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XENLA:WN11B

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Species (Taxon ID) Xenopus laevis (African clawed frog). (8355)
Gene Name(s) wnt11b (synonyms: wnt-11, wnt11)
Protein Name(s) Protein Wnt-11b

Protein Wnt-11 XWnt-11

External Links
UniProt P49893
EMBL L23542
BC084745
PIR I51572
RefSeq NP_001084327.1
UniGene Xl.24008
ProteinModelPortal P49893
IntAct P49893
GeneID 399441
KEGG xla:399441
CTD 399441
Xenbase XB-GENE-6079153
HOVERGEN HBG001595
KO K01384
GO GO:0005737
GO:0005576
GO:0005615
GO:0005886
GO:0043234
GO:0005578
GO:0005109
GO:0019838
GO:0042803
GO:0030295
GO:0005099
GO:0044212
GO:0017147
GO:0060070
GO:0042074
GO:0060027
GO:0009950
GO:0006897
GO:0007507
GO:0060914
GO:0043066
GO:0090090
GO:0060548
GO:0030308
GO:0030336
GO:0045892
GO:0001755
GO:0061101
GO:0035567
GO:0060021
GO:0030335
GO:0010628
GO:0046330
GO:0045860
GO:0090037
GO:0032320
GO:0051496
GO:0045893
GO:0048793
GO:0034394
GO:0006468
GO:0016055
GO:0060071
InterPro IPR005817
IPR018161
PANTHER PTHR12027
Pfam PF00110
PRINTS PR01349
SMART SM00097
PROSITE PS00246

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0035567

non-canonical Wnt signaling pathway

PMID:19906850[1]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

colocalizes_with

GO:0005615

extracellular space

PMID:19906850[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:19906850[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0090090

negative regulation of canonical Wnt signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O96014

P

Seeded From UniProt

complete

involved_in

GO:0090037

positive regulation of protein kinase C signaling

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O96014

P

Seeded From UniProt

complete

involved_in

GO:0061101

neuroendocrine cell differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O96014

P

Seeded From UniProt

complete

involved_in

GO:0060914

heart formation

PMID:12167861[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060548

negative regulation of cell death

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O96014

P

Seeded From UniProt

complete

involved_in

GO:0060071

Wnt signaling pathway, planar cell polarity pathway

PMID:17663724[3]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P51142

P

Seeded From UniProt

complete

involved_in

GO:0060070

canonical Wnt signaling pathway

PMID:19747829[4]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P31286

P

Seeded From UniProt

complete

involved_in

GO:0060070

canonical Wnt signaling pathway

PMID:18927149[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060027

convergent extension involved in gastrulation

PMID:10769246[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0062009

secondary palate development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O96014

P

Seeded From UniProt

complete

involved_in

GO:0051496

positive regulation of stress fiber assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O96014

P

Seeded From UniProt

complete

involved_in

GO:0048793

pronephros development

PMID:19582868[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046330

positive regulation of JNK cascade

PMID:12167861[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O96014

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O96014

P

Seeded From UniProt

complete

enables

GO:0044212

transcription regulatory region DNA binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O96014

F

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

PMID:19747829[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P31286

C

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

PMID:18927149[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P31286

C

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O96014

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:18927149[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0042074

cell migration involved in gastrulation

PMID:10862746[8]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9PUK8

P

Seeded From UniProt

complete

involved_in

GO:0042074

cell migration involved in gastrulation

PMID:18809723[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042074

cell migration involved in gastrulation

PMID:11128985[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042074

cell migration involved in gastrulation

PMID:7739543[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042074

cell migration involved in gastrulation

PMID:10751186[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035567

non-canonical Wnt signaling pathway

PMID:15857909[13]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P51142

P

Seeded From UniProt

complete

involved_in

GO:0035567

non-canonical Wnt signaling pathway

PMID:10769246[6]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P51142

P

Seeded From UniProt

complete

involved_in

GO:0035567

non-canonical Wnt signaling pathway

PMID:11128985[10]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P51142

P

Seeded From UniProt

complete

involved_in

GO:0035567

non-canonical Wnt signaling pathway

PMID:18927149[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034394

protein localization to cell surface

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O96014

P

Seeded From UniProt

complete

involved_in

GO:0043547

positive regulation of GTPase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O96014

P

Seeded From UniProt

complete

involved_in

GO:0030336

negative regulation of cell migration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O96014

P

Seeded From UniProt

complete

involved_in

GO:0030335

positive regulation of cell migration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O96014

P

Seeded From UniProt

complete

involved_in

GO:0030308

negative regulation of cell growth

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O96014

P

Seeded From UniProt

complete

enables

GO:0030295

protein kinase activator activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O96014

F

Seeded From UniProt

complete

enables

GO:0019838

growth factor binding

PMID:15797385[14]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q91649

F

Seeded From UniProt

complete

enables

GO:0019838

growth factor binding

PMID:15797385[14]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P51865

F

Seeded From UniProt

complete

enables

GO:0017147

Wnt-protein binding

PMID:19747829[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P31286

F

Seeded From UniProt

complete

enables

GO:0017147

Wnt-protein binding

PMID:18927149[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P31286

F

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

PMID:17663724[3]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q9PUK8

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

PMID:10751186[12]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q9PUK8

P

Seeded From UniProt

complete

NOT|involved_in

GO:0014036

neural crest cell fate specification

PMID:15857909[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O96014

P

Seeded From UniProt

complete

involved_in

GO:0009950

dorsal/ventral axis specification

PMID:17202189[15]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q9DFH4

P

Seeded From UniProt

complete

involved_in

GO:0009950

dorsal/ventral axis specification

PMID:10751186[12]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q9PUK8

P

Seeded From UniProt

complete

involved_in

GO:0009950

dorsal/ventral axis specification

PMID:15797385[14]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q9PUK8

P

Seeded From UniProt

complete

involved_in

GO:0009950

dorsal/ventral axis specification

PMID:18927149[5]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P31286

P

Seeded From UniProt

complete

involved_in

GO:0009950

dorsal/ventral axis specification

PMID:15797385[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009950

dorsal/ventral axis specification

PMID:8306880[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007507

heart development

PMID:18715946[17]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006897

endocytosis

PMID:18809723[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O96014

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:10862746[8]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9PUK8

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O96014

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:19747829[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:18927149[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q670P5

C

Seeded From UniProt

complete

enables

GO:0005109

frizzled binding

PMID:10862746[8]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9PUK8

F

Seeded From UniProt

complete

enables

GO:0005109

frizzled binding

PMID:16274967[18]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9PUK8

F

Seeded From UniProt

complete

enables

GO:0005096

GTPase activator activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O96014

F

Seeded From UniProt

complete

NOT|involved_in

GO:0003129

heart induction

PMID:11159911[19]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001755

neural crest cell migration

PMID:15857909[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032147

activation of protein kinase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0030295

P

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005817

P

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

involved_in

GO:0007369

gastrulation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0306

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0879

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Mii, Y & Taira, M (2009) Secreted Frizzled-related proteins enhance the diffusion of Wnt ligands and expand their signalling range. Development 136 4083-8 PubMed GONUTS page
  2. 2.0 2.1 Pandur, P et al. (2002) Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis. Nature 418 636-41 PubMed GONUTS page
  3. 3.0 3.1 Yamanaka, H & Nishida, E (2007) Wnt11 stimulation induces polarized accumulation of Dishevelled at apical adherens junctions through Frizzled7. Genes Cells 12 961-7 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Cha, SW et al. (2009) Wnt11/5a complex formation caused by tyrosine sulfation increases canonical signaling activity. Curr. Biol. 19 1573-80 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 5.5 5.6 Cha, SW et al. (2008) Wnt5a and Wnt11 interact in a maternal Dkk1-regulated fashion to activate both canonical and non-canonical signaling in Xenopus axis formation. Development 135 3719-29 PubMed GONUTS page
  6. 6.0 6.1 Tada, M & Smith, JC (2000) Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway. Development 127 2227-38 PubMed GONUTS page
  7. Tételin, S & Jones, EA (2010) Xenopus Wnt11b is identified as a potential pronephric inducer. Dev. Dyn. 239 148-59 PubMed GONUTS page
  8. 8.0 8.1 8.2 Djiane, A et al. (2000) Role of frizzled 7 in the regulation of convergent extension movements during gastrulation in Xenopus laevis. Development 127 3091-100 PubMed GONUTS page
  9. 9.0 9.1 Kim, GH et al. (2008) Ryk cooperates with Frizzled 7 to promote Wnt11-mediated endocytosis and is essential for Xenopus laevis convergent extension movements. J. Cell Biol. 182 1073-82 PubMed GONUTS page
  10. 10.0 10.1 Smith, JC et al. (2000) Xwnt11 and the regulation of gastrulation in Xenopus. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 923-30 PubMed GONUTS page
  11. Du, SJ et al. (1995) Identification of distinct classes and functional domains of Wnts through expression of wild-type and chimeric proteins in Xenopus embryos. Mol. Cell. Biol. 15 2625-34 PubMed GONUTS page
  12. 12.0 12.1 12.2 Sumanas, S et al. (2000) The putative wnt receptor Xenopus frizzled-7 functions upstream of beta-catenin in vertebrate dorsoventral mesoderm patterning. Development 127 1981-90 PubMed GONUTS page
  13. 13.0 13.1 13.2 De Calisto, J et al. (2005) Essential role of non-canonical Wnt signalling in neural crest migration. Development 132 2587-97 PubMed GONUTS page
  14. 14.0 14.1 14.2 14.3 Tao, Q et al. (2005) Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos. Cell 120 857-71 PubMed GONUTS page
  15. Kofron, M et al. (2007) Wnt11/beta-catenin signaling in both oocytes and early embryos acts through LRP6-mediated regulation of axin. Development 134 503-13 PubMed GONUTS page
  16. Ku, M & Melton, DA (1993) Xwnt-11: a maternally expressed Xenopus wnt gene. Development 119 1161-73 PubMed GONUTS page
  17. Afouda, BA et al. (2008) GATA transcription factors integrate Wnt signalling during heart development. Development 135 3185-90 PubMed GONUTS page
  18. Shibata, M et al. (2005) Role of crescent in convergent extension movements by modulating Wnt signaling in early Xenopus embryogenesis. Mech. Dev. 122 1322-39 PubMed GONUTS page
  19. Schneider, VA & Mercola, M (2001) Wnt antagonism initiates cardiogenesis in Xenopus laevis. Genes Dev. 15 304-15 PubMed GONUTS page