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TableEdit
HUMAN:DND1
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Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status | |
---|---|---|---|---|---|---|---|---|---|---|---|
public |
GO:0061158 |
3'-UTR-mediated mRNA destabilization |
PMID:28297718 |
ECO:0000314 |
P |
Organism: Homo sapiens. UniProt’s Name: Dead end protein homolog 1. Paper’s Name: RNA-binding protein DND1. Notes: Extended Figure 2g is primarily used, though other figures help to understand the findings. For instance, the paper had previously indicated that DND1 is responsible for mRNA destabilization, and showed in Figure 1E that with an increase in number of DND1 binding sites lead to a greater decrease in median transcript abundance. More importantly, the paper states that “only binding sites located in the 3′ UTR contributed to the DND1-mediated target mRNA reduction.” Extended Figure 2g indeed shows that mRNA targets (of DND1) with binding sites in the 3’-UTR region also have a greater decrease in median transcript abundance. As this data primarily makes use of “FH–DND1-expressing HEK293 cells,” this is a human protein, not a mouse protein. |
complete | ||||
protected |
involved_in |
GO:0060965 |
negative regulation of gene silencing by miRNA |
PMID:18155131 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
NOT|enables |
GO:0035198 |
miRNA binding |
PMID:18155131 |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | ||
protected |
enables |
GO:0003730 |
mRNA 3'-UTR binding |
PMID:18155131 |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | ||
protected |
part_of |
GO:0005737 |
cytoplasm |
PMID:18155131 |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
protected |
part_of |
GO:0005634 |
nucleus |
PMID:18155131 |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0060965 |
negative regulation of gene silencing by miRNA |
PMID:21873635 |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002723154 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0048255 |
mRNA stabilization |
PMID:21873635 |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002723154 |
P |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0017091 |
AU-rich element binding |
PMID:21873635 |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002723154 |
F |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0005737 |
cytoplasm |
PMID:21873635 |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2447763 |
C |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0005634 |
nucleus |
PMID:21873635 |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1891690 |
C |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0003729 |
mRNA binding |
PMID:21873635 |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002723140 |
F |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0003723 |
RNA binding |
PMID:21873635 |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1891690 |
F |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0007281 |
germ cell development |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q6VY05 |
P |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0005737 |
cytoplasm |
GO_REF:0000107 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q6VY05 |
C |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0003676 |
nucleic acid binding |
GO_REF:0000002 |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000504 |
F |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0003723 |
RNA binding |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0694 |
F |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0005634 |
nucleus |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0539 |
C |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0007275 |
multicellular organism development |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0217 |
P |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0005737 |
cytoplasm |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0963 |
C |
Seeded From UniProt |
complete |
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