YEAST:GCN4

Species (Taxon ID)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s)	GCN4 (synonyms: AAS3, ARG9)
Protein Name(s)	General control protein GCN4 Amino acid biosynthesis regulatory protein
External Links
UniProt	P03069
EMBL	K02205 K02649 AJ585686 AJ585687 AJ585688 AJ585689 AJ585690 AJ585691 AJ585692 AJ585693 AJ585694 AJ585695 AJ585696 AJ585697 AJ585698 AJ585699 AJ585700 AJ585701 AJ585702 AJ585703 AJ585704 AF416613 U18530 BK006939
PIR	A03605
RefSeq	NP_010907.3
PDB	1CE9 1DGC 1ENV 1FAV 1FMH 1GCL 1GCM 1GK6 1GZL 1IHQ 1IJ0 1IJ1 1IJ2 1IJ3 1KQL 1LD4 1LLM 1NKN 1PIQ 1RB4 1RB5 1RB6 1SWI 1TMZ 1UNT 1UNU 1UNV 1UNW 1UNX 1UNY 1UNZ 1UO0 1UO1 1UO2 1UO3 1UO4 1UO5 1W5G 1W5H 1W5I 1W5J 1W5K 1W5L 1YSA 1ZII 1ZIJ 1ZIK 1ZIL 1ZIM 1ZTA 2AHP 2B1F 2B22 2BNI 2CCE 2CCF 2CCN 2D3E 2DGC 2EFR 2EFS 2G9J 2HY6 2IPZ 2K8X 2LPB 2NRN 2O7H 2OVN 2WG5 2WG6 2WPY 2WPZ 2WQ0 2WQ1 2WQ2 2WQ3 2YNY 2YNZ 2YO0 2YO1 2YO2 2YO3 2Z5H 2Z5I 2ZTA 3AZD 3BAS 3BAT 3CK4 3CRP 3G9R 3GJP 3I1G 3I5C 3K7Z 3M48 3P8M 3ZMF 4C46 4DMD 4G2K 4HU5 4HU6 4NIZ 4NJ0 4NJ1 4NJ2 4TL1
PDBsum	1CE9 1DGC 1ENV 1FAV 1FMH 1GCL 1GCM 1GK6 1GZL 1IHQ 1IJ0 1IJ1 1IJ2 1IJ3 1KQL 1LD4 1LLM 1NKN 1PIQ 1RB4 1RB5 1RB6 1SWI 1TMZ 1UNT 1UNU 1UNV 1UNW 1UNX 1UNY 1UNZ 1UO0 1UO1 1UO2 1UO3 1UO4 1UO5 1W5G 1W5H 1W5I 1W5J 1W5K 1W5L 1YSA 1ZII 1ZIJ 1ZIK 1ZIL 1ZIM 1ZTA 2AHP 2B1F 2B22 2BNI 2CCE 2CCF 2CCN 2D3E 2DGC 2EFR 2EFS 2G9J 2HY6 2IPZ 2K8X 2LPB 2NRN 2O7H 2OVN 2WG5 2WG6 2WPY 2WPZ 2WQ0 2WQ1 2WQ2 2WQ3 2YNY 2YNZ 2YO0 2YO1 2YO2 2YO3 2Z5H 2Z5I 2ZTA 3AZD 3BAS 3BAT 3CK4 3CRP 3G9R 3GJP 3I1G 3I5C 3K7Z 3M48 3P8M 3ZMF 4C46 4DMD 4G2K 4HU5 4HU6 4NIZ 4NJ0 4NJ1 4NJ2 4TL1
DisProt	DP00083
ProteinModelPortal	P03069
SMR	P03069
BioGrid	36723
DIP	DIP-591N
IntAct	P03069
MINT	MINT-395967
MaxQB	P03069
PaxDb	P03069
EnsemblFungi	[example_ID YEL009C]
GeneID	856709
KEGG	sce:YEL009C
CYGD	YEL009c
SGD	S000000735
eggNOG	NOG329891
InParanoid	P03069
KO	K09464
OMA	RKLQRMN
OrthoDB	EOG75QRD1
BioCyc	YEAST:G3O-30137-MONOMER
EvolutionaryTrace	P03069
NextBio	982781
Proteomes	UP000002311
Genevestigator	P03069
GO	GO:0005634 GO:0003682 GO:0042802 GO:0001191 GO:0001190 GO:0001135 GO:0043565 GO:0003700 GO:0001084 GO:0008652 GO:0010691 GO:0000122 GO:0001080 GO:0045899 GO:0060261 GO:0006366
InterPro	IPR004827
Pfam	PF00170
SMART	SM00338
PROSITE	PS50217 PS00036

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004672	protein kinase activity	PMID:21919885^[1]	ECO:0000315			F		fig.2	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:19158363^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	PMID:26649943^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:P38182)\|has_input:(UniProtKB:P11491)	Seeded From UniProt	complete
involved_in	GO:0036278	positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation	PMID:26649943^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_transcription_of:(SGD:S000003148)	Seeded From UniProt	complete
enables	GO:0043621	protein self-association	PMID:25733613^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P03069	F		Seeded From UniProt	complete
involved_in	GO:1903833	positive regulation of cellular response to amino acid starvation	PMID:6351059^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P09032	P		Seeded From UniProt	complete
involved_in	GO:1903833	positive regulation of cellular response to amino acid starvation	PMID:6351059^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter	PMID:1425591^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000003315	P		Seeded From UniProt	complete
involved_in	GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter	PMID:1425591^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	PMID:15121833^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000000189 SGD:S000000285 SGD:S000005335 SGD:S000005508 SGD:S000006175	P		Seeded From UniProt	complete
involved_in	GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	PMID:15121833^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	PMID:18794364^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:3907851^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:3464968^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:2204805^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:3530496^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:3290651^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010691	negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels	PMID:21183953^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14648200^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12455686^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:16581788^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:16581788^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:18794364^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	PMID:21183953^[14]	ECO:0000353	physical interaction evidence used in manual assertion	SGD:S000005160	F		Seeded From UniProt	complete
enables	GO:0001135	RNA polymerase II transcription regulator recruiting activity	PMID:19940160^[18]	ECO:0000353	physical interaction evidence used in manual assertion	SGD:S000005411	F		Seeded From UniProt	complete
enables	GO:0001135	RNA polymerase II transcription regulator recruiting activity	PMID:16581788^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001135	RNA polymerase II transcription regulator recruiting activity	PMID:19940160^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001135	RNA polymerase II transcription regulator recruiting activity	PMID:19940160^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	PMID:20308326^[19]	ECO:0000353	physical interaction evidence used in manual assertion	SGD:S000002552	F		Seeded From UniProt	complete
involved_in	GO:0001080	nitrogen catabolite activation of transcription from RNA polymerase II promoter	PMID:21148207^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:15590823^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:26979516^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_transcription_of:(SGD:S000000839)	Seeded From UniProt	complete
involved_in	GO:1903833	positive regulation of cellular response to amino acid starvation	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000894808 SGD:S000000735	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001291 MGI:MGI:96646 MGI:MGI:96647 MGI:MGI:96648 PANTHER:PTN000894784 RGD:2943 UniProtKB:A0A1D8PIL5 UniProtKB:P05412 UniProtKB:P17275 UniProtKB:P17535	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000894784 RGD:2943	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001291 MGI:MGI:96646 PANTHER:PTN000894784 ZFIN:ZDB-GENE-030131-7859	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000894784 UniProtKB:P05412 UniProtKB:P17275	C		Seeded From UniProt	complete
involved_in	GO:0001080	nitrogen catabolite activation of transcription from RNA polymerase II promoter	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000894808 SGD:S000000735	P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001291 PANTHER:PTN000894784	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96647 MGI:MGI:96648 PANTHER:PTN000894784	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000894784 RGD:2943	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000894784 SGD:S000000735	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25733613^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P03069	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:23348965^[24]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P03069	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:22157749^[25]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P03069	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21474779^[26]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P03069	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21045134^[27]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P03069	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:16844784^[28]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P03069	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:16472744^[29]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P03069	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:16402857^[30]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P03069	F		Seeded From UniProt	complete
involved_in	GO:0051123	RNA polymerase II preinitiation complex assembly	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0001135	P		Seeded From UniProt	complete
involved_in	GO:0051123	RNA polymerase II preinitiation complex assembly	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0001135	P		Seeded From UniProt	complete
involved_in	GO:0051123	RNA polymerase II preinitiation complex assembly	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0001135	P		Seeded From UniProt	complete
involved_in	GO:0051123	RNA polymerase II preinitiation complex assembly	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0001135	P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004827	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004827	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0008652	cellular amino acid biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0028	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Hueso, G et al. (2012) A novel role for protein kinase Gcn2 in yeast tolerance to intracellular acid stress. Biochem. J. 441 255-64 PubMed GONUTS page
↑ Zhu, C et al. (2009) High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res. 19 556-66 PubMed GONUTS page
↑ ^3.0 ^3.1 Bernard, A et al. (2015) A large-scale analysis of autophagy-related gene expression identifies new regulators of autophagy. Autophagy 11 2114-2122 PubMed GONUTS page
↑ ^4.0 ^4.1 Guidolin, LS et al. (2015) Interaction network and localization of Brucella abortus membrane proteins involved in the synthesis, transport, and succinylation of cyclic β-1,2-glucans. J. Bacteriol. 197 1640-8 PubMed GONUTS page
↑ ^5.0 ^5.1 Hinnebusch, AG & Fink, GR (1983) Positive regulation in the general amino acid control of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A. 80 5374-8 PubMed GONUTS page
↑ ^6.0 ^6.1 Mösch, HU et al. (1992) Sequence-specific initiator elements focus initiation of transcription to distinct sites in the yeast TRP4 promoter. EMBO J. 11 4583-90 PubMed GONUTS page
↑ ^7.0 ^7.1 Qiu, H et al. (2004) An array of coactivators is required for optimal recruitment of TATA binding protein and RNA polymerase II by promoter-bound Gcn4p. Mol. Cell. Biol. 24 4104-17 PubMed GONUTS page
↑ ^8.0 ^8.1 Zhang, F et al. (2008) Disrupting vesicular trafficking at the endosome attenuates transcriptional activation by Gcn4. Mol. Cell. Biol. 28 6796-818 PubMed GONUTS page
↑ Hope, IA & Struhl, K (1985) GCN4 protein, synthesized in vitro, binds HIS3 regulatory sequences: implications for general control of amino acid biosynthetic genes in yeast. Cell 43 177-88 PubMed GONUTS page
↑ Arndt, K & Fink, GR (1986) GCN4 protein, a positive transcription factor in yeast, binds general control promoters at all 5' TGACTC 3' sequences. Proc. Natl. Acad. Sci. U.S.A. 83 8516-20 PubMed GONUTS page
↑ Sellers, JW et al. (1990) Mutations that define the optimal half-site for binding yeast GCN4 activator protein and identify an ATF/CREB-like repressor that recognizes similar DNA sites. Mol. Cell. Biol. 10 5077-86 PubMed GONUTS page
↑ Hope, IA & Struhl, K (1986) Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast. Cell 46 885-94 PubMed GONUTS page
↑ Roussou, I et al. (1988) Transcriptional-translational regulatory circuit in Saccharomyces cerevisiae which involves the GCN4 transcriptional activator and the GCN2 protein kinase. Mol. Cell. Biol. 8 2132-9 PubMed GONUTS page
↑ ^14.0 ^14.1 Joo, YJ et al. (2011) Gcn4p-mediated transcriptional repression of ribosomal protein genes under amino-acid starvation. EMBO J. 30 859-72 PubMed GONUTS page
↑ Pries, R et al. (2004) Nuclear import of yeast Gcn4p requires karyopherins Srp1p and Kap95p. Mol. Genet. Genomics 271 257-66 PubMed GONUTS page
↑ Pries, R et al. (2002) Amino acid-dependent Gcn4p stability regulation occurs exclusively in the yeast nucleus. Eukaryotic Cell 1 663-72 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Qiu, H et al. (2006) The Spt4p subunit of yeast DSIF stimulates association of the Paf1 complex with elongating RNA polymerase II. Mol. Cell. Biol. 26 3135-48 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Jedidi, I et al. (2010) Activator Gcn4 employs multiple segments of Med15/Gal11, including the KIX domain, to recruit mediator to target genes in vivo. J. Biol. Chem. 285 2438-55 PubMed GONUTS page
↑ Herbig, E et al. (2010) Mechanism of Mediator recruitment by tandem Gcn4 activation domains and three Gal11 activator-binding domains. Mol. Cell. Biol. 30 2376-90 PubMed GONUTS page
↑ Teixeira, MC et al. (2011) Yeast response and tolerance to polyamine toxicity involving the drug : H+ antiporter Qdr3 and the transcription factors Yap1 and Gcn4. Microbiology (Reading, Engl.) 157 945-56 PubMed GONUTS page
↑ Velasco, I et al. (2004) Saccharomyces cerevisiae Aqr1 is an internal-membrane transporter involved in excretion of amino acids. Eukaryotic Cell 3 1492-503 PubMed GONUTS page
↑ Yadav, KK & Rajasekharan, R (2016) The transcription factor GCN4 regulates PHM8 and alters triacylglycerol metabolism in Saccharomyces cerevisiae. Curr. Genet. 62 841-851 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 ^23.6 ^23.7 ^23.8 ^23.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Erce, MA et al. (2013) A conditional two-hybrid (C2H) system for the detection of protein-protein interactions that are mediated by post-translational modification. Proteomics 13 1059-64 PubMed GONUTS page
↑ Cisneros, DA et al. (2012) Minor pseudopilin self-assembly primes type II secretion pseudopilus elongation. EMBO J. 31 1041-53 PubMed GONUTS page
↑ Miot, M et al. (2011) Species-specific collaboration of heat shock proteins (Hsp) 70 and 100 in thermotolerance and protein disaggregation. Proc. Natl. Acad. Sci. U.S.A. 108 6915-20 PubMed GONUTS page
↑ Ciani, B et al. (2010) Molecular basis of coiled-coil oligomerization-state specificity. Proc. Natl. Acad. Sci. U.S.A. 107 19850-5 PubMed GONUTS page
↑ Singh, A et al. (2006) Dissecting virulence pathways of Mycobacterium tuberculosis through protein-protein association. Proc. Natl. Acad. Sci. U.S.A. 103 11346-51 PubMed GONUTS page
↑ Deng, Y et al. (2006) Antiparallel four-stranded coiled coil specified by a 3-3-1 hydrophobic heptad repeat. Structure 14 247-55 PubMed GONUTS page
↑ Benton, R et al. (2006) Atypical membrane topology and heteromeric function of Drosophila odorant receptors in vivo. PLoS Biol. 4 e20 PubMed GONUTS page

[PMID:21919885-1] Hueso, G et al. (2012) A novel role for protein kinase Gcn2 in yeast tolerance to intracellular acid stress. Biochem. J. 441 255-64 PubMed GONUTS page

[PMID:19158363-2] Zhu, C et al. (2009) High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res. 19 556-66 PubMed GONUTS page

[PMID:26649943-3] 3.0 ^3.1 Bernard, A et al. (2015) A large-scale analysis of autophagy-related gene expression identifies new regulators of autophagy. Autophagy 11 2114-2122 PubMed GONUTS page

[PMID:25733613-4] 4.0 ^4.1 Guidolin, LS et al. (2015) Interaction network and localization of Brucella abortus membrane proteins involved in the synthesis, transport, and succinylation of cyclic β-1,2-glucans. J. Bacteriol. 197 1640-8 PubMed GONUTS page

[PMID:6351059-5] 5.0 ^5.1 Hinnebusch, AG & Fink, GR (1983) Positive regulation in the general amino acid control of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A. 80 5374-8 PubMed GONUTS page

[PMID:1425591-6] 6.0 ^6.1 Mösch, HU et al. (1992) Sequence-specific initiator elements focus initiation of transcription to distinct sites in the yeast TRP4 promoter. EMBO J. 11 4583-90 PubMed GONUTS page

[PMID:15121833-7] 7.0 ^7.1 Qiu, H et al. (2004) An array of coactivators is required for optimal recruitment of TATA binding protein and RNA polymerase II by promoter-bound Gcn4p. Mol. Cell. Biol. 24 4104-17 PubMed GONUTS page

[PMID:18794364-8] 8.0 ^8.1 Zhang, F et al. (2008) Disrupting vesicular trafficking at the endosome attenuates transcriptional activation by Gcn4. Mol. Cell. Biol. 28 6796-818 PubMed GONUTS page

[PMID:3907851-9] Hope, IA & Struhl, K (1985) GCN4 protein, synthesized in vitro, binds HIS3 regulatory sequences: implications for general control of amino acid biosynthetic genes in yeast. Cell 43 177-88 PubMed GONUTS page

[PMID:3464968-10] Arndt, K & Fink, GR (1986) GCN4 protein, a positive transcription factor in yeast, binds general control promoters at all 5' TGACTC 3' sequences. Proc. Natl. Acad. Sci. U.S.A. 83 8516-20 PubMed GONUTS page

[PMID:2204805-11] Sellers, JW et al. (1990) Mutations that define the optimal half-site for binding yeast GCN4 activator protein and identify an ATF/CREB-like repressor that recognizes similar DNA sites. Mol. Cell. Biol. 10 5077-86 PubMed GONUTS page

[PMID:3530496-12] Hope, IA & Struhl, K (1986) Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast. Cell 46 885-94 PubMed GONUTS page

[PMID:3290651-13] Roussou, I et al. (1988) Transcriptional-translational regulatory circuit in Saccharomyces cerevisiae which involves the GCN4 transcriptional activator and the GCN2 protein kinase. Mol. Cell. Biol. 8 2132-9 PubMed GONUTS page

[PMID:21183953-14] 14.0 ^14.1 Joo, YJ et al. (2011) Gcn4p-mediated transcriptional repression of ribosomal protein genes under amino-acid starvation. EMBO J. 30 859-72 PubMed GONUTS page

[PMID:14648200-15] Pries, R et al. (2004) Nuclear import of yeast Gcn4p requires karyopherins Srp1p and Kap95p. Mol. Genet. Genomics 271 257-66 PubMed GONUTS page

[PMID:12455686-16] Pries, R et al. (2002) Amino acid-dependent Gcn4p stability regulation occurs exclusively in the yeast nucleus. Eukaryotic Cell 1 663-72 PubMed GONUTS page

[PMID:16581788-17] 17.0 ^17.1 ^17.2 Qiu, H et al. (2006) The Spt4p subunit of yeast DSIF stimulates association of the Paf1 complex with elongating RNA polymerase II. Mol. Cell. Biol. 26 3135-48 PubMed GONUTS page

[PMID:19940160-18] 18.0 ^18.1 ^18.2 Jedidi, I et al. (2010) Activator Gcn4 employs multiple segments of Med15/Gal11, including the KIX domain, to recruit mediator to target genes in vivo. J. Biol. Chem. 285 2438-55 PubMed GONUTS page

[PMID:20308326-19] Herbig, E et al. (2010) Mechanism of Mediator recruitment by tandem Gcn4 activation domains and three Gal11 activator-binding domains. Mol. Cell. Biol. 30 2376-90 PubMed GONUTS page

[PMID:21148207-20] Teixeira, MC et al. (2011) Yeast response and tolerance to polyamine toxicity involving the drug : H+ antiporter Qdr3 and the transcription factors Yap1 and Gcn4. Microbiology (Reading, Engl.) 157 945-56 PubMed GONUTS page

[PMID:15590823-21] Velasco, I et al. (2004) Saccharomyces cerevisiae Aqr1 is an internal-membrane transporter involved in excretion of amino acids. Eukaryotic Cell 3 1492-503 PubMed GONUTS page

[PMID:26979516-22] Yadav, KK & Rajasekharan, R (2016) The transcription factor GCN4 regulates PHM8 and alters triacylglycerol metabolism in Saccharomyces cerevisiae. Curr. Genet. 62 841-851 PubMed GONUTS page

[PMID:21873635-23] 23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 ^23.6 ^23.7 ^23.8 ^23.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23348965-24] Erce, MA et al. (2013) A conditional two-hybrid (C2H) system for the detection of protein-protein interactions that are mediated by post-translational modification. Proteomics 13 1059-64 PubMed GONUTS page

[PMID:22157749-25] Cisneros, DA et al. (2012) Minor pseudopilin self-assembly primes type II secretion pseudopilus elongation. EMBO J. 31 1041-53 PubMed GONUTS page

[PMID:21474779-26] Miot, M et al. (2011) Species-specific collaboration of heat shock proteins (Hsp) 70 and 100 in thermotolerance and protein disaggregation. Proc. Natl. Acad. Sci. U.S.A. 108 6915-20 PubMed GONUTS page

[PMID:21045134-27] Ciani, B et al. (2010) Molecular basis of coiled-coil oligomerization-state specificity. Proc. Natl. Acad. Sci. U.S.A. 107 19850-5 PubMed GONUTS page

[PMID:16844784-28] Singh, A et al. (2006) Dissecting virulence pathways of Mycobacterium tuberculosis through protein-protein association. Proc. Natl. Acad. Sci. U.S.A. 103 11346-51 PubMed GONUTS page

[PMID:16472744-29] Deng, Y et al. (2006) Antiparallel four-stranded coiled coil specified by a 3-3-1 hydrophobic heptad repeat. Structure 14 247-55 PubMed GONUTS page

[PMID:16402857-30] Benton, R et al. (2006) Atypical membrane topology and heteromeric function of Drosophila odorant receptors in vivo. PLoS Biol. 4 e20 PubMed GONUTS page

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