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User:Heidi.Larson.1

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CACAO Spring 2016

My Annotations

StatusPageDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
unacceptableALIFS:LUXI2016-02-22 10:59:37 CSTGO:0061579 N-acyl homoserine lactone synthase activity (F)PMID:17827287ECO:0000317 genomic context evidence used in manual assertion
challenge
unacceptableVIBF1:LUXS2016-03-07 22:56:13 CSTGO:0003700 transcription factor activity, sequence-specific DNA binding (F)other:17827287ECO:0000314 direct assay evidence used in manual assertion

Fig. 2 shows direct binding of LuxR protein to promoters of genes of Lux operon

challenge
updatedbyinstructorVIBF1:Q5E2682016-03-29 03:26:00 CDTGO:0006083 acetate metabolic process (P)PMID:18487321ECO:0000315 mutant phenotype evidence used in manual assertion

Fig 5, Table 2

challenge
updatedbyinstructorVIBF1:Q5E6152016-04-12 05:10:27 CDTGO:0008218 bioluminescence (P)PMID:24056099ECO:0000316 genetic interaction evidence used in manual assertion

Fig. 2 shows that the ainR mutant has decreased luminescence. This decreased luminescence can be mediated with the addition of C8-AHL. This shows that ainR in V. fischeri acts almost identically to luxN in V. harveyi.

challenge

acceptable:0
unacceptable:2
requires_changes:0
flagged:0

Annotations challenged by Heidi.Larson.1

StatusAuthor,GroupPageGO Term (Aspect)ReferenceEvidenceLinksPage history
unacceptableBrice.Sondrol,
Team Spartan
ENTFC:VANXGO:0010628 - positive regulation of gene expression (P)PMID:8981985ECO:0000314 direct assay evidence used in manual assertionchallengeC: 3
unacceptableKonaKuaiwa,
Team Sandy Konas
SCHPO:CLR4GO:1900111 - positive regulation of histone H3-K9 dimethylation (P)PMID:26889830ECO:0000315 mutant phenotype evidence used in manual assertionchallengeC: 1
unacceptableJkane94,
Team MIA
HUMAN:CDK9GO:0050729 - positive regulation of inflammatory response (P)PMID:26859911ECO:0000314 direct assay evidence used in manual assertionchallengeC: 3
unacceptableJonathan.Yuen,
Team Not Very Creative
MYCTU:ESXAGO:0032689 - negative regulation of interferon-gamma production (P)PMID:19265145ECO:0000314 direct assay evidence used in manual assertionchallengeC: 2
unacceptableAbbey.Steckler,
Team Numero Uno
MYCTU:ESXAGO:0050868 - negative regulation of T cell activation (P)PMID:19265145ECO:0000314 direct assay evidence used in manual assertionchallengeC: 1
unacceptableAbbey.Steckler,
Team Numero Uno
MYCTU:ESXAGO:0044414 - suppression of host defenses by symbiont (P)PMID:19265145ECO:0000314 direct assay evidence used in manual assertionchallengeC: 1
unacceptableMargalit.R.Balaban,
Team The Herd
STAAU:SARAGO:0006508 - proteolysis (P)PMID:25257373ECO:0000316 genetic interaction evidence used in manual assertionchallengeC: 1
updatedbyinstructorTracy.Pham,
Team Espresso my genes
HUMAN:NLRC4GO:0097202 - activation of cysteine-type endopeptidase activity (P)PMID:15882992ECO:0000315 mutant phenotype evidence used in manual assertionchallengeC: 2
unacceptableHannah.Wagner,
Team I'm bringing sexy bacterium
STRPY:Q54958GO:0045916 - negative regulation of complement activation (P)PMID:8557634ECO:0000315 mutant phenotype evidence used in manual assertionchallengeC: 1
updatedbyinstructorHeidi.Larson.1,
Team Grapes of Staph
VIBF1:Q5E615GO:0008218 - bioluminescence (P)PMID:24056099ECO:0000316 genetic interaction evidence used in manual assertionchallengeC: 3

fixed by Heidi.Larson.1
updatedbyinstructorHeidi.Larson.1,
Team Grapes of Staph
VIBF1:Q5E268GO:0006083 - acetate metabolic process (P)PMID:18487321ECO:0000315 mutant phenotype evidence used in manual assertionchallengeC: 2

fixed by Heidi.Larson.1
unacceptableTtran13,
Team Asian persuasian
MOUSE:CTGFGO:0014028 - notochord formation (P)PMID:23839921ECO:0000315 mutant phenotype evidence used in manual assertionchallengeC: 1

2 annotations fixed by Heidi.Larson.1

What do the icons mean in the status column?

assessment icons.jpg