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STAAU:MECI

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Species (Taxon ID) Staphylococcus aureus. (1280)
Gene Name(s) mecI
Protein Name(s) Methicillin resistance regulatory protein MecI
External Links
UniProt P68262
EMBL L14020
ProteinModelPortal P68262
SMR P68262
GO GO:0005737
GO:0003677
GO:0045892
GO:0046677
GO:0006351
Gene3D 1.10.10.10
InterPro IPR005650
IPR011991
Pfam PF03965
PIRSF PIRSF019455

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0006355

regulation of transcription, DNA-dependent

PMID:9555900[1]

ECO:0000314

P

Table 2 shows that in cells transformed with mecI, the beta-galactosidase activity of mecA-lacZ transcriptional fusion can be induced with the presence of CBAP. Furthermore, it is shown in Fig. 2 that mecI binds to a region of DNA between the mecA and mecR1 genes and protects it from DNase.

complete
CACAO 4693

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005650

F

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005650

P

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

involved_in

GO:0046677

response to antibiotic

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0046

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Sharma, VK et al. (1998) Interaction of native and mutant MecI repressors with sequences that regulate mecA, the gene encoding penicillin binding protein 2a in methicillin-resistant staphylococci. J. Bacteriol. 180 2160-6 PubMed GONUTS page