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HUMAN:ASXL3

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0051055

negative regulation of lipid biosynthetic process

PMID:25450400

ECO:0000314

P

As shown in Fig. 4E, ASXL3 overexpression reduced intracellular lipid deposition. This data suggests that ASXL3 negatively regulates lipogenesis by repressing the transcriptional activity of LXRα, a key mediator of lipogenesis in the liver.

complete
CACAO 11256

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2684063
PANTHER:PTN000339786
UniProtKB:Q76L83

P

Seeded From UniProt

complete

protected

enables

GO:0042975

peroxisome proliferator activated receptor binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2684063
PANTHER:PTN000339788
UniProtKB:Q76L83

F

Seeded From UniProt

complete

protected

part_of

GO:0035517

PR-DUB complex

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0261823
PANTHER:PTN000339786
UniProtKB:Q8IXJ9

C

Seeded From UniProt

complete

protected

involved_in

GO:0009887

animal organ morphogenesis

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2684063
PANTHER:PTN000339786

P

Seeded From UniProt

complete

protected

colocalizes_with

GO:0005634

nucleus

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0261823
MGI:MGI:1922552
MGI:MGI:2684063
PANTHER:PTN000339786

C

Seeded From UniProt

complete

protected

enables

GO:0003682

chromatin binding

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0261823
PANTHER:PTN000339786

F

Seeded From UniProt

complete

protected

colocalizes_with

GO:0000790

nuclear chromatin

PMID:21873635

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1922552
PANTHER:PTN000339786

C

Seeded From UniProt

complete

protected

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR026905

F

Seeded From UniProt

complete

protected

involved_in

GO:0006351

transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007759

P

Seeded From UniProt

complete

protected

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007759

P

Seeded From UniProt

complete

protected

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

protected

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete




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