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STRPY:PAM

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Species (Taxon ID) Streptococcus pyogenes. (1314)
Gene Name(s) pam (synonyms: emm)
Protein Name(s) Plasminogen-binding group A streptococcal M-like protein PAM
External Links
UniProt P49054
EMBL Z22219
PIR A49545
PDB 1I5K
2DOH
2DOI
PDBsum 1I5K
2DOH
2DOI
ProteinModelPortal P49054
SMR P49054
STRING 160490.SPy_2018
PaxDb P49054
EvolutionaryTrace P49054
GO GO:0005618
GO:0005576
GO:0016020
Gene3D 1.20.58.430
InterPro IPR021965
IPR023220
IPR005877
Pfam PF12107
TIGRFAMs TIGR01168

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

Contributes to

GO:0050765

negative regulation of phagocytosis

PMID:26945067[1]

ECO:0000315

P

Figure 2

complete
CACAO 11532

GO:0031639

plasminogen activation

PMID:8244975[2]

ECO:0000314

P

Figure 8 shows that the M53 serotype containing PAM and PAM coated polyacrylamide beads showed higher plasminogen activation than the M6 protein.

complete
CACAO 11682

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005877

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

part_of

GO:0005618

cell wall

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0134
UniProtKB-SubCell:SL-0041

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Agrahari, G et al. (2016) Streptococcus pyogenes employs strain-dependent mechanisms of C3b inactivation to inhibit phagocytosis and killing of bacteria. J. Biol. Chem. PubMed GONUTS page
  2. Berge, A & Sjöbring, U (1993) PAM, a novel plasminogen-binding protein from Streptococcus pyogenes. J. Biol. Chem. 268 25417-24 PubMed GONUTS page