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Cacao

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Contributes to00063333290715:3290715IDA: Inferred from Direct Assay
This annotation made on page: HUMAN:HIRP3
By: Aguiarstefanie (group Team Translators) on 2015-03-29 21:15:27 CDT.



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Entry TypeChallenging User,GroupTime/DateChallenge ReasonPoints/Assessment
Private
Assessment		JimHu2015-04-29 15:45:15 CDTYou need to be an instructor to view these notes.Requires Changes
✔ Protein
✔ Publication
✗ Qualifier
✗ Go term
✔ Evidence
✔ With/From
✗ Notes
✔ Unique/Original
Public
Assessment		DanielRenfro2015-04-14 16:28:01 CDT

This annotation has been flagged because it has been edited since last assessment

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005654 nucleus 3290715:3290715 IDA: Inferred from Direct Assay C Figure 3.b. and 3.c. indicate that four HIRIP3 siRNA causes HR defect. Even though these HIRIP3 siRNA are also correlated with off target Rad51 depletion, only siHIRIP3-5 had 7 nucleotide seed match to 3‘UTR Rad51 off-targeting. Therefore, HR defects are 3-fold enriched for antisense seed sequence complementary to Rad51. However, Figure 3.b. also indicates three siRNAs defect HR depleted Rad51 without full seed complementary to the 3’UTR. Therefore, HIRIP3 siRNAs can change the mechanisms of Rad51 off-targeting. complete
CACAO 10819
on HUMAN:HIRP3
Flagged
Private
Assessment		Suzialeksander2015-04-09 12:46:16 CDTYou need to be an instructor to view these notes.Requires Changes
✗ Publication
✗ Go term
✗ Evidence
✔ Notes


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