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Cacao

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GO:0060965negative regulation of gene silencing by miRNAPMID:18951094IMP: Inferred from Mutant Phenotype P
This annotation made on page: HUMAN:LN28B
By: RazMonk (group Team Gene String) on 2017-02-14 13:56:09 CST.




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Entry TypeChallenging User,GroupTime/DateChallenge ReasonPoints/Assessment
ChallengeCSears,
Team Girl, you trypsin		2017-04-18 17:54:41 CDT
  • GO:0050779 RNA destabilization
  • Figure 4B: Human Lin28b (from recombinant E. coli), when added to cell extract in increasing amounts, increases the amount of uridylated pre-let-7a-1 (up-let-7a-1). Figure 4E: up-let-7a-1 shows decreased stability as compared to pre-let-7a-1. According to the authors, this indicates that "Lin28 mediates the terminal uridylation of pre-let-7 diverting the Dicer processing and irreversibly reroutes pre-let-7 into a decay pathway."
  • IDA
5
Private
Assessment		Suzialeksander2017-06-13 14:04:21 CDTYou need to be an instructor to view these notes.Updated by Instructor
Private
Assessment		JimHu2017-04-22 18:55:38 CDTYou need to be an instructor to view these notes.Corrected Through Challenges
✔ Protein
✔ Publication
✔ Qualifier
✔ Go term
✔ Evidence
✔ With/From
✔ Notes
✔ Unique/Original
Public
Assessment		DanielRenfro2017-04-18 17:54:41 CDT

This annotation has been flagged because it has been challenged since last assessment

Flagged
Private
Assessment		JimHu2017-04-18 14:12:34 CDTYou need to be an instructor to view these notes.Requires Changes
✔ Protein
✔ Publication
✔ Qualifier
✗ Go term
✔ Evidence
✔ With/From
✗ Notes
Public
Assessment		DanielRenfro2017-04-18 14:09:34 CDT

This annotation has been flagged because it has been edited since last assessment

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0031054 pre-miRNA processing PMID:18951094 IMP: Inferred from Mutant Phenotype P "Protein knockdown was carried out against human Lin28b in Huh7 cells and mouse Lin28a in mouse ESCs." Fig. 1A shows, with knocked down human lin28b, there is a marked increase in accumulation of mature miRNA let7a species, with several known targets.

Called human Lin28b.||complete
CACAO 12254

on HUMAN:LN28B
Flagged
Public
Assessment		DanielRenfro2017-04-18 13:13:04 CDT

This annotation has been flagged because it has been edited since last assessment

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0031054 pre-miRNA processing PMID:18951094 IMP: Inferred from Mutant Phenotype P "Protein knockdown was carried out against human Lin28b in Huh7 cells and mouse Lin28a in mouse ESCs." Fig. 1A shows, with knocked down human lin28b, there is a marked decrease in accumulation of mature miRNA let7a species, with several known targets.

Called human Lin28b.||complete
CACAO 12254

on HUMAN:LN28B
Flagged
Public
Assessment		DanielRenfro2017-04-16 23:46:20 CDT

This annotation has been flagged because it has been edited since last assessment

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0031054 pre-miRNA processing PMID:18951094 IMP: Inferred from Mutant Phenotype P "Protein knockdown was carried out against human Lin28b in Huh7 cells and mouse Lin28a in mouse ESCs." Fig. 1A shows, with knocked down human lin28b, there is a marked decrease in accumulation of mature miRNA let7a species, with several known targets.

Called Lin28b or collectively as Lin28 in the paper.||complete
CACAO 12254

on HUMAN:LN28B
Flagged
Public
Assessment		DanielRenfro2017-02-28 14:18:58 CST

This annotation has been flagged because it has been edited since last assessment

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0031054 pre-miRNA processing PMID:18951094 IMP: Inferred from Mutant Phenotype P Fig. 1A shows, with knocked down human lin28b, there is a marked decrease in accumulation of mature miRNA let7a species, with several known targets.

Called Lin28b or collectively as Lin28 in the paper.||complete
CACAO 12254

on HUMAN:LN28B
Flagged
Public
Assessment		DanielRenfro2017-02-28 14:08:16 CST

This annotation has been flagged because it has been edited since last assessment

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0060965 negative regulation of gene silencing by miRNA PMID:18951094 IMP: Inferred from Mutant Phenotype P Fig. 1A shows, with knocked down human lin28b, there is a marked decrease in accumulation of mature miRNA let7a species, with several known targets.

Called Lin28b or collectively as Lin28 in the paper.||complete
CACAO 12254

on HUMAN:LN28B
Flagged
Private
Assessment		Suzialeksander2017-02-24 14:35:46 CSTYou need to be an instructor to view these notes.Requires Changes
Private
Assessment		Suzialeksander2017-02-24 14:20:54 CSTYou need to be an instructor to view these notes.Requires Changes
✔ Publication
✔ Qualifier
✗ Go term
✗ Evidence
✔ With/From
✗ Notes


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