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Cacao

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GO:0038016insulin receptor internalizationPMID:27110488IMP: Inferred from Mutant Phenotype P
This annotation made on page: MOUSE:CAV1
By: CSears (group Team Girl, you trypsin) on 2017-02-21 09:37:14 CST.




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Entry TypeChallenging User,GroupTime/DateChallenge ReasonPoints/Assessment
ChallengeTheBockster,
Team Daytona Bronze Viper
2017-03-07 13:36:40 CST

This annotation's notes cite the wrong figures to support the claim that CAV1 is associated with insulin receptor internalization. The notes should instead cite Figure 5G and Supplemental Movie 4. This is because the article states that "Stable MIN6 cell lines expressing Cav1 mutants showed that the expression of the phospho-mimetic Cav1-Y14D mutant leads to a significantly shorter lifetime of InsRA domains at the plasma membrane compared to controls (Figure 5G, Supplemental Movie 4). *These data* are consistent with the concept that *Cav1 phosphorylation promotes insulin receptor internalization* in beta-cells."

0
Private
Assessment
Suzialeksander2017-04-26 12:52:04 CDTYou need to be an instructor to view these notes.Acceptable
Protein
Publication
Qualifier
Go term
Evidence
With/From
Notes
Unique/Original
Public
Assessment
DanielRenfro2017-03-21 13:50:13 CDT

This annotation has been flagged because it has been edited since last assessment

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0038016 insulin receptor internalization PMID:27110488 IMP: Inferred from Mutant Phenotype P Figure 5D-F: Overexpression of mutant mouse CAV-1 results in increased domain density of the insulin receptor, increased size of insulin receptor domains, and increased numbers of insulin receptors present on the plasma membrane, indicating a decrease in insulin receptor internalization with the nonfunctional protein. complete
CACAO 12293
on MOUSE:CAV1
Flagged
Public
Assessment
DanielRenfro2017-03-07 13:36:40 CST

This annotation has been flagged because it has been challenged since last assessment

Flagged
Private
Assessment
Suzialeksander2017-03-03 16:34:21 CSTYou need to be an instructor to view these notes.Requires Changes
Protein
Publication
Qualifier
Go term
Evidence
With/From
Notes
Unique/Original