GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
Cacao
GO:0048260 | positive regulation of receptor-mediated endocytosis | PMID:22078883 | IDA: Inferred from Direct Assay | P | ||||
This annotation made on page: MOUSE:CD14 By: Drl5141 (group Team Protein Titans) on 2014-02-11 19:48:45 CST. |
You must be logged in to challenge this annotation.
Entry Type | Challenging User,Group | Time/Date | Challenge Reason | Points/Assessment |
---|---|---|---|---|
Challenge | Mcfadd48, MichSt14A 40 | 2014-04-08 11:11:41 CDT | The GO Term GO:0048260 -- positive regulation of receptor-mediated endocytosis - is correct for this entry. The correct Evidence Code is IMP: Inferred from Mutant Phenotype. Figures 1A and 1B show that LPS induced the rapid endocytosis of TLR4 in wild-type macrophages and dendritic cells, but in CD14 knockout cells, this response was not observed. This response was specific to TLR4, as Fc-gamma R1 receptor levels were not changed by LPS treatment. This shows that CD14 is required for the endocytosis of TLR4 in response to LPS. | 0 |
Challenge | Djgulizia, Team Texas Aggies | 2014-03-26 21:35:59 CDT | GO:0038010 -- positive regulation of signal transduction by receptor internalization because the internalization of TLR4 induces a number of different responses within the cell. When CD14 was absent, these processes (like IFN production) were lost or deficient. | 0 |
Challenge | Djgulizia, Team Texas Aggies | 2014-03-04 20:40:26 CST | GO:0002092 positive regulation of receptor internalization Evidence: IMP | 1 |
Private Assessment | Suzialeksander | 2014-05-09 13:54:41 CDT | You need to be an instructor to view these notes. | Updated by Instructor |
Private Assessment | Shabnam | 2014-04-08 19:56:18 CDT | You need to be an instructor to view these notes. | Requires Changes ✗ Go term |
Public Assessment | DanielRenfro | 2014-04-08 11:11:41 CDT | This annotation has been flagged because it has been edited since last assessment ||GO:0048260||positive regulation of receptor-mediated endocytosis||PMID:22078883||IDA: Inferred from Direct Assay||||P||With stimulation with LPS of CD14 there was an increase internalization of TLR4 receptors as shown in figure 1 A and B graphs 3 in each macrophages and dendritic cells. ||complete | Flagged |
Private Assessment | Briddle24 | 2014-04-01 20:10:15 CDT | You need to be an instructor to view these notes. | Requires Changes ✗ Go term |
Public Assessment | DanielRenfro | 2014-03-26 21:35:59 CDT | This annotation has been flagged because it has been edited since last assessment ||GO:0048260||positive regulation of receptor-mediated endocytosis||PMID:22078883||IDA: Inferred from Direct Assay||||P||With stimulation with LPS of CD14 there was an increase internalization of TLR4 receptors as shown in figure 1 A and B graphs 3 in each macrophages and dendritic cells. ||complete | Flagged |
Private Assessment | Suzialeksander | 2014-03-18 20:23:15 CDT | You need to be an instructor to view these notes. | Requires Changes ✗ Go term |
Public Assessment | DanielRenfro | 2014-03-04 20:40:27 CST | This annotation has been flagged because it has been edited since last assessment ||GO:0048260||positive regulation of receptor-mediated endocytosis||PMID:22078883||IDA: Inferred from Direct Assay||||P||With stimulation with LPS of CD14 there was an increase internalization of TLR4 receptors as shown in figure 1 A and B graphs 3 in each macrophages and dendritic cells. ||complete | Flagged |
Private Assessment | Suzialeksander | 2014-02-24 15:39:55 CST | You need to be an instructor to view these notes. | Requires Changes ✔ Protein ✔ Publication ✔ Qualifier ✗ Go term ✗ Evidence ✔ With/From ✔ Notes |
Private Assessment | Kathrynmartin | 2014-02-18 20:46:31 CST | You need to be an instructor to view these notes. | Flagged ✔ Protein ✔ Publication ✔ Qualifier ✗ Evidence ✔ With/From |