Cacao

Protein Name: c-Myc Uniprot ID: P01108 PMID: 26691508 Paper name: Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors GO ID: GO:0001228 (DNA-binding transcription activator activity, RNA polymerase II-specific) Evidence Code: IDA Notes: Fig. 1C and D shows that Mouse cells treated with c-Myc (a transcription factor identified in Uniprot as Myc) exhibit increased mRNA levels of the genes Wdr5 and Dpy30 relative to the control.

The correct Go Term is GO:0060261 Also to add into the Notes: This data (referring to the previous notes section) then later verified how direct binding to the promoter sequence caused positive regulation of transcription initiation, leading to the use of the more specific Go term.

The annotation is done on the wrong protein and should be as follows:

Protein Name: Myc proto-oncogene protein; c-Myc Uniprot ID: P01108 Organism: Mus musculus (Mouse) PMID: 26691508 Paper name: Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors GO ID: term name: GO:0045944 Evidence Code: IDA Notes: In Figure 1, more specifically 1C, it is shown how Myc proto-oncogene protein/c-Myc in Mus musculus upregulates Wdr5 and Dpy30 expression at the RNA level. With Myc proto-oncogene protein/c-Myc significantly having an impact on how the other transcription factors acted, as shown by Figure 1E.