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HUMAN:DND1

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0061158

3'-UTR-mediated mRNA destabilization

PMID:28297718

ECO:0000314

P

Organism: Homo sapiens. UniProt’s Name: Dead end protein homolog 1. Paper’s Name: RNA-binding protein DND1. Notes: Extended Figure 2g is primarily used, though other figures help to understand the findings. For instance, the paper had previously indicated that DND1 is responsible for mRNA destabilization, and showed in Figure 1E that with an increase in number of DND1 binding sites lead to a greater decrease in median transcript abundance. More importantly, the paper states that “only binding sites located in the 3′ UTR contributed to the DND1-mediated target mRNA reduction.” Extended Figure 2g indeed shows that mRNA targets (of DND1) with binding sites in the 3’-UTR region also have a greater decrease in median transcript abundance. As this data primarily makes use of “FH–DND1-expressing HEK293 cells,” this is a human protein, not a mouse protein.

complete
CACAO 12373

protected

involved_in

GO:0060965

negative regulation of gene silencing by miRNA

PMID:18155131

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

NOT|enables

GO:0035198

miRNA binding

PMID:18155131

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

enables

GO:0003730

mRNA 3'-UTR binding

PMID:18155131

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:18155131

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:18155131

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

protected

involved_in

GO:0060965

negative regulation of gene silencing by miRNA

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002723154
UniProtKB:Q8IYX4

P

Seeded From UniProt

complete

protected

involved_in

GO:0048255

mRNA stabilization

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002723154
ZFIN:ZDB-GENE-030828-4

P

Seeded From UniProt

complete

protected

enables

GO:0017091

AU-rich element binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002723154
UniProtKB:Q8IYX4

F

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2447763
PANTHER:PTN002723154
UniProtKB:F1RGE0
UniProtKB:Q8IYX4
ZFIN:ZDB-GENE-030828-4

C

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1891690
MGI:MGI:1891692
MGI:MGI:1917115
MGI:MGI:2384294
MGI:MGI:3645057
PANTHER:PTN002723140
RGD:1305683
RGD:619834
RGD:631348
UniProtKB:A0A0B4KHI4
UniProtKB:F1RGE0
UniProtKB:O43390
UniProtKB:O60506
UniProtKB:Q8IYX4
UniProtKB:Q9NQ94
WB:WBGene00002000
ZFIN:ZDB-GENE-030828-4

C

Seeded From UniProt

complete

protected

enables

GO:0003729

mRNA binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002723140
RGD:1305683
RGD:619834
RGD:631348
UniProtKB:A0A0B4KHI4
UniProtKB:F1RGE0
ZFIN:ZDB-GENE-030828-4
ZFIN:ZDB-GENE-040426-2766

F

Seeded From UniProt

complete

protected

enables

GO:0003723

RNA binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1891690
MGI:MGI:2384294
MGI:MGI:3645057
PANTHER:PTN002723139
RGD:1305683
RGD:619834
RGD:631348
UniProtKB:A0A0B4KHI4
UniProtKB:F1RGE0
UniProtKB:Q8IYX4
UniProtKB:Q9NQ94
ZFIN:ZDB-GENE-030828-4
ZFIN:ZDB-GENE-040426-2766

F

Seeded From UniProt

complete

protected

involved_in

GO:0007281

germ cell development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6VY05
ensembl:ENSMUSP00000054412

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6VY05
ensembl:ENSMUSP00000054412

C

Seeded From UniProt

complete

protected

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000504
InterPro:IPR035979

F

Seeded From UniProt

complete

protected

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

protected

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

protected

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete




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