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GO:0016787hydrolase activityPMID:17878153IDA: Inferred from Direct Assay F
This annotation made on page: BPT4:UVSW
By: Powellme (group Team TRUMP2016) on 2016-05-02 10:16:10 CDT.



TeamPoints
Team TRUMP20160




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Entry TypeChallenging User,GroupTime/DateChallenge ReasonPoints/Assessment
Private
Assessment
Suzialeksander2016-05-23 15:44:35 CDTYou need to be an instructor to view these notes.Unacceptable
Public
Assessment
AAJohnson2016-05-04 11:30:23 CDT

You actually have two annotations here. Panel A is an actual crystal structure, and I've been telling students to use IDA because determination of a crystal structure is an experiment. Please revise this annotation to describe panel A.

Panel B is a model of the closed conformation. In that case, you can submit a separate annotation using Panel B as data and the evidence code ISM. When you use ISM, the reference should be to the tool they used to make the model. See the figure legend for the tools, and links to the publications.

Go term selection- Think about a better helicase GO term? The closed conformation is modeled to interact with DNA, and contains an ATP, supporting GO:0008026 ATP-dependent DNA helicase activity annotation. For both panels, many important residues and their roles are described in the text, and could be used to support your GO term selection. I am not sure you have evidence for hydrolase without drawing in something from the text.

Your notes can be improved by adding description of what the panels are showing us, and drawing that information from the text.

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