded DNA endodeoxyribonuclease activity |
PMID:9651580 |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
UniProtKB:P49959 |
F |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0097552 |
mitochondrial double-strand break repair via homologous recombination |
PMID:21873635 |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000015644 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0042138 |
meiotic DNA double-strand break formation |
PMID:21873635 |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000015644 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0031573 |
intra-S DNA damage checkpoint |
PMID:21873635 |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1100512 |
P |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0008408 |
3'-5' exonuclease activity |
PMID:21873635 |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002228124 |
F |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0008296 |
3'-5'-exodeoxyribonuclease activity |
PMID:21873635 |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002228124 |
F |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0007095 |
mitotic G2 DNA damage checkpoint |
PMID:21873635 |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0020270 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0006303 |
double-strand break repair via nonhomologous end joining |
PMID:21873635 |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000015644 |
P |
Seeded From UniProt |
complete | |
protected |
colocalizes_with |
GO:0000784 |
nuclear chromosome, telomeric region |
PMID:21873635 |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1100512 |
C |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0000724 |
double-strand break repair via homologous recombination |
PMID:21873635 |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000015644 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0000723 |
telomere maintenance |
PMID:21873635 |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0020270 |
P |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0004519 |
endonuclease activity |
GO_REF:0000002 |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR003701 |
F |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0005634 |
nucleus |
GO_REF:0000002 |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR007281 |
C |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0006302 |
double-strand break repair |
GO_REF:0000002 |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR003701 |
P |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0008408 |
3'-5' exonuclease activity |
GO_REF:0000002 |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR003701 |
F |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0016787 |
hydrolase activity |
GO_REF:0000002 |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR004843 |
F |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0030145 |
manganese ion binding |
GO_REF:0000002 |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR007281 |
F |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0030870 |
Mre11 complex |
GO_REF:0000002 |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR003701 |
C |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0004518 |
nuclease activity |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0540 |
F |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0004527 |
exonuclease activity |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0269 |
F |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0016787 |
hydrolase activity |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0378 |
F |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0006281 |
DNA repair |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0234 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0006974 |
cellular response to DNA damage stimulus |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0227 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0051321 |
meiotic cell cycle |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0469 |
P |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0004519 |
endonuclease activity |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0255 |
F |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0005634 |
nucleus |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0539 |
C |
Seeded From UniProt |
complete |
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