STAA8:QUEF

Species (Taxon ID)	Staphylococcus aureus (strain NCTC 8325). (93061)
Gene Name(s)	queF (ECO:0000255 with HAMAP-Rule:MF_00818)
Protein Name(s)	NADPH-dependent 7-cyano-7-deazaguanine reductase (ECO:0000255 with HAMAP-Rule:MF_00818) 7-cyano-7-carbaguanine reductase (ECO:0000255 with HAMAP-Rule:MF_00818) NADPH-dependent nitrile oxidoreductase (ECO:0000255 with HAMAP-Rule:MF_00818) PreQ(0) reductase (ECO:0000255 with HAMAP-Rule:MF_00818)
External Links
UniProt	Q2G081
EMBL	CP000253
RefSeq	WP_000930014.1 YP_499299.1
ProteinModelPortal	Q2G081
SMR	Q2G081
STRING	93061.SAOUHSC_00739
EnsemblBacteria	ABD29872
GeneID	28378974 3920984
KEGG	sao:SAOUHSC_00739
PATRIC	19579016
eggNOG	ENOG4105CSD COG0780
HOGENOM	HOG000009528
KO	K09457
OMA	TLECKEF
UniPathway	UPA00392
Proteomes	UP000008816
GO	GO:0005737 GO:0046857 GO:0033739 GO:0008616
HAMAP	MF_00818
InterPro	IPR029500 IPR016856
Pfam	PF14489
PIRSF	PIRSF027377
TIGRFAMs	TIGR03139

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0043708	cell adhesion involved in biofilm formation	PMID:27144398	ECO:0000315			P		Figure 1: MgrA is needed for clumping in S. aureus strain RN4220. Wild type, a deleted mutant and an exogenous expressed mutant were incubated in plasma and fibrinogen. The images show clumping in the wild type and mgrA expressed mutant. Figure 2: ebh is a surface protein that blocks clumping. It is repressed by mgrA (Fig 5d and 5a). Other proteins are known to block clumping and are impacted by mgrA, one being sasG and sraP (fig 8+9) Figure 11: Biofilm formation increased in mutants lacking mgrA, with the increase in ebh. This is due to the up-regulation of the protein sasG, which is one of the proteins up-regulated with ebh as a result of the deletion of mgrA. This protein increases intercellular adhesion, meaning clumping decreases but biofilm formation is enhanced (fig 12)	complete CACAO 12325
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016856	C		Seeded From UniProt	complete
involved_in	GO:0008616	queuosine biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016856 InterPro:IPR029500	P		Seeded From UniProt	complete
enables	GO:0033739	preQ1 synthase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029500	F		Seeded From UniProt	complete
enables	GO:0046857	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016856	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016856	P		Seeded From UniProt	complete
enables	GO:0033739	preQ1 synthase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.7.1.13	F		Seeded From UniProt	complete
enables	GO:0033739	preQ1 synthase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000100271	F		Seeded From UniProt	complete
involved_in	GO:0008616	queuosine biosynthetic process	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000100271	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000100271	C		Seeded From UniProt	complete
involved_in	GO:0008616	queuosine biosynthetic process	GO_REF:0000037 GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0671 UniPathway:UPA00392	P		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
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References

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