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VIBCH:TCPA2

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Species (Taxon ID) Vibrio cholerae. (666)
Gene Name(s) tcpA
Protein Name(s) Toxin coregulated pilin

Pilus colonization factor

External Links
UniProt P23024
EMBL M33514
X64098
PDB 1OQV
1QQZ
PDBsum 1OQV
1QQZ
ProteinModelPortal P23024
SMR P23024
EvolutionaryTrace P23024
GO GO:0043230
GO:0009289
GO:0009405
InterPro IPR012902
IPR001120
IPR010271
Pfam PF05946
TIGRFAMs TIGR02532
PROSITE PS00409

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0051701

interaction with host

PMID:12055286[1]

ECO:0000315

P

With variant strains of V. Cholera, the TcpA structure is required for intestinal colonization as a colonization factor. TcpA is a critical determinant of the pathogenicity of V. cholerae upon intragastrically inoculating suckling mice(Table 4).

complete
CACAO 4657

part_of

GO:0009289

pilus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010271

C

Seeded From UniProt

complete

involved_in

GO:0009405

pathogenesis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010271

P

Seeded From UniProt

complete

part_of

GO:0043230

extracellular organelle

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010271

C

Seeded From UniProt

complete

part_of

GO:0009289

pilus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0281
UniProtKB-SubCell:SL-0113

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Boyd, EF & Waldor, MK (2002) Evolutionary and functional analyses of variants of the toxin-coregulated pilus protein TcpA from toxigenic Vibrio cholerae non-O1/non-O139 serogroup isolates. Microbiology (Reading, Engl.) 148 1655-66 PubMed GONUTS page