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SCHPO:RAD32

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0006303

double-strand break repair via nonhomologous end joining

PMID:28292918

ECO:0000315

P

Mre11, a protein required for double stranded break repair via non homologous end joining, forms a dimer to bridge the gap between the two broken ends of the double-stranded DNA. Figure 6 proves how dimerization of mre11 ( or rad32 in S. pombe) needs to occur for efficient non homologous end joining since the introduced mutations in the Mre11 dimerization domain, but not the nuclease domain, reduce NHEJ. This data is represented by the drastic decrease in PCR products since the bands for PCR products would indicate successful repair by non homologous end-joining. Therefore, mre11 dimerization is essential for NHEJ since there were no excision products from PCR.

complete
CACAO 12476

protected

involved_in

GO:1990918

double-strand break repair involved in meiotic recombination

PMID:15238514

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:1990898

meiotic DNA double-strand break clipping

PMID:19911044

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:1990898

meiotic DNA double-strand break clipping

PMID:19752195

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:1990898

meiotic DNA double-strand break clipping

PMID:19139281

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:1990421

subtelomeric heterochromatin

PMID:12196391

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0072422

signal transduction involved in DNA damage checkpoint

PMID:12944482

ECO:0000305

curator inference used in manual assertion

GO:0030870

P

Seeded From UniProt

complete

protected

enables

GO:0045027

DNA end binding

PMID:18854158

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8U1N9

F

Seeded From UniProt

complete

protected

involved_in

GO:0042769

DNA damage response, detection of DNA damage

PMID:12944482

ECO:0000305

curator inference used in manual assertion

GO:0030870

P

Seeded From UniProt

complete

protected

involved_in

GO:0042138

meiotic DNA double-strand break formation

PMID:15654094

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0035861

site of double-strand break

PMID:23080121

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0035861

site of double-strand break

PMID:21931565

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0035861

site of double-strand break

PMID:19804755

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0035861

site of double-strand break

PMID:17936710

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0031573

intra-S DNA damage checkpoint

PMID:12944482

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

part_of

GO:0030870

Mre11 complex

PMID:22705791

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

enables

GO:0030145

manganese ion binding

PMID:22705791

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0008311

double-stranded DNA 3'-5' exodeoxyribonuclease activity

PMID:9651580

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P49959

F

Seeded From UniProt

complete

protected

enables

GO:0008310

single-stranded DNA 3'-5' exodeoxyribonuclease activity

PMID:9651580

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P49959

F

Seeded From UniProt

complete

protected

involved_in

GO:0007131

reciprocal meiotic recombination

PMID:7885834

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006303

double-strand break repair via nonhomologous end joining

PMID:10373582

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0006302

double-strand break repair

PMID:7885834

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0004518

nuclease activity

PMID:22705791

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

part_of

GO:0000784

nuclear chromosome, telomeric region

PMID:12861005

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0000729

DNA double-strand break processing

PMID:23080121

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0000729

DNA double-strand break processing

PMID:21931565

ECO:0000315

mutant phenotype evidence used in manual assertion

P

part_of:(GO:0000724)

Seeded From UniProt

complete

protected

involved_in

GO:0000724

double-strand break repair via homologous recombination

PMID:12628934

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0000723

telomere maintenance

PMID:12861005

ECO:0000316

genetic interaction evidence used in manual assertion

PomBase:SPAC16A10.07c

P

Seeded From UniProt

complete

protected

enables

GO:0000403

Y-form DNA binding

PMID:18854158

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q8U1N9

F

Seeded From UniProt

complete

protected

enables

GO:0000014

single-stranded DNA endodeoxyribonuclease activity

PMID:9651580

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P49959

F

Seeded From UniProt

complete

protected

involved_in

GO:0097552

mitochondrial double-strand break repair via homologous recombination

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000015644
SGD:S000004837

P

Seeded From UniProt

complete

protected

involved_in

GO:0042138

meiotic DNA double-strand break formation

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000015644
PomBase:SPAC13C5.07

P

Seeded From UniProt

complete

protected

involved_in

GO:0031573

intra-S DNA damage checkpoint

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1100512
PANTHER:PTN000015646
PomBase:SPAC13C5.07

P

Seeded From UniProt

complete

protected

enables

GO:0008408

3'-5' exonuclease activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002228124
SGD:S000004837
UniProtKB:P49959

F

Seeded From UniProt

complete

protected

enables

GO:0008296

3'-5'-exodeoxyribonuclease activity

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002228124
SGD:S000004837

F

Seeded From UniProt

complete

protected

involved_in

GO:0007095

mitotic G2 DNA damage checkpoint

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0020270
MGI:MGI:1100512
PANTHER:PTN000015644

P

Seeded From UniProt

complete

protected

involved_in

GO:0006303

double-strand break repair via nonhomologous end joining

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000015644
PomBase:SPAC13C5.07
SGD:S000004837
UniProtKB:P49959

P

Seeded From UniProt

complete

protected

colocalizes_with

GO:0000784

nuclear chromosome, telomeric region

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1100512
PANTHER:PTN000015644
PomBase:SPAC13C5.07
UniProtKB:P49959

C

Seeded From UniProt

complete

protected

involved_in

GO:0000724

double-strand break repair via homologous recombination

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000015644
PomBase:SPAC13C5.07
SGD:S000004837
UniProtKB:P49959

P

Seeded From UniProt

complete

protected

involved_in

GO:0000723

telomere maintenance

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0020270
PANTHER:PTN000015644
PomBase:SPAC13C5.07
SGD:S000004837
UniProtKB:P49959

P

Seeded From UniProt

complete

protected

enables

GO:0004519

endonuclease activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003701
InterPro:IPR007281

F

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007281

C

Seeded From UniProt

complete

protected

involved_in

GO:0006302

double-strand break repair

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003701
InterPro:IPR007281

P

Seeded From UniProt

complete

protected

enables

GO:0008408

3'-5' exonuclease activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003701

F

Seeded From UniProt

complete

protected

enables

GO:0016787

hydrolase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004843

F

Seeded From UniProt

complete

protected

enables

GO:0030145

manganese ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007281

F

Seeded From UniProt

complete

protected

part_of

GO:0030870

Mre11 complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003701

C

Seeded From UniProt

complete

protected

enables

GO:0004518

nuclease activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0540

F

Seeded From UniProt

complete

protected

enables

GO:0004527

exonuclease activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0269

F

Seeded From UniProt

complete

protected

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

protected

involved_in

GO:0006281

DNA repair

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0234

P

Seeded From UniProt

complete

protected

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

protected

involved_in

GO:0051321

meiotic cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0469

P

Seeded From UniProt

complete

protected

enables

GO:0004519

endonuclease activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0255

F

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete




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