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User:Jordan.rausch

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My Annotations

StatusPageDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
requireschangesHUMAN:CASL2012-09-23 16:12:44 CDTGO:2000446 regulation of macrophage migration inhibitory factor signaling pathway (P)PMID:22984505ECO:0000316 genetic interaction evidence used in manual assertion

Figure 6. The results of the paper suggest that NEDD9 promotes tumor cell migration and invasion. These results suggest that NEDD9 plays a key role in facilitating MDA-MB-231 cell migration, invasion, and growth.

challenge
updatedbyinstructorHUMAN:MURC2012-09-20 15:51:39 CDTGO:0010468 regulation of gene expression (P)PMID:21642240ECO:0000315 mutant phenotype evidence used in manual assertion

Fig 3.

challenge
updatedbyinstructorHUMAN:CIKS2012-10-16 19:46:04 CDTGO:0002230 positive regulation of defense response to virus by host (P)PMID:23066157ECO:0000314 direct assay evidence used in manual assertion

Figure 3 shows that Act1/CIKS expression is induced in response to dsRNA and Figure 4 shows that Act1 and IRF3 coexpression triggers antiviral signaling

challenge
requireschangesECOLI:FTSA2012-10-16 19:42:31 CDTGO:0051301 cell division (P)PMID:22761913ECO:0000314 direct assay evidence used in manual assertion

Figure 3 shows the interactions of ftsA with lipid/membrane structures. Figure 3c specifically shows ionic strength of ftsA binding.

challenge
updatedbyinstructor?2012-10-16 16:41:52 CDTGO:0045893 positive regulation of transcription, DNA-dependent (Figure 4 shows that binding of STAT3 to the GIV promoter increases transcription of GIV)PMID:23066027IMP: Inferred from Mutant Phenotype
challenge
updatedbyinstructorHUMAN:JAK22012-10-16 19:37:57 CDTGO:0004713 protein tyrosine kinase activity (F)PMID:23061660ECO:0000314 direct assay evidence used in manual assertion

Table 3

challenge
acceptableMOUSE:KPCA2012-10-29 08:43:29 CDTGO:0004697 protein kinase C activity (F)PMID:23099255ECO:0000314 direct assay evidence used in manual assertion

Figure 5 shows the effect of euphol (100 μg/ear) on TPA-induced PKC activation. B shows alpha activation.

challenge
unacceptableMOUSE:CD42012-10-29 09:52:44 CDTGO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response (P)PMID:23100516ECO:0000314 direct assay evidence used in manual assertion

Figure 2 shows TCR and CD5 levels for

the two different CD4+ T cell lines.

challenge
updatedbyinstructorRAT:ACE22012-10-29 10:05:02 CDTGO:0004180 carboxypeptidase activity (F)PMID:22595130ECO:0000314 direct assay evidence used in manual assertion

Table 1

challenge
updatedbyinstructorHUMAN:HMGB12012-11-15 08:56:43 CSTGO:0043537 negative regulation of blood vessel endothelial cell migration (P)PMID:23148224ECO:0000314 direct assay evidence used in manual assertion

Figure 2 shows that HMGB1 inhibits HPAEC migration, which is a critical process for vascular regeneration.

challenge
unacceptableHUMAN:PKD12012-11-15 09:22:43 CSTGO:0019887 protein kinase regulator activity (F)PMID:23148218ECO:0000314 direct assay evidence used in manual assertion

Figure 2 shows that depletion of PKD1 from cells increased their ability to migrate. Data suggests that inhibition of endogenous basal PKD1 activity is a mechanism of how NRG induces cell migration.

challenge

acceptable:1
unacceptable:2
requires_changes:2
flagged:0

Annotations challenged by Jordan.rausch

StatusAuthor,GroupPageGO Term (Aspect)ReferenceEvidenceLinksPage history
unacceptableMwhitton,
Team BTHO PubMed!
DROME:PLUGO:0045977 - positive regulation of mitotic cell cycle, embryonic (P)PMID:11044392ECO:0000314 direct assay evidence used in manual assertionchallengeC: 1
requireschangesAba.bransah,
Team Roll Tide
HUMAN:HCSTGO:0035591 - signaling adaptor activity (F)PMID:20212116ECO:0000314 direct assay evidence used in manual assertionchallengeC: 1

0 annotations fixed by Jordan.rausch