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STRCO:FABH3

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Species (Taxon ID) Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145). (100226)
Gene Name(s) fabH3 (ECO:0000255 with HAMAP-Rule:MF_01815)
Protein Name(s) 3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 3 (ECO:0000255 with HAMAP-Rule:MF_01815)

3-oxoacyl-[acyl-carrier-protein] synthase III protein 3 (ECO:0000255 with HAMAP-Rule:MF_01815) Beta-ketoacyl-ACP synthase III 3 (ECO:0000255 with HAMAP-Rule:MF_01815) KAS III 3 (ECO:0000255 with HAMAP-Rule:MF_01815)

External Links
UniProt O54151
EMBL AL939125
PIR T34914
RefSeq NP_630009.1
WP_011030514.1
ProteinModelPortal O54151
STRING 100226.SCO5888
EnsemblBacteria CAA16179
GeneID 1101330
KEGG sco:SCO5888
PATRIC 23741680
eggNOG COG0332
HOGENOM HOG000246674
InParanoid O54151
KO K00648
OMA KSGQCKK
OrthoDB EOG6J74XN
PhylomeDB O54151
UniPathway UPA00094
Proteomes UP000001973
GO GO:0005737
GO:0004315
GO:0033818
GO:0006633
Gene3D 3.40.47.10
HAMAP MF_01815
InterPro IPR013751
IPR013747
IPR004655
IPR016039
IPR016038
Pfam PF08545
PF08541
SUPFAM SSF53901
TIGRFAMs TIGR00747

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0033818

beta-ketoacyl-acyl-carrier-protein synthase III activity

PMID:15901703[1]

ECO:0000315

F

..we have shown for the first time a replacement of FabH with a heterologous enzyme with only 35% of amino acid identity and dramatically different acyl-CoA substrate specificity. The resulting dramatic shift in the fatty acid profile provides the first unequivocal in vivo evidence that the observed substrate specificity of FabH determines the type of fatty acid product made by a type II FAS. Figure 3. Table 1.

complete
CACAO 2589

enables

GO:0033818

beta-ketoacyl-acyl-carrier-protein synthase III activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002147059
UniProtKB:Q7KWI9
UniProtKB:Q9HYV7

F

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016039

F

Seeded From UniProt

complete

enables

GO:0004315

3-oxoacyl-[acyl-carrier-protein] synthase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004655
InterPro:IPR013751

F

Seeded From UniProt

complete

involved_in

GO:0006633

fatty acid biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004655
InterPro:IPR013751

P

Seeded From UniProt

complete

enables

GO:0033818

beta-ketoacyl-acyl-carrier-protein synthase III activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.3.1.180

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000085060

C

Seeded From UniProt

complete

involved_in

GO:0006633

fatty acid biosynthetic process

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000085060

P

Seeded From UniProt

complete

enables

GO:0033818

beta-ketoacyl-acyl-carrier-protein synthase III activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000085060

F

Seeded From UniProt

complete

enables

GO:0016746

transferase activity, transferring acyl groups

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0012

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0006629

lipid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0443

P

Seeded From UniProt

complete

involved_in

GO:0006631

fatty acid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0276

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0008152

metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0511

P

Seeded From UniProt

complete

involved_in

GO:0006633

fatty acid biosynthetic process

GO_REF:0000037
GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0275
UniPathway:UPA00094

P

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0511

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Li, Y et al. (2005) Alteration of the fatty acid profile of Streptomyces coelicolor by replacement of the initiation enzyme 3-ketoacyl acyl carrier protein synthase III (FabH). J. Bacteriol. 187 3795-9 PubMed GONUTS page
  2. Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page