XENLA:APC

Species (Taxon ID)	Xenopus laevis (African clawed frog). (8355)
Gene Name(s)	apc
Protein Name(s)	Adenomatous polyposis coli homolog Protein APC
External Links
UniProt	P70039
EMBL	U64442
RefSeq	NP_001084351.1
UniGene	Xl.8436
ProteinModelPortal	P70039
SMR	P70039
BioGrid	100780
IntAct	P70039
MINT	MINT-7305229
PRIDE	P70039
GeneID	399455
KEGG	xla:399455
CTD	324
Xenbase	XB-GENE-480859
HOVERGEN	HBG004264
KO	K02085
PRO	PR:P70039
GO	GO:0030877 GO:0005813 GO:0005737 GO:0000776 GO:0005634 GO:0008013 GO:0008017 GO:0019887 GO:0007050 GO:0016477 GO:0006974 GO:0000281 GO:0008285 GO:0045736 GO:0007026 GO:0030178 GO:0043065 GO:0006461 GO:0016055
Gene3D	1.25.10.10
InterPro	IPR026836 IPR009240 IPR009234 IPR009223 IPR026831 IPR026818 IPR011989 IPR016024 IPR000225 IPR009232 IPR009224
PANTHER	PTHR12607 PTHR12607:SF11
Pfam	PF05972 PF05956 PF05923 PF00514 PF05937 PF05924 PF11414
SMART	SM00185
SUPFAM	SSF48371

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
Contributes to	GO:0010032	meiotic chromosome condensation	PMID:22719865	ECO:0000314			P		APC depletion almost doubled the fraction of rod-like and compacted chromatin in comparison to control or mock-depleted in meiosis of Xenopus sperm cells.	complete
involved_in	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	C		Seeded From UniProt	complete
enables	GO:0019887	protein kinase regulator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	F		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	F		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
involved_in	GO:0007026	negative regulation of microtubule depolymerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
involved_in	GO:0065003	protein-containing complex assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	P		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	C		Seeded From UniProt	complete
part_of	GO:0000776	kinetochore	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P25054	C		Seeded From UniProt	complete
involved_in	GO:0000281	mitotic cytokinesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026836	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026836	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026836	C		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026836	P		Seeded From UniProt	complete
involved_in	GO:0007026	negative regulation of microtubule depolymerization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026836	P		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026836	P		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009224 InterPro:IPR009232 InterPro:IPR009240 InterPro:IPR026818 InterPro:IPR026836	F		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009234	F		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026836	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009223 InterPro:IPR009224 InterPro:IPR009232 InterPro:IPR009234 InterPro:IPR009240	P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026836	P		Seeded From UniProt	complete
involved_in	GO:0030178	negative regulation of Wnt signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026818 InterPro:IPR026836	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026836	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
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References

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