PMID:9674432

Citation	Boutros, M, Paricio, N, Strutt, DI and Mlodzik, M (1998) Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell 94:109-18
Abstract	Frizzled family proteins have been described as receptors of Wnt signaling molecules. In Drosophila, the two known Frizzled proteins are associated with distinct developmental processes. Genesis of epithelial planar polarity requires Frizzled, whereas Dfz2 affects morphogenesis by wingless-mediated signaling. Dishevelled is required in both signaling pathways. Here, we use genetic and overexpression assays to show that Dishevelled activates JNK cascades. Rescue analysis reveals different protein domain requirements in Dishevelled for the two pathways; the C-terminal DEP domain is essential to rescue planar polarity defects and induce JNK signaling. Furthermore, the planar polarity-specific dsh1 allele is mutated in the DEP domain. Our results indicate that different Wnt/Fz signals activate distinct intracellular pathways, and Dishevelled discriminates among them by distinct domain interactions.
Links	PubMed
Keywords	Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Body Patterning/genetics; Calcium-Calmodulin-Dependent Protein Kinases/metabolism; Drosophila/genetics; Drosophila Proteins; Eye/embryology; Frizzled Receptors; Insect Proteins/genetics; Insect Proteins/metabolism; JNK Mitogen-Activated Protein Kinases; Membrane Proteins/metabolism; Mitogen-Activated Protein Kinases; Models, Genetic; Molecular Sequence Data; Phosphoproteins/genetics; Phosphoproteins/metabolism; Phosphorylation; Point Mutation; Proto-Oncogene Proteins/metabolism; Receptors, G-Protein-Coupled; Sequence Homology, Amino Acid; Signal Transduction; Wnt1 Protein
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