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GO:0020002host cell plasma membranePMID:26471254IDA: Inferred from Direct Assay C
This annotation made on page: BPMD2:HOLIN
By: Varillaz (group Team Phergalicious) on 2017-04-26 19:56:16 CDT.




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Entry TypeChallenging User,GroupTime/DateChallenge ReasonPoints/Assessment
ChallengeKvieira,
Team Drexel 17A
2017-05-11 11:33:01 CDT

The chosen report does not support holin as a cellular component of the host cell plasma membrane. However, it does show that coexpression with gp10, and endolysin, results in increased bacterial cell lysis. Therefore, a better GO ID might be GO:0044659 for "cytolysis by virus of host cell". Fig 2e of the same paper shows that the density of the bacteria decreases in the vector containing gp10(endolysin) and gp11 (holin), as compared to a vector containing just gp10, thus supporting gp11 involvement in host cell lysis.

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DanielRenfro2017-05-11 11:33:01 CDT

This annotation has been flagged because it has been challenged since last assessment

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Assessment
AAJohnson2017-05-07 17:57:00 CDT

I don't see anything in this figure that suggests the recombinantly expressed proteins are present in the membrane of the host cell.

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