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STRCO:RELA

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Species (Taxon ID) Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145). (100226)
Gene Name(s) relA
Protein Name(s) GTP pyrophosphokinase

(p)ppGpp synthase ATP:GTP 3'-pyrophosphotransferase ppGpp synthase I

External Links
UniProt P52560
EMBL X87267
X92520
AL939109
PIR S70687
RefSeq NP_625792.1
ProteinModelPortal P52560
STRING 100226.SCO1513
EnsemblBacteria CAB70915
GeneID 1096939
KEGG sco:SCO1513
PATRIC 23732602
eggNOG COG0317
HOGENOM HOG000018301
InParanoid P52560
KO K00951
OMA LDWLNFV
OrthoDB EOG6SV551
PhylomeDB P52560
UniPathway UPA00908
Proteomes UP000001973
GO GO:0016597
GO:0005524
GO:0005525
GO:0008728
GO:0016301
GO:0015970
Gene3D 3.10.20.30
InterPro IPR002912
IPR012675
IPR003607
IPR006674
IPR004811
IPR007685
IPR004095
IPR012676
Pfam PF01966
PF04607
PF02824
SMART SM00471
SM00954
SUPFAM SSF81271
TIGRFAMs TIGR00691
PROSITE PS51671

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0015970

guanosine tetraphosphate biosynthetic process

PMID:9294445[1]

ECO:0000315

P

The levels of ppGpp in M600 7.5 and 15 min after amino acid depletion (223 and 347 pmol mg21[dry weight], respectively) were comparable to earlier estimates for relA+ S. coelicolor M145 (200 pmol mg 21 [dry weight]; 54) and J1929::KC301 (292 and 542 pmol mg 21 [dry weight] in duplicate experiments) and fell in the range observed for other Streptomyces species (56); in contrast, there was no detectable ppGpp in M570.

complete
CACAO 2563

involved_in

GO:0015970

guanosine tetraphosphate biosynthetic process

PMID:9294445[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000479633
UniProtKB:P9WHG9

C

Seeded From UniProt

complete

part_of

GO:0005618

cell wall

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000479633
UniProtKB:P9WHG9

C

Seeded From UniProt

complete

involved_in

GO:0015969

guanosine tetraphosphate metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004811
InterPro:IPR007685

P

Seeded From UniProt

complete

enables

GO:0008728

GTP diphosphokinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.6.5

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0342

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

involved_in

GO:0015970

guanosine tetraphosphate biosynthetic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00908

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Chakraburtty, R & Bibb, M (1997) The ppGpp synthetase gene (relA) of Streptomyces coelicolor A3(2) plays a conditional role in antibiotic production and morphological differentiation. J. Bacteriol. 179 5854-61 PubMed GONUTS page
  2. 2.0 2.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page