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STAAU:W8U1E4

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Species (Taxon ID) Staphylococcus aureus. (1280)
Gene Name(s) clpC (ECO:0000313 with EMBL:BAS50668.1) (synonyms: clpC_1 (ECO:0000313 with EMBL:CUF18383.1))
Protein Name(s) Clp protease ClpX (ECO:0000313 with EMBL:KMY75209.1)

Endopeptidase (ECO:0000313 with EMBL:BAS50668.1) Endopeptidase Clp ATP-binding subunit C (ECO:0000313 with EMBL:CEK43588.1)

External Links
UniProt W8U1E4
EMBL CP012593
CP010890
CP007676
CP007672
CP009828
AP014942
CDLR01000001
CFYS01000017
LN831036
LN831049
CSCK01000014
CSGH01000001
CYJR01000001
CYKZ01000002
CYNE01000001
CYNC01000001
JYAV01000001
LFEC01000430
LIGV01000017
LIGW01000012
RefSeq WP_000897132.1
STRING 158878.SAV0525
EnsemblBacteria AJC27848
AKJ48377
AKK57691
AKK60305
KII19441
KIX71450
KIX76018
KLL98271
KLM00404
KLM02963
KLM08140
KLM09455
KLM11436
KLM13978
KLM19041
KLM20581
KLM22942
KLM29479
KLM31618
KLM35166
KLM38128
KLM40322
KLM43836
KLM44626
KLM45781
KLM49717
KLM52812
KLM56664
KLM59226
KLM61715
KLM64072
KLM68063
KLM71281
KLM74920
KLM78377
KLM82615
KLM86935
KLM88703
KLM94694
KLM96724
KLM98745
KLN01574
KLN05773
KLN09811
KLN12019
KLN16895
KLN29952
KEGG saud:CH52_03130
sauf:X998_0565
eggNOG COG0542
ENOG4105C2Z
KO K03696
Proteomes UP000038569
UP000042582
UP000044367
UP000045966
UP000048318
GO GO:0005524
GO:0008233
Gene3D 1.10.1780.10
3.40.50.300
InterPro IPR003593
IPR003959
IPR019489
IPR004176
IPR001270
IPR018368
IPR028299
IPR027417
IPR001943
Pfam PF00004
PF07724
PF02861
PF10431
PF02151
PRINTS PR00300
SMART SM00382
SM01086
SUPFAM SSF52540
SSF81923
PROSITE PS00870
PS00871
PS50151

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0008233

peptidase activity

PMID:26890675[1]

ECO:0000316

F

Figure 1 shows that the left panel shows the entire complex, whereas the right panel shows a zoomed image of the cephalosporin binding pocket. The Staphylococcus aureus strain depicted in the crystal structure (PDB 3HUM) [30], Col, is the parental strain of the Colnex strain used in the current study (Table 1). Mutant residues in PBP4 identified by selection with ceftaroline or ceftobiprole are highlighted in blue. The ligand marked in yellow is cefotaxime.

Missing: with/from
CACAO 11355

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001270
InterPro:IPR003959
InterPro:IPR018368

F

Seeded From UniProt

complete

involved_in

GO:0019538

protein metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR036628

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Greninger, AL et al. (2016) Whole-Genome Sequencing of Methicillin-Resistant Staphylococcus aureus Resistant to Fifth-Generation Cephalosporins Reveals Potential Non-mecA Mechanisms of Resistance. PLoS ONE 11 e0149541 PubMed GONUTS page