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STAAW:CLPP
Contents
| Species (Taxon ID) | Staphylococcus aureus (strain MW2). (196620) | |
| Gene Name(s) | clpP (ECO:0000255 with HAMAP-Rule:MF_00444) | |
| Protein Name(s) | ATP-dependent Clp protease proteolytic subunit (ECO:0000255 with HAMAP-Rule:MF_00444)
Endopeptidase Clp (ECO:0000255 with HAMAP-Rule:MF_00444) | |
| External Links | ||
| UniProt | P63786 | |
| EMBL | BA000033 | |
| RefSeq | NP_645547.1 | |
| PDB | 3ST9 3STA 4EMM 4EMP | |
| PDBsum | 3ST9 3STA 4EMM 4EMP | |
| ProteinModelPortal | P63786 | |
| SMR | P63786 | |
| STRING | 196620.MW0730 | |
| BindingDB | P63786 | |
| EnsemblBacteria | BAB94595 | |
| GeneID | 1002841 | |
| KEGG | sam:MW0730 | |
| PATRIC | 19568014 | |
| eggNOG | COG0740 | |
| HOGENOM | HOG000285833 | |
| KO | K01358 | |
| OMA | MEINLRE | |
| OrthoDB | EOG6Z3KQ0 | |
| BioCyc | SAUR196620:GJ9Z-751-MONOMER | |
| EvolutionaryTrace | P63786 | |
| Proteomes | UP000000418 | |
| GO | GO:0005737 GO:0042802 GO:0004252 | |
| Gene3D | 3.90.226.10 | |
| HAMAP | MF_00444 | |
| InterPro | IPR001907 IPR029045 IPR023562 IPR018215 | |
| PANTHER | PTHR10381 | |
| Pfam | PF00574 | |
| PRINTS | PR00127 | |
| SUPFAM | SSF52096 | |
| TIGRFAMs | TIGR00493 | |
| PROSITE | PS00382 PS00381 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0008462 |
endopeptidase Clp activity |
ECO:0000315 |
F |
Figure 2 shows septum formation inhibition in those wild type species treated with antibiotic, in mutant clp species septum formation is able to occur even when treated with an antibiotic. |
complete | |||||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004252 |
serine-type endopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004252 |
serine-type endopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000089051 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000089051 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000089051 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008236 |
serine-type peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Sass, P et al. (2011) Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ. Proc. Natl. Acad. Sci. U.S.A. 108 17474-9 PubMed GONUTS page
- ↑ Zhang, J et al. (2011) Structural switching of Staphylococcus aureus Clp protease: a key to understanding protease dynamics. J. Biol. Chem. 286 37590-601 PubMed GONUTS page