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SHIFL:Q99QF4
Contents
| Species (Taxon ID) | Shigella flexneri. (623) | |
| Gene Name(s) | ospC3 (ECO:0000313 with EMBL:CAC05795.1) | |
| Protein Name(s) | Uncharacterized protein ospC3 (ECO:0000313 with EMBL:CAC05795.1) | |
| External Links | ||
| UniProt | Q99QF4 | |
| EMBL | AL391753 | |
| RefSeq | NP_085276.1 YP_009062477.1 | |
| PaxDb | Q99QF4 | |
| GeneID | 876580 | |
| eggNOG | ENOG4105KAX ENOG4111TVR | |
| Gene3D | 1.25.40.20 | |
| InterPro | IPR036770 IPR010366 | |
| Pfam | PF06128 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0034054 |
negative regulation by symbiont of host defense-related programmed cell death |
ECO:0000315 |
P |
Organism: Shigella Flexneri protein: OspC3 Supplementary figure 1A shows that "...one of the mutants lacking ospC3 (ΔospC3) greatly enhanced cell death at 2 and 4 hr compared to the other effector mutants and YSH6000 (wild-type [WT] Shigella) (Figure S1A), suggesting that OspC3 suppresses the cell death response to Shigella infection." Host: human skin cells |
complete | |||||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Kobayashi, T et al. (2013) The Shigella OspC3 effector inhibits caspase-4, antagonizes inflammatory cell death, and promotes epithelial infection. Cell Host Microbe 13 570-83 PubMed GONUTS page
