GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
|GO:0048023||positive regulation of melanin biosynthetic process||PMID:21949658||IGI: Inferred from Genetic Interaction UniProtKB:P07147 UniProtKB:Q60696||P|
|This annotation made on page: MOUSE:ASIP|
By: Emlarkin03 (group Team Angry Squirrels) on 2011-10-18 19:54:26 CDT.
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|Entry Type||Challenging User,Group||Time/Date||Challenge Reason||Points/Assessment|
|2011-10-25 21:57:09 CDT|
The evidence code should be IMP because the table is only comparing WT to -/- PMEL mutant.
|Bmcintosh||2011-11-18 13:40:19 CST|
We agree with the original annotation - the authors state "No consistent difference in pheomelanin-content was noted among Pmel genotypes; by comparison, homozygosity for the non-agouti allele at the Asip locus caused a drastic reduction in pheomelanin content (Table 2)." Thus, it takes mutations in more than 1 gene to see the altered phenotype.