GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
The row for this annotation cannot be found. This might be due to a row or page getting deleted.
|GO:0043085||positive regulation of catalytic activity||PMID:21909421||IDA: Inferred from Direct Assay||P|
|This annotation made on page: |
By: Mdao3 (group Team That Will Beat You!!!) on 2011-10-09 16:23:01 CDT.
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|Entry Type||Challenging User,Group||Time/Date||Challenge Reason||Points/Assessment|
Team UCL-Maple Leafs
|2011-10-16 15:11:38 CDT|
In figure 3, another possible GO term can be `transcription from RNA polymerase II promoter` (GO:0006366). Figure 3A, Luciferase activity was measured by using two different constructs of FUS (FUS-N and FUS-C), both fragments displayed activities compared to full length of FUS.
|Mkline||2012-03-27 12:13:32 CDT||You need to be an instructor to view these notes.||Acceptable|
|Davidmigl||2011-10-18 20:29:40 CDT|
"Positive regulation of catalytic activity" is a term that applies to regulation of enzymes. The protein in question is transcriptional co-activator, not an enzyme, so Mdao3's annotation is incorrect. 5 points awarded to challenging team for both identifying a problem and suggesting a solution. However, I would add that a better term would be GO:0003713, since FUS is not acting as a transcription factor but a transcriptional co-activator.