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TableEdit
HPV16:VE6
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Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status | |
---|---|---|---|---|---|---|---|---|---|---|---|
public |
GO:0030165 |
PDZ domain binding |
PMID:21139582 |
ECO:0000021 |
UniProtKB:O14907 UniProtKB:P03126
|
F |
Binding of HPV E6 and Tip-I’s PDZ domain is shown in: Figure 1 (A) Yeast mating assay confirming that HPV16 E6 binds to short carboxyl terminal of Tip-I’ PDZ domain. The abstract and introduction explain in more detail and make reference to the original paper for these findings (Hampson et al, 2004) |
complete | |||
public |
GO:0043088 |
regulation of Cdc42 GTPase activity |
PMID:21139582 |
ECO:0000314 |
P |
Fluorescent kinetic analysis of Cdc42 activation by GEF16 in the presence of high-risk HPV16 E6 and Tip-1. Different combinations of 2 mM concentrations of the recombinant proteins GEF16, Tip-1 and HPV16 E6 were added after 4 min of initial readings being taken with Cdc42 and assay buffers alone. Each combination was carried out in triplicate. It can be seen that Cdc42 activation by GEF16 is enhanced in the presence of Tip-1 and E6. HPV16 E6, Tip-1, ARHGEF16 and Cdc42 activation |
complete | ||||
public |
GO:0035023 |
regulation of Rho protein signal transduction |
PMID:21139582 |
ECO:0000314 |
P |
Figure 3 Expression of HPV16 E6 is associated with the upregulation of GEF16 and higher levels of activated Cdc42 in non-transformed cells.Fig3(C) Western immunoblot analysis of GTP-activated Cdc42 in HPV16 E6- and HPV6 E6-transfected hTert cells. hTertT16 E6 cells showed increased levels of activated Cdc42. The addition of GTP to the PAK1 Cdc42 assay shows constitutive GTP activation of the available Cdc42. |
complete | ||||
public |
GO:0045892 |
negative regulation of transcription, DNA-dependent |
PMID:10400710 |
ECO:0000315 |
P |
Figure 7. HPV-16 E6 represses the ability of CBP to activate p53-dependent transcription. |
complete | ||||
public |
GO:0039653 |
suppression by virus of host transcription |
PMID:10400710 |
ECO:0000315 |
P |
Figure 7 |
complete | ||||
public |
GO:0039653 |
suppression by virus of host transcription |
1040071:1040071 |
ECO:0000314 |
P |
Figure 6. 16E6 protein can disrupt an in vitro p53-CBP interaction in in a dose-dependent manner |
complete | ||||
protected |
involved_in |
GO:0039653 |
suppression by virus of host transcription |
PMID:10400710 |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
PMID:21139582 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
involved_in |
GO:0090630 |
activation of GTPase activity |
PMID:21139582 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
protected |
enables |
GO:0030165 |
PDZ domain binding |
PMID:21139582 |
ECO:0000353 |
physical interaction evidence used in manual assertion |
UniProtKB:O14907 |
F |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0042802 |
identical protein binding |
PMID:22483108 |
ECO:0000353 |
physical interaction evidence used in manual assertion |
UniProtKB:P03126 |
F |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0042025 |
host cell nucleus |
GO_REF:0000002 |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001334 |
C |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0039502 |
suppression by virus of host type I interferon-mediated signaling pathway |
GO_REF:0000104 |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000496164 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0006351 |
transcription, DNA-templated |
GO_REF:0000104 |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000496164 |
P |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0046872 |
metal ion binding |
GO_REF:0000104 |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000496164 |
F |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0003677 |
DNA binding |
GO_REF:0000104 |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000496164 |
F |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
GO_REF:0000104 |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000496164 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0039649 |
modulation by virus of host ubiquitin-protein ligase activity |
GO_REF:0000104 |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000496164 |
P |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0030165 |
PDZ domain binding |
GO_REF:0000104 |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000496164 |
F |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0039548 |
suppression by virus of host IRF3 activity |
GO_REF:0000104 |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000496164 |
P |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0003677 |
DNA binding |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0238 |
F |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0030430 |
host cell cytoplasm |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-1035 |
C |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0039548 |
suppression by virus of host IRF3 activity |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-1092 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0039526 |
modulation by virus of host apoptotic process |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-1119 |
P |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0039503 |
suppression by virus of host innate immune response |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-1090 |
P |
Seeded From UniProt |
complete | |
protected |
enables |
GO:0046872 |
metal ion binding |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0479 |
F |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0030683 |
evasion or tolerance by virus of host immune response |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0899 |
P |
Seeded From UniProt |
complete | |
protected |
part_of |
GO:0042025 |
host cell nucleus |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-1048 |
C |
Seeded From UniProt |
complete | |
protected |
involved_in |
GO:0016032 |
viral process |
GO_REF:0000037 |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0945 |
P |
Seeded From UniProt |
complete |
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