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TRYBB:O76290
Contents
| Species (Taxon ID) | Trypanosoma brucei brucei. (5702) | |
| Gene Name(s) | PTR1 (ECO:0000313 with EMBL:AAC23562.1) | |
| Protein Name(s) | Pteridine reductase (ECO:0000313 with EMBL:AAC23562.1) | |
| External Links | ||
| UniProt | O76290 | |
| EMBL | AF049903 | |
| PDB | 2C7V 2VZ0 2WD7 2WD8 2X9G 2X9N 2X9V 2YHU 3BMC 3BMN 3BMO 3BMQ 3GN1 3GN2 3MCV | |
| PDBsum | 2C7V 2VZ0 2WD7 2WD8 2X9G 2X9N 2X9V 2YHU 3BMC 3BMN 3BMO 3BMQ 3GN1 3GN2 3MCV | |
| ProteinModelPortal | O76290 | |
| SMR | O76290 | |
| STRING | 5691.Tb927.8.2210 | |
| BindingDB | O76290 | |
| EvolutionaryTrace | O76290 | |
| GO | GO:0000166 GO:0016491 | |
| Gene3D | 3.40.50.720 | |
| InterPro | IPR002198 IPR002347 IPR016040 IPR014058 IPR020904 | |
| PRINTS | PR00081 PR00080 | |
| TIGRFAMs | TIGR02685 | |
| PROSITE | PS00061 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0047040 |
pteridine reductase activity |
ECO:0000315 |
F |
Using figures 2 and 3 to determine the function for PTR1. Figure 2 shows the production of tetracycline with and without PTR1 in the cells and their resulting virulence in Figure 4. Figure 3 shows the enzyme activity of PTR1. |
complete | |||||
|
enables |
GO:0047040 |
pteridine reductase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0016491 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0047040 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000323 |
imported automatically asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Sienkiewicz, N et al. (2010) Trypanosoma brucei pteridine reductase 1 is essential for survival in vitro and for virulence in mice. Mol. Microbiol. 77 658-71 PubMed GONUTS page
