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User:Cece.Staley

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My Annotations

StatusPageDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
requireschangesOLICO:Q513262012-10-19 21:53:52 CDTGO:0008805 carbon-monoxide oxygenase activity (F)PMID:23077613ECO:0000314 direct assay evidence used in manual assertion

Figure 1 shows that 'Panel (A) compares the sequences of CoxD (295 aa) of O. carboxidovorans and BchI (350 aa) of R. capsulatus employing the UVa FASTA Server '

challenge
requireschangesMOUSE:MBD52012-10-19 22:32:36 CDTGO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly (P)PMID:23077600ECO:0000314 direct assay evidence used in manual assertion

Figure 2 shows that 'The Mbd5-knockout mice had significantly smaller body size than their littermates, and the reduction in body weight was accompanied by a reduction in body length.'

challenge
requireschangesHUMAN:VGFR22012-11-12 16:24:18 CSTGO:0004716 receptor signaling protein tyrosine kinase activity (F)PMID:23139789ECO:0000314 direct assay evidence used in manual assertion

Figure one shows that 'HUVECs were subjected to geldanamycin (17-DMAG) treatment for indicated times, lysed and processed for immunoblotting (IB) to analyze indicated protein levels. Arrowhead indicates mature VEGFR2; TfR, transferrin receptor. (B) Quantification of mature VEGFR2 levels in control and geldanamycin-treated endothelial cells'

challenge
unacceptableHUMAN:PKD12012-11-15 12:02:09 CSTGO:0004672 protein kinase activity (F)PMID:23028574ECO:0000314 direct assay evidence used in manual assertion

Figure 2 shows that '% residual PKD1 kinase activity calculated based on the total kinase activity measured in the absence of inhibitors (DMSO).'

challenge
unacceptableHUMAN:PKD12012-11-15 12:06:15 CSTGO:0004672 protein kinase activity (F)PMID:23028574ECO:0000314 direct assay evidence used in manual assertion

Table 1 shows 'PKD1 selective inhibitors with little or no inhibitory activity for PKCα, PKCδ or CAMKIIα.'

challenge
requireschangesMOUSE:PKD22012-11-15 12:25:57 CSTGO:0004672 protein kinase activity (F)PMID:22311617ECO:0000269 experimental evidence used in manual assertion

Figure 3 shows 'in vitro migration and in vivo trafficking of WT and PKD2-deficient lymphocytes to secondary lymphoid tissues.'

challenge
unacceptableMOUSE:PKD22012-11-15 12:32:00 CSTGO:0004672 protein kinase activity (F)PMID:22233340ECO:0000314 direct assay evidence used in manual assertion

Figure 1 shows that 'PKD2 regulates thymic output.'

challenge
unacceptableMOUSE:PKD22012-11-15 12:35:59 CSTGO:0004672 protein kinase activity (F)PMID:22233340ECO:0000314 direct assay evidence used in manual assertion

Figure 5 shows the 'role of PKD2 in thymus development of TCR transgenic mice.'

challenge

acceptable:0
unacceptable:4
requires_changes:4
flagged:0

Annotations challenged by Cece.Staley

StatusAuthor,GroupPageGO Term (Aspect)ReferenceEvidenceLinksPage history

0 annotations fixed by Cece.Staley