GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

Cacao

Jump to: navigation, search
GO:0051572negative regulation of histone H3-K4 methylationPMID:26324722IDA: Inferred from Direct Assay P
This annotation made on page: HUMAN:WDR5
By: Kaylamichbrown (group Team MIA) on 2016-02-02 20:15:40 CST.



TeamPoints
Team MIA5




You must be logged in to challenge this annotation.

Entry TypeChallenging User,GroupTime/DateChallenge ReasonPoints/Assessment
ChallengeTracy.Pham,
Team Espresso my genes
2016-02-16 17:19:49 CST

GO:0035097, I think this GO term is better described for the MILL3 core complex. See Figure 5 for PTIP complex methylates histone H3 on K4.

None, yet.
Public
Assessment
Suzialeksander2016-02-17 14:08:05 CST

Has been changed by student and is now acceptable.

Acceptable
Protein
Publication
Qualifier
Go term
Evidence
With/From
Notes
Unique/Original
Public
Assessment
Suzialeksander2016-02-17 14:06:52 CST

Look at http://www.jbc.org/content/282/18/13419.long, which has already been annotated (but is a GOOD example). Fig 4 clearly supports the term "histone methyltransferase complex" by showing the individual parts on a WB.

Also, it's too late this week, but there's a hint in the far right column of the judge's assessment. She thought everything is correct except the notes, so there's no need to suggest a new GO, just suggest better notes. Remember that for future challenges.

Requires Changes
Public
Assessment
DanielRenfro2016-02-16 19:27:05 CST

This annotation has been flagged because it has been edited since last assessment

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0051572 negative regulation of histone H3-K4 methylation PMID:26324722 IDA: Inferred from Direct Assay P "The MLL3 core complex in the presence of WDR5 shows only H3K4 monomethylation activity that is stimulated in comparison with the isolated MLL3 SET domain but is ∼64-fold slower than the monomethylation rate catalyzed by the MLL1 core complex"

Fig. 1D, 1F, 6A and Table 1||complete
CACAO 11225

on HUMAN:WDR5
Flagged
Public
Assessment
DanielRenfro2016-02-16 17:19:49 CST

This annotation has been flagged because it has been challenged since last assessment

Flagged
Private
Assessment
Min.lorna2016-02-08 18:22:27 CSTYou need to be an instructor to view these notes.Requires Changes
Protein
Publication
Qualifier
Go term
Evidence
With/From
Notes
Unique/Original
Private
Assessment
Min.lorna2016-02-08 12:52:56 CSTYou need to be an instructor to view these notes.Flagged