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WB:air-2

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Species (Taxon ID) Caenorhabditis elegans (nematode) (taxon:6239)
Gene Name(s) air-2 ( synonyms: cyk-6, B0207.4 )
Protein Name(s) No Information Provided.
External Links
WB WBGene00000099

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000793

condensed chromosome

WB_REF:WBPaper00004303
PMID:10983970[1]

IDA: Inferred from Direct Assay

C

From WB

GO:0000794

condensed nuclear chromosome

WB_REF:WBPaper00004303
PMID:10983970[1]

IDA: Inferred from Direct Assay

C

From WB

GO:0000794

condensed nuclear chromosome

WB_REF:WBPaper00004544
PMID:11050384[2]

IDA: Inferred from Direct Assay

C

From WB

GO:0004672

protein kinase activity

PMID:12520011[3]
PMID:12654719[4]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR000719

F

From WB

GO:0004672

protein kinase activity

PMID:12520011[3]
PMID:12654719[4]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR001245

F

From WB

GO:0004672

protein kinase activity

PMID:12520011[3]
PMID:12654719[4]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR002290

F

From WB

GO:0004672

protein kinase activity

WB_REF:WBPaper00032264
PMID:18854144[5]

IDA: Inferred from Direct Assay

F

From WB

GO:0004674

protein serine/threonine kinase activity

PMID:12520011[3]
PMID:12654719[4]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR008271

F

From WB

GO:0004674

protein serine/threonine kinase activity

WB_REF:WBPaper00004303
PMID:10983970[1]

NAS: Non-traceable Author Statement

F

From WB

GO:0004674

protein serine/threonine kinase activity

WB_REF:WBPaper00005311
PMID:11940606[6]

IDA: Inferred from Direct Assay

F

From WB

GO:0004674

protein serine/threonine kinase activity

WB_REF:WBPaper00005390
PMID:12048181[7]

IDA: Inferred from Direct Assay

F

From WB

GO:0004674

protein serine/threonine kinase activity

WB_REF:WBPaper00024605
PMID:15548597[8]

IDA: Inferred from Direct Assay

F

From WB

GO:0004674

protein serine/threonine kinase activity

WB_REF:WBPaper00026599
PMID:15916946[9]

IDA: Inferred from Direct Assay

F

From WB

GO:0004713

protein tyrosine kinase activity

PMID:12520011[3]
PMID:12654719[4]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR020635

F

From WB

GO:0005524

ATP binding

PMID:12520011[3]
PMID:12654719[4]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR000719

F

From WB

GO:0005524

ATP binding

PMID:12520011[3]
PMID:12654719[4]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR002290

F

From WB

GO:0005524

ATP binding

PMID:12520011[3]
PMID:12654719[4]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR017441

F

From WB

GO:0005819

spindle

WB_REF:WBPaper00004303
PMID:10983970[1]

IDA: Inferred from Direct Assay

C

From WB

GO:0006468

protein phosphorylation

PMID:12520011[3]
PMID:12654719[4]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR000719

P

From WB

GO:0006468

protein phosphorylation

PMID:12520011[3]
PMID:12654719[4]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR001245

P

From WB

GO:0006468

protein phosphorylation

PMID:12520011[3]
PMID:12654719[4]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR002290

P

From WB

GO:0006468

protein phosphorylation

PMID:12520011[3]
PMID:12654719[4]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR008271

P

From WB

GO:0006468

protein phosphorylation

PMID:12520011[3]
PMID:12654719[4]

IEA: Inferred from Electronic Annotation

INTERPRO:IPR020635

P

From WB

GO:0006468

protein phosphorylation

WB_REF:WBPaper00032264
PMID:18854144[5]

IDA: Inferred from Direct Assay

P

From WB

GO:0007052

mitotic spindle organization

WB_REF:WBPaper00004303
PMID:10983970[1]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00069121
WB:WBPhenotype:0001102

P

From WB

GO:0007059

chromosome segregation

WB_REF:WBPaper00004303
PMID:10983970[1]

IMP: Inferred from Mutant Phenotype

P

From WB

GO:0007059

chromosome segregation

WB_REF:WBPaper00004544
PMID:11050384[2]

IMP: Inferred from Mutant Phenotype

WB:WBVar00094701

P

From WB

GO:0007067

mitosis

WB_REF:WBPaper00024200
PMID:15166316[10]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00080506
WB:WBPhenotype:0001743

P

From WB

GO:0007109

cytokinesis, completion of separation

WB_REF:WBPaper00004303
PMID:10983970[1]

IMP: Inferred from Mutant Phenotype

P

From WB

GO:0007126

meiosis

WB_REF:WBPaper00004303
PMID:10983970[1]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00069120
WB:WBPhenotype:0000775

P

From WB

GO:0007126

meiosis

WB_REF:WBPaper00005264
PMID:12015116[11]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00022920
WB:WBPhenotype:0001041

P

From WB

GO:0007126

meiosis

WB_REF:WBPaper00005311
PMID:11940606[6]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00022765
WB:WBPhenotype:0001041

P

From WB

GO:0007126

meiosis

WB_REF:WBPaper00024200
PMID:15166316[10]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00080506
WB:WBPhenotype:0000775

P

From WB

GO:0009792

embryo development ending in birth or egg hatching

WB_REF:WBPaper00004544
PMID:11050384[2]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00004980
WB:WBPhenotype:0000050

P

From WB

GO:0009792

embryo development ending in birth or egg hatching

WB_REF:WBPaper00005264
PMID:12015116[11]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00022918
WB:WBPhenotype:0000050

P

From WB

GO:0009792

embryo development ending in birth or egg hatching

WB_REF:WBPaper00005264
PMID:12015116[11]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00022919
WB:WBPhenotype:0000050

P

From WB

GO:0009792

embryo development ending in birth or egg hatching

WB_REF:WBPaper00024200
PMID:15166316[10]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00080506
WB:WBPhenotype:0000050

P

From WB

GO:0009792

embryo development ending in birth or egg hatching

WB_REF:WBPaper00024497
PMID:15489339[12]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00027839
WB:WBPhenotype:0000050

P

From WB

GO:0009792

embryo development ending in birth or egg hatching

WB_REF:WBPaper00024925
PMID:15687288[13]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00061497
WB:WBPhenotype:0000050

P

From WB

GO:0009792

embryo development ending in birth or egg hatching

WB_REF:WBPaper00025054
PMID:15791247[14]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00038718
WB:WBPhenotype:0000050

P

From WB

GO:0018105

peptidyl-serine phosphorylation

WB_REF:WBPaper00026599
PMID:15916946[9]

IDA: Inferred from Direct Assay

P

From WB

GO:0018107

peptidyl-threonine phosphorylation

WB_REF:WBPaper00005311
PMID:11940606[6]

IDA: Inferred from Direct Assay

P

From WB

GO:0019894

kinesin binding

WB_REF:WBPaper00004544
PMID:11050384[2]

IPI: Inferred from Physical Interaction

WB:WBGene00006974

F

From WB

GO:0030261

chromosome condensation

WB_REF:WBPaper00004303
PMID:10983970[1]

IMP: Inferred from Mutant Phenotype

P

From WB

GO:0031991

regulation of actomyosin contractile ring contraction

WB_REF:WBPaper00004544
PMID:11050384[2]

IGI: Inferred from Genetic Interaction

WB:WBGene00000872

P

From WB

GO:0031991

regulation of actomyosin contractile ring contraction

WB_REF:WBPaper00004544
PMID:11050384[2]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00004980
WB:WBVar00094701

P

From WB

GO:0040011

locomotion

WB_REF:WBPaper00024200
PMID:15166316[10]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00080506
WB:WBPhenotype:0000643

P

From WB

GO:0040035

hermaphrodite genitalia development

WB_REF:WBPaper00024497
PMID:15489339[12]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00027839
WB:WBPhenotype:0000697

P

From WB

GO:0045184

establishment of protein localization

WB_REF:WBPaper00004544
PMID:11050384[2]

IMP: Inferred from Mutant Phenotype

WB:WBVar00094701

P

From WB

GO:0046777

protein autophosphorylation

WB_REF:WBPaper00026599
PMID:15916946[9]

IDA: Inferred from Direct Assay

P

From WB

GO:0051117

ATPase binding

WB_REF:WBPaper00032264
PMID:18854144[5]

IPI: Inferred from Physical Interaction

WB:WBGene00010562

F

From WB

GO:0051233

spindle midzone

WB_REF:WBPaper00004544
PMID:11050384[2]

IDA: Inferred from Direct Assay

C

From WB

GO:0051256

spindle midzone assembly involved in mitosis

WB_REF:WBPaper00004544
PMID:11050384[2]

IMP: Inferred from Mutant Phenotype

WB:WBRNAi00004980
WB:WBVar00094701

P

From WB


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Speliotes, EK et al. (2000) The survivin-like C. elegans BIR-1 protein acts with the Aurora-like kinase AIR-2 to affect chromosomes and the spindle midzone. Mol. Cell 6 211-23 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Severson, AF et al. (2000) The aurora-related kinase AIR-2 recruits ZEN-4/CeMKLP1 to the mitotic spindle at metaphase and is required for cytokinesis. Curr. Biol. 10 1162-71 PubMed GONUTS page
  3. 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 Mulder, NJ et al. (2003) The InterPro Database, 2003 brings increased coverage and new features. Nucleic Acids Res. 31 315-8 PubMed GONUTS page
  4. 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 Camon, E et al. (2003) The Gene Ontology Annotation (GOA) project: implementation of GO in SWISS-PROT, TrEMBL, and InterPro. Genome Res. 13 662-72 PubMed GONUTS page
  5. 5.0 5.1 5.2 Heallen, TR et al. (2008) An Afg2/Spaf-related Cdc48-like AAA ATPase regulates the stability and activity of the C. elegans Aurora B kinase AIR-2. Dev. Cell 15 603-16 PubMed GONUTS page
  6. 6.0 6.1 6.2 Rogers, E et al. (2002) The aurora kinase AIR-2 functions in the release of chromosome cohesion in Caenorhabditis elegans meiosis. J. Cell Biol. 157 219-29 PubMed GONUTS page
  7. Bishop, JD & Schumacher, JM (2002) Phosphorylation of the carboxyl terminus of inner centromere protein (INCENP) by the Aurora B Kinase stimulates Aurora B kinase activity. J. Biol. Chem. 277 27577-80 PubMed GONUTS page
  8. Bishop, JD et al. (2005) The Caenorhabditis elegans Aurora B kinase AIR-2 phosphorylates and is required for the localization of a BimC kinesin to meiotic and mitotic spindles. Mol. Biol. Cell 16 742-56 PubMed GONUTS page
  9. 9.0 9.1 9.2 Han, Z et al. (2005) The C. elegans Tousled-like kinase contributes to chromosome segregation as a substrate and regulator of the Aurora B kinase. Curr. Biol. 15 894-904 PubMed GONUTS page
  10. 10.0 10.1 10.2 10.3 Skop, AR et al. (2004) Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Science 305 61-6 PubMed GONUTS page
  11. 11.0 11.1 11.2 Kaitna, S et al. (2002) The aurora B kinase AIR-2 regulates kinetochores during mitosis and is required for separation of homologous Chromosomes during meiosis. Curr. Biol. 12 798-812 PubMed GONUTS page
  12. 12.0 12.1 Rual, JF et al. (2004) Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library. Genome Res. 14 2162-8 PubMed GONUTS page
  13. Fernandez, AG et al. (2005) New genes with roles in the C. elegans embryo revealed using RNAi of ovary-enriched ORFeome clones. Genome Res. 15 250-9 PubMed GONUTS page
  14. Sönnichsen, B et al. (2005) Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans. Nature 434 462-9 PubMed GONUTS page
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