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WB:akt-1

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Species (Taxon ID) Caenorhabditis elegans (nematode) (taxon:6239)
Gene Name(s) akt-1 ( synonyms: C12D8.10, akt-1b )
Protein Name(s) No Information Provided.
External Links
WB WBGene00000102

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004672

protein kinase activity

PMID:12520011[1]
PMID:12654719[2]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR000719

F

From WB

GO:0004672

protein kinase activity

PMID:12520011[1]
PMID:12654719[2]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR001245

F

From WB

GO:0004672

protein kinase activity

PMID:12520011[1]
PMID:12654719[2]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR002290

F

From WB

GO:0004674

protein serine/threonine kinase activity

PMID:12520011[1]
PMID:12654719[2]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR000961

F

From WB

GO:0004674

protein serine/threonine kinase activity

PMID:12520011[1]
PMID:12654719[2]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR008271

F

From WB

GO:0004674

protein serine/threonine kinase activity

PMID:12520011[1]
PMID:12654719[2]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR017892

F

From WB

GO:0004674

protein serine/threonine kinase activity

WB_REF:WBPaper00003173
PMID:9716402[3]

ISS: Inferred from Sequence or Structural Similarity

F

From WB

GO:0004674

protein serine/threonine kinase activity

WB_REF:WBPaper00031617
PMID:18358814[4]

IDA: Inferred from Direct Assay

F

From WB

GO:0004713

protein tyrosine kinase activity

PMID:12520011[1]
PMID:12654719[2]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR020635

F

From WB

GO:0005516

calmodulin binding

WB_REF:WBPaper00030800
PMID:17580302[5]

IDA: Inferred from Direct Assay

F

From WB

GO:0005516

calmodulin binding

WB_REF:WBPaper00031011
PMID:17854888[6]

IPI: Inferred from Physical Interaction

UniProtKB:P62157

F

From WB

GO:0005524

ATP binding

PMID:12520011[1]
PMID:12654719[2]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR000719

F

From WB

GO:0005524

ATP binding

PMID:12520011[1]
PMID:12654719[2]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR000961

F

From WB

GO:0005524

ATP binding

PMID:12520011[1]
PMID:12654719[2]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR002290

F

From WB

GO:0005524

ATP binding

PMID:12520011[1]
PMID:12654719[2]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR017441

F

From WB

GO:0005524

ATP binding

PMID:12520011[1]
PMID:12654719[2]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR017892

F

From WB

GO:0005543

phospholipid binding

PMID:12520011[1]
PMID:12654719[2]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR001849

F

From WB

GO:0005622

intracellular

WB_REF:WBPaper00003173
PMID:9716402[3]

IDA: Inferred from Direct Assay

C

From WB

GO:0006468

protein phosphorylation

PMID:12520011[1]
PMID:12654719[2]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR000719

P

From WB

GO:0006468

protein phosphorylation

PMID:12520011[1]
PMID:12654719[2]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR000961

P

From WB

GO:0006468

protein phosphorylation

PMID:12520011[1]
PMID:12654719[2]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR001245

P

From WB

GO:0006468

protein phosphorylation

PMID:12520011[1]
PMID:12654719[2]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR002290

P

From WB

GO:0006468

protein phosphorylation

PMID:12520011[1]
PMID:12654719[2]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR008271

P

From WB

GO:0006468

protein phosphorylation

PMID:12520011[1]
PMID:12654719[2]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR017892

P

From WB

GO:0006468

protein phosphorylation

PMID:12520011[1]
PMID:12654719[2]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR020635

P

From WB

GO:0006468

protein phosphorylation

WB_REF:WBPaper00003173
PMID:9716402[3]

ISS: Inferred from Sequence or Structural Similarity

P

From WB

GO:0008286

insulin receptor signaling pathway

WB_REF:WBPaper00003173
PMID:9716402[3]

IMP: Inferred from Mutant Phenotype

P

From WB

GO:0008340

determination of adult lifespan

WB_REF:WBPaper00003872
PMID:10638522[7]

IMP: Inferred from Mutant Phenotype

P

From WB

GO:0008340

determination of adult lifespan

WB_REF:WBPaper00013413
PMID:15068796[8]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00038561
WB:WBPhenotype:0000039

P

From WB

GO:0008340

determination of adult lifespan

WB_REF:WBPaper00013413
PMID:15068796[8]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00038564
WB:WBPhenotype:0000039

P

From WB

GO:0008340

determination of adult lifespan

WB_REF:WBPaper00026643
PMID:15998808[9]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00065303
WB:WBPhenotype:0000061

P

From WB

GO:0008340

determination of adult lifespan

WB_REF:WBPaper00031617
PMID:18358814[4]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00087412
WB:WBPhenotype:0000061

P

From WB

GO:0008340

determination of adult lifespan

WB_REF:WBPaper00031617
PMID:18358814[4]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00087414
WB:WBPhenotype:0000061

P

From WB

GO:0008340

determination of adult lifespan

WB_REF:WBPaper00031617
PMID:18358814[4]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00087415
WB:WBPhenotype:0000061

P

From WB

GO:0043053

dauer entry

WB_REF:WBPaper00013413
PMID:15068796[8]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00038561
WB:WBPhenotype:0000637

P

From WB

GO:0043053

dauer entry

WB_REF:WBPaper00013413
PMID:15068796[8]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00038563
WB:WBPhenotype:0000637

P

From WB

GO:0043053

dauer entry

WB_REF:WBPaper00013413
PMID:15068796[8]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00038564
WB:WBPhenotype:0000637

P

From WB

GO:0043053

dauer entry

WB_REF:WBPaper00013413
PMID:15068796[8]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00038566
WB:WBPhenotype:0000637

P

From WB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 1.18 1.19 Mulder, NJ et al. (2003) The InterPro Database, 2003 brings increased coverage and new features. Nucleic Acids Res. 31 315-8 PubMed GONUTS page
  2. 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 2.14 2.15 2.16 2.17 2.18 2.19 Camon, E et al. (2003) The Gene Ontology Annotation (GOA) project: implementation of GO in SWISS-PROT, TrEMBL, and InterPro. Genome Res. 13 662-72 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Paradis, S & Ruvkun, G (1998) Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev. 12 2488-98 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 Tullet, JM et al. (2008) Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell 132 1025-38 PubMed GONUTS page
  5. Dong, B et al. (2007) Ca(2+)/calmodulin directly interacts with the pleckstrin homology domain of AKT1. J. Biol. Chem. 282 25131-40 PubMed GONUTS page
  6. Shen, X et al. (2008) Ca(2+)/Calmodulin-binding proteins from the C. elegans proteome. Cell Calcium 43 444-56 PubMed GONUTS page
  7. Vanfleteren, JR & Braeckman, BP () Mechanisms of life span determination in Caenorhabditis elegans. Neurobiol. Aging 20 487-502 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 8.4 8.5 Hertweck, M et al. (2004) C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span. Dev. Cell 6 577-88 PubMed GONUTS page
  9. Hamilton, B et al. (2005) A systematic RNAi screen for longevity genes in C. elegans. Genes Dev. 19 1544-55 PubMed GONUTS page
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