GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

YEAST:YPK1

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s) YPK1 (synonyms: SLI2)
Protein Name(s) Serine/threonine-protein kinase YPK1

Sphingosine-like immunosuppressant resistant protein 2 Yeast protein kinase 1

External Links
UniProt P12688
EMBL M21307
Z28126
BK006944
PIR S37955
RefSeq NP_012796.1
ProteinModelPortal P12688
SMR P12688
BioGrid 34010
DIP DIP-4869N
IntAct P12688
MINT MINT-505912
STRING 4932.YKL126W
MaxQB P12688
PaxDb P12688
PeptideAtlas P12688
EnsemblFungi [example_ID YKL126W]
GeneID 853733
KEGG sce:YKL126W
CYGD YKL126w
SGD S000001609
eggNOG COG0515
GeneTree ENSGT00770000120449
HOGENOM HOG000233033
InParanoid P12688
KO K13303
OrthoDB EOG7R2BT5
BioCyc YEAST:G3O-31908-MONOMER
BRENDA 2.7.11.1
NextBio 974775
Proteomes UP000002311
Genevestigator P12688
GO GO:0005935
GO:0005829
GO:0005886
GO:0005524
GO:0004674
GO:0071555
GO:0070941
GO:0006897
GO:0006650
GO:0061093
GO:0090157
GO:0046777
GO:0006468
InterPro IPR000961
IPR011009
IPR017892
IPR000719
IPR017441
IPR002290
IPR008271
Pfam PF00069
PF00433
SMART SM00133
SM00220
SUPFAM SSF56112
PROSITE PS51285
PS00107
PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0071311

cellular response to acetate

PMID:27671892[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060237

regulation of fungal-type cell wall organization

PMID:12221112[2]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000003631,SGD:S000004710

P

Seeded From UniProt

complete

involved_in

GO:0060237

regulation of fungal-type cell wall organization

PMID:12221112[2]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000000201,SGD:S000004710

P

Seeded From UniProt

complete

involved_in

GO:0060237

regulation of fungal-type cell wall organization

PMID:12221112[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

GO:0019887

protein kinase regulator activity

PMID:22080611[3]

ECO:0000315

F

Figure 1C

complete
CACAO 2851

involved_in

GO:0060237

regulation of fungal-type cell wall organization

PMID:12221112[2]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000004710

P

Seeded From UniProt

complete

involved_in

GO:0018105

peptidyl-serine phosphorylation

PMID:26582391[4]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000000232,SGD:S000004710

P

  • has_input:(SGD:S000006011)
  • has_input:(SGD:S000000385)

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:26274562[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

has_direct_input:(UniProtKB:P23900)

Seeded From UniProt

complete

enables

GO:0019887

protein kinase regulator activity

PMID:22080611[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000749

response to pheromone triggering conjugation with cellular fusion

PMID:25378585[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090155

negative regulation of sphingolipid biosynthetic process

PMID:22080611[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:22080611[3]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(UniProtKB:Q06144)

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:22080611[3]

ECO:0000314

direct assay evidence used in manual assertion

F

has_direct_input:(UniProtKB:P53224)|has_direct_input:(UniProtKB:Q06144)

Seeded From UniProt

complete

involved_in

GO:0006650

glycerophospholipid metabolic process

PMID:25258318[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006650

glycerophospholipid metabolic process

PMID:25258318[7]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P39105

P

Seeded From UniProt

complete

involved_in

GO:0070941

eisosome assembly

PMID:18296441[8]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000004710

P

Seeded From UniProt

complete

involved_in

GO:0061093

negative regulation of phospholipid translocation

PMID:19966303[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046777

protein autophosphorylation

PMID:19966303[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:19966303[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:10825204[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:19966303[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005935

cellular bud neck

PMID:10825204[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:10825204[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:10825204[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:12221112[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:10825204[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:19966303[9]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003744
FB:FBgn0010379
MGI:MGI:97601
PANTHER:PTN000683254
PomBase:SPAC1B9.02c
PomBase:SPAC22E12.14c
PomBase:SPAPB18E9.02c
RGD:3395
RGD:3399
RGD:61925
RGD:620968
RGD:67383
SGD:S000000201
UniProtKB:O15530
UniProtKB:P31749
UniProtKB:Q15208
UniProtKB:Q9NRM7
UniProtKB:Q9Y2H1

P

Seeded From UniProt

complete

involved_in

GO:0018105

peptidyl-serine phosphorylation

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:87986
PANTHER:PTN000683254
RGD:2081
RGD:3395
RGD:3399
RGD:3668
RGD:61925
SGD:S000001609
SGD:S000001861
SGD:S000002898
SGD:S000005460
UniProtKB:A0A1D5PUY5
UniProtKB:P31749
UniProtKB:P41743
UniProtKB:Q02156
UniProtKB:Q05513
UniProtKB:Q05655
WB:WBGene00000102
WB:WBGene00000103
WB:WBGene00004033
WB:WBGene00004034
WB:WBGene00004789
WB:WBGene00006599

P

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:21873635[11]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003091
FB:FBgn0003744
FB:FBgn0010379
FB:FBgn0260399
FB:FBgn0261854
MGI:MGI:104874
MGI:MGI:2182368
MGI:MGI:87986
MGI:MGI:894676
MGI:MGI:97595
MGI:MGI:97596
MGI:MGI:97599
MGI:MGI:97602
PANTHER:PTN000683254
PomBase:SPAC1B9.02c
PomBase:SPAC22E12.14c
PomBase:SPAC24B11.11c
PomBase:SPAC821.12
PomBase:SPAPB18E9.02c
PomBase:SPCC576.15c
RGD:2081
RGD:2082
RGD:3399
RGD:3668
RGD:620146
RGD:620968
RGD:62390
SGD:S000001248
SGD:S000001609
SGD:S000001861
SGD:S000002898
SGD:S000003324
SGD:S000005105
SGD:S000005460
SGD:S000006315
TAIR:locus:2088515
UniProtKB:O15530
UniProtKB:O95835
UniProtKB:P05771
UniProtKB:P17252
UniProtKB:P31749
UniProtKB:P31751
UniProtKB:P41743
UniProtKB:Q02156
UniProtKB:Q04759
UniProtKB:Q05513
UniProtKB:Q05655
UniProtKB:Q09013
UniProtKB:Q15208
UniProtKB:Q16512
UniProtKB:Q16513
UniProtKB:Q96GX5
UniProtKB:Q9NRM7
UniProtKB:Q9XF67
UniProtKB:Q9Y243
UniProtKB:Q9Y2H1
WB:WBGene00000102
WB:WBGene00000103
WB:WBGene00004034
WB:WBGene00004789
WB:WBGene00006599
dictyBase:DDB_G0268620

F

Seeded From UniProt

complete

involved_in

GO:0045859

regulation of protein kinase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0019887

P

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000961
InterPro:IPR017892

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR000961
InterPro:IPR017441
InterPro:IPR017892

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR000961
InterPro:IPR008271
InterPro:IPR017892

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0006897

endocytosis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0254

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

involved_in

GO:0071555

cell wall organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0961

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Guerreiro, JF et al. (2016) Sphingolipid biosynthesis upregulation by TOR complex 2-Ypk1 signaling during yeast adaptive response to acetic acid stress. Biochem. J. 473 4311-4325 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 Roelants, FM et al. (2002) Pkh1 and Pkh2 differentially phosphorylate and activate Ypk1 and Ykr2 and define protein kinase modules required for maintenance of cell wall integrity. Mol. Biol. Cell 13 3005-28 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 Roelants, FM et al. (2011) Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A. 108 19222-7 PubMed GONUTS page
  4. Yerlikaya, S et al. (2016) TORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae. Mol. Biol. Cell 27 397-409 PubMed GONUTS page
  5. Muir, A et al. (2015) Down-regulation of TORC2-Ypk1 signaling promotes MAPK-independent survival under hyperosmotic stress. Elife 4 PubMed GONUTS page
  6. Sartorel, E et al. (2015) Plasma membrane aminoglycerolipid flippase function is required for signaling competence in the yeast mating pheromone response pathway. Mol. Biol. Cell 26 134-50 PubMed GONUTS page
  7. 7.0 7.1 Surlow, BA et al. (2014) Loss of Ypk1, the yeast homolog to the human serum- and glucocorticoid-induced protein kinase, accelerates phospholipase B1-mediated phosphatidylcholine deacylation. J. Biol. Chem. 289 31591-604 PubMed GONUTS page
  8. Luo, G et al. (2008) The sphingolipid long-chain base-Pkh1/2-Ypk1/2 signaling pathway regulates eisosome assembly and turnover. J. Biol. Chem. 283 10433-44 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 9.4 Roelants, FM et al. (2010) A protein kinase network regulates the function of aminophospholipid flippases. Proc. Natl. Acad. Sci. U.S.A. 107 34-9 PubMed GONUTS page
  10. 10.0 10.1 10.2 10.3 10.4 Sun, Y et al. (2000) Sli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast. Mol. Cell. Biol. 20 4411-9 PubMed GONUTS page
  11. 11.0 11.1 11.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page