STRCO:FABH3

Species (Taxon ID)	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145). (100226)
Gene Name(s)	fabH3 (ECO:0000255 with HAMAP-Rule:MF_01815)
Protein Name(s)	3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 3 (ECO:0000255 with HAMAP-Rule:MF_01815) 3-oxoacyl-[acyl-carrier-protein] synthase III protein 3 (ECO:0000255 with HAMAP-Rule:MF_01815) Beta-ketoacyl-ACP synthase III 3 (ECO:0000255 with HAMAP-Rule:MF_01815) KAS III 3 (ECO:0000255 with HAMAP-Rule:MF_01815)
External Links
UniProt	O54151
EMBL	AL939125
PIR	T34914
RefSeq	NP_630009.1 WP_011030514.1
ProteinModelPortal	O54151
STRING	100226.SCO5888
EnsemblBacteria	CAA16179
GeneID	1101330
KEGG	sco:SCO5888
PATRIC	23741680
eggNOG	COG0332
HOGENOM	HOG000246674
InParanoid	O54151
KO	K00648
OMA	KSGQCKK
OrthoDB	EOG6J74XN
PhylomeDB	O54151
UniPathway	UPA00094
Proteomes	UP000001973
GO	GO:0005737 GO:0004315 GO:0033818 GO:0006633
Gene3D	3.40.47.10
HAMAP	MF_01815
InterPro	IPR013751 IPR013747 IPR004655 IPR016039 IPR016038
Pfam	PF08545 PF08541
SUPFAM	SSF53901
TIGRFAMs	TIGR00747

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0033818	beta-ketoacyl-acyl-carrier-protein synthase III activity	PMID:15901703	ECO:0000315			F		..we have shown for the first time a replacement of FabH with a heterologous enzyme with only 35% of amino acid identity and dramatically different acyl-CoA substrate specificity. The resulting dramatic shift in the fatty acid profile provides the first unequivocal in vivo evidence that the observed substrate specificity of FabH determines the type of fatty acid product made by a type II FAS. Figure 3. Table 1.	complete CACAO 2589
enables	GO:0033818	beta-ketoacyl-acyl-carrier-protein synthase III activity		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002147059 UniProtKB:Q7KWI9 UniProtKB:Q9HYV7	F		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016039	F		Seeded From UniProt	complete
enables	GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004655 InterPro:IPR013751	F		Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004655 InterPro:IPR013751	P		Seeded From UniProt	complete
enables	GO:0033818	beta-ketoacyl-acyl-carrier-protein synthase III activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.3.1.180	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000085060	C		Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000085060	P		Seeded From UniProt	complete
enables	GO:0033818	beta-ketoacyl-acyl-carrier-protein synthase III activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000085060	F		Seeded From UniProt	complete
enables	GO:0016746	transferase activity, transferring acyl groups	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0012	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0276	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	P		Seeded From UniProt	complete
involved_in	GO:0006633	fatty acid biosynthetic process	GO_REF:0000037 GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0275 UniPathway:UPA00094	P		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0511	F		Seeded From UniProt	complete
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References

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