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User:Siriasde

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My Annotations

StatusPageDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
updatedbyinstructorPEPDI:Q45SX32013-04-09 12:00:22 CDTGO:0044650 adhesion of symbiont to host cell (P)PMID:11705981ECO:0000314 direct assay evidence used in manual assertion

Figure 1B shows adherence of Vero cells to purified GST protein (negative control), FliC, FliD, and the crude flagella. Significant adherence is seen in the purified FliD; a weaker adherence is seen in the crude flagella (both FliC and FliD). These results indicate that FliD has a role in cell adhesion during C. difficile infection.

challenge
acceptableLACLM:CLPP2013-04-11 21:25:24 CDTGO:0006515 misfolded or incompletely synthesized protein catabolic process (P)PMID:9987112ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 5 shows that a clpP mutant strain has a reduced ability to degrade puromycyl-containing polypeptides which are comparable to misfolded proteins. This indicates that ClpP degrades misfolded proteins.

challenge
updatedbyinstructorLACRE:Q9FCU52013-04-13 16:36:40 CDTGO:0044650 adhesion of symbiont to host cell (P)PMID:16861796ECO:0000314 direct assay evidence used in manual assertion

Fig 4.

challenge
updatedbyinstructorPEPDI:CH602013-04-14 14:52:55 CDTGO:0044650 adhesion of symbiont to host cell (P)PMID:11160803ECO:0000314 direct assay evidence used in manual assertion

Figure 5 shows the adhesion of C. difficile to Vero cells in the absence and presence of anti-GroEL; adhesion decreases when anti-GroEL is present indicating that GroEL is involved in the attachment of C. difficile to cells.

challenge

acceptable:1
unacceptable:0
requires_changes:0
flagged:0

Annotations challenged by Siriasde

StatusAuthor,GroupPageGO Term (Aspect)ReferenceEvidenceLinksPage history
requireschangesBobby.geiger,
Team Cytoskeleton
STRCO:FTSZGO:0000917 - division septum assembly (P)PMID:22113698ECO:0000315 mutant phenotype evidence used in manual assertionchallengeC: 4

0 annotations fixed by Siriasde

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