GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
|GO:0003712||transcription cofactor activity||PMID:21909421||IDA: Inferred from Direct Assay||F|
|This annotation made on page: HUMAN:FUS|
By: Mdao3 (group Team That Will Beat You!!!) on 2011-10-09 16:37:45 CDT.
|Team That Will Beat You!!!||5|
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|Entry Type||Challenging User,Group||Time/Date||Challenge Reason||Points/Assessment|
|2011-10-18 20:21:18 CDT|
See reasons given in my assessment.
|2011-10-18 19:43:09 CDT|
Fig 4 shows that increased expression of FUS can affect on activity of AR, but it does not prove if they have direct interaction. GO:0003712 term includes proteins mediate protein-protein interactions between regulatory transcription factors.
|Mkline||2012-03-27 12:19:16 CDT||You need to be an instructor to view these notes.||Acceptable|
|Davidmigl||2011-10-18 20:17:54 CDT|
The following is a direct quote from the GO term definition: " [Proteins with 'transcription cofactor activity'] mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." Thus, it is expected that some protein interactions would have to be demonstrated for this GO term to apply. The authors did indeed do this with co-IP and mass spec experiments (figure 1). Additionally, figure 3 establishes the ability of FUS to regulate transcription. It is baffling that neither team mentioned either of these figures. The full set of evidence for this particular GO term is figures 1, 3, and 4. 3/5 points awarded to the original team for an incomplete annotation. 2/5 points awarded to the challenging team for identifying a problem, but they should have suggested a better annotation, too.