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HPV16:VE6

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Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

public

GO:0030165

PDZ domain binding

PMID:21139582

ECO:0000021

UniProtKB:O14907 UniProtKB:P03126


F

Binding of HPV E6 and Tip-I’s PDZ domain is shown in: Figure 1 (A) Yeast mating assay confirming that HPV16 E6 binds to short carboxyl terminal of Tip-I’ PDZ domain. The abstract and introduction explain in more detail and make reference to the original paper for these findings (Hampson et al, 2004)

complete

public

GO:0043088

regulation of Cdc42 GTPase activity

PMID:21139582

ECO:0000314

P

Fluorescent kinetic analysis of Cdc42 activation by GEF16 in the presence of high-risk HPV16 E6 and Tip-1. Different combinations of 2 mM concentrations of the recombinant proteins GEF16, Tip-1 and HPV16 E6 were added after 4 min of initial readings being taken with Cdc42 and assay buffers alone. Each combination was carried out in triplicate. It can be seen that Cdc42 activation by GEF16 is enhanced in the presence of Tip-1 and E6. HPV16 E6, Tip-1, ARHGEF16 and Cdc42 activation

complete

public

GO:0035023

regulation of Rho protein signal transduction

PMID:21139582

ECO:0000314

P

Figure 3 Expression of HPV16 E6 is associated with the upregulation of GEF16 and higher levels of activated Cdc42 in non-transformed cells.Fig3(C) Western immunoblot analysis of GTP-activated Cdc42 in HPV16 E6- and HPV6 E6-transfected hTert cells. hTertT16 E6 cells showed increased levels of activated Cdc42. The addition of GTP to the PAK1 Cdc42 assay shows constitutive GTP activation of the available Cdc42.

complete

public

GO:0045892

negative regulation of transcription, DNA-dependent

PMID:10400710

ECO:0000315

P

Figure 7. HPV-16 E6 represses the ability of CBP to activate p53-dependent transcription.

complete
CACAO 8543

public

GO:0039653

suppression by virus of host transcription

PMID:10400710

ECO:0000315

P

Figure 7

complete
CACAO 8571

public

GO:0039653

suppression by virus of host transcription

1040071:1040071

ECO:0000314

P

Figure 6. 16E6 protein can disrupt an in vitro p53-CBP interaction in in a dose-dependent manner

complete
CACAO 8574

protected

involved_in

GO:0039653

suppression by virus of host transcription

PMID:10400710

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21139582

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

involved_in

GO:0090630

activation of GTPase activity

PMID:21139582

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

protected

enables

GO:0030165

PDZ domain binding

PMID:21139582

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O14907

F

Seeded From UniProt

complete

protected

enables

GO:0042802

identical protein binding

PMID:22483108

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P03126

F

Seeded From UniProt

complete

protected

part_of

GO:0042025

host cell nucleus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001334

C

Seeded From UniProt

complete

protected

involved_in

GO:0039502

suppression by virus of host type I interferon-mediated signaling pathway

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000496164

P

Seeded From UniProt

complete

protected

involved_in

GO:0006351

transcription, DNA-templated

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000496164

P

Seeded From UniProt

complete

protected

enables

GO:0046872

metal ion binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000496164

F

Seeded From UniProt

complete

protected

enables

GO:0003677

DNA binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000496164

F

Seeded From UniProt

complete

protected

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000496164

P

Seeded From UniProt

complete

protected

involved_in

GO:0039649

modulation by virus of host ubiquitin-protein ligase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000496164

P

Seeded From UniProt

complete

protected

enables

GO:0030165

PDZ domain binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000496164

F

Seeded From UniProt

complete

protected

involved_in

GO:0039548

suppression by virus of host IRF3 activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000496164

P

Seeded From UniProt

complete

protected

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

protected

part_of

GO:0030430

host cell cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1035
UniProtKB-SubCell:SL-0381

C

Seeded From UniProt

complete

protected

involved_in

GO:0039548

suppression by virus of host IRF3 activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1092

P

Seeded From UniProt

complete

protected

involved_in

GO:0039526

modulation by virus of host apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1119

P

Seeded From UniProt

complete

protected

involved_in

GO:0039503

suppression by virus of host innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1090

P

Seeded From UniProt

complete

protected

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

protected

involved_in

GO:0030683

evasion or tolerance by virus of host immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0899

P

Seeded From UniProt

complete

protected

part_of

GO:0042025

host cell nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1048
UniProtKB-SubCell:SL-0414

C

Seeded From UniProt

complete

protected

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete




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