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SGD:CDC28

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Species (Taxon ID) Saccharomyces cerevisiae (baker's yeast) (taxon:4932)
Gene Name(s) CDC28 ( synonyms: YBR160W, CDK1, HSL5, SRM5 )
Protein Name(s) Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK),
External Links
SGD S000000364

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

From SGD

GO:0000307

cyclin-dependent protein kinase holoenzyme complex

SGD_REF:S000043997
PMID:1849458[1]

IDA: Inferred from Direct Assay

C

From SGD

GO:0000307

cyclin-dependent protein kinase holoenzyme complex

SGD_REF:S000055055
PMID:2142620[2]

IDA: Inferred from Direct Assay

C

From SGD

GO:0004672

protein kinase activity

SGD_REF:S000113918
PMID:16319894[3]

IDA: Inferred from Direct Assay

F

From SGD

GO:0004672

protein kinase activity

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR002290

F

From SGD

GO:0004674

protein serine/threonine kinase activity

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR008271

F

From SGD

GO:0004674

protein serine/threonine kinase activity

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0723

F

From SGD

GO:0004693

cyclin-dependent protein kinase activity

SGD_REF:S000055055
PMID:2142620[2]

IDA: Inferred from Direct Assay

F

From SGD

GO:0004693

cyclin-dependent protein kinase activity

SGD_REF:S000124037

IEA: Inferred from Electronic Annotation

EC:2.7.11.22

F

From SGD

GO:0005524

ATP binding

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR002290
InterPro:IPR000719
InterPro:IPR017441

F

From SGD

GO:0005524

ATP binding

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

From SGD

GO:0005634

nucleus

SGD_REF:S000076346
PMID:14685274[4]

IDA: Inferred from Direct Assay

C

From SGD

GO:0005737

cytoplasm

SGD_REF:S000044622
PMID:3312233[5]

IDA: Inferred from Direct Assay

C

From SGD

GO:0005783

endoplasmic reticulum

SGD_REF:S000123048
PMID:17560371[6]

IDA: Inferred from Direct Assay

C

From SGD

GO:0005935

cellular bud neck

SGD_REF:S000072836
PMID:12554645[7]

IDA: Inferred from Direct Assay

C

From SGD

GO:0006338

chromatin remodeling

SGD_REF:S000136817
PMID:20855529[8]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0006468

protein phosphorylation

SGD_REF:S000041807
PMID:3889921[9]

IDA: Inferred from Direct Assay

P

From SGD

GO:0006468

protein phosphorylation

SGD_REF:S000041807
PMID:3889921[9]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0006468

protein phosphorylation

SGD_REF:S000113918
PMID:16319894[3]

IDA: Inferred from Direct Assay

P

From SGD

GO:0006468

protein phosphorylation

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR002290
InterPro:IPR008271
InterPro:IPR000719

P

From SGD

GO:0007049

cell cycle

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0131

P

From SGD

GO:0007067

mitosis

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0498

P

From SGD

GO:0010568

regulation of budding cell apical bud growth

SGD_REF:S000122433
PMID:17417630[10]

IGI: Inferred from Genetic Interaction

SGD:S000003723

P

From SGD

GO:0010568

regulation of budding cell apical bud growth

SGD_REF:S000122433
PMID:17417630[10]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0010569

regulation of double-strand break repair via homologous recombination

SGD_REF:S000079871
PMID:15496928[11]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0010570

regulation of filamentous growth

SGD_REF:S000041353
PMID:9891070[12]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0010571

positive regulation of DNA replication involved in S phase

SGD_REF:S000073655
PMID:12783856[13]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0010571

positive regulation of DNA replication involved in S phase

SGD_REF:S000078503
PMID:14747467[14]

IDA: Inferred from Direct Assay

P

From SGD

GO:0010571

positive regulation of DNA replication involved in S phase

SGD_REF:S000078503
PMID:14747467[14]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0010571

positive regulation of DNA replication involved in S phase

SGD_REF:S000120479
PMID:4580573[15]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0010696

positive regulation of spindle pole body separation

SGD_REF:S000043278
PMID:8887667[16]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0010696

positive regulation of spindle pole body separation

SGD_REF:S000115566
PMID:16688214[17]

IGI: Inferred from Genetic Interaction

SGD:S000000787
SGD:S000005584
SGD:S000000159

P

From SGD

GO:0010696

positive regulation of spindle pole body separation

SGD_REF:S000115566
PMID:16688214[17]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0010898

positive regulation of triglyceride catabolic process

SGD_REF:S000129072
PMID:19150427[18]

IGI: Inferred from Genetic Interaction

SGD:S000001797

P

From SGD

GO:0010898

positive regulation of triglyceride catabolic process

SGD_REF:S000129072
PMID:19150427[18]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0016192

vesicle-mediated transport

SGD_REF:S000150166
PMID:22767578[19]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0016301

kinase activity

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

F

From SGD

GO:0016310

phosphorylation

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

P

From SGD

GO:0016740

transferase activity

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

From SGD

GO:0016772

transferase activity, transferring phosphorus-containing groups

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR011009

F

From SGD

GO:0042393

histone binding

SGD_REF:S000136817
PMID:20855529[8]

IDA: Inferred from Direct Assay

F

From SGD

GO:0045892

negative regulation of transcription, DNA-dependent

SGD_REF:S000070250
PMID:12081645[20]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0045892

negative regulation of transcription, DNA-dependent

SGD_REF:S000075752
PMID:14993267[21]

IDA: Inferred from Direct Assay

P

From SGD

GO:0045892

negative regulation of transcription, DNA-dependent

SGD_REF:S000075752
PMID:14993267[21]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0045893

positive regulation of transcription, DNA-dependent

SGD_REF:S000041330
PMID:1652372[22]

IDA: Inferred from Direct Assay

P

From SGD

GO:0045893

positive regulation of transcription, DNA-dependent

SGD_REF:S000041330
PMID:1652372[22]

IGI: Inferred from Genetic Interaction

SGD:S000002553

P

From SGD

GO:0045930

negative regulation of mitotic cell cycle

SGD_REF:S000053884
PMID:10074450[23]

IDA: Inferred from Direct Assay

P

From SGD

GO:0045931

positive regulation of mitotic cell cycle

SGD_REF:S000043253
PMID:7002718[24]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0045931

positive regulation of mitotic cell cycle

SGD_REF:S000049304
PMID:2165600[25]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0051301

cell division

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0132

P

From SGD

GO:0051446

positive regulation of meiotic cell cycle

SGD_REF:S000041086
PMID:2680756[26]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0051446

positive regulation of meiotic cell cycle

SGD_REF:S000117195
PMID:16814718[27]

IDA: Inferred from Direct Assay

P

From SGD

GO:0051446

positive regulation of meiotic cell cycle

SGD_REF:S000117195
PMID:16814718[27]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0051447

negative regulation of meiotic cell cycle

SGD_REF:S000070250
PMID:12081645[20]

IMP: Inferred from Mutant Phenotype

P

From SGD

colocalizes_with

GO:0000235

astral microtubule

SGD_REF:S000077094
PMID:15256500[28]

IDA: Inferred from Direct Assay

C

From SGD

colocalizes_with

GO:0005816

spindle pole body

SGD_REF:S000072836
PMID:12554645[7]

IDA: Inferred from Direct Assay

C

From SGD

colocalizes_with

GO:0005840

ribosome

SGD_REF:S000115662
PMID:16702403[29]

IDA: Inferred from Direct Assay

C

From SGD


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Ghiara, JB et al. (1991) A cyclin B homolog in S. cerevisiae: chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis. Cell 65 163-74 PubMed GONUTS page
  2. 2.0 2.1 Wittenberg, C et al. (1990) G1-specific cyclins of S. cerevisiae: cell cycle periodicity, regulation by mating pheromone, and association with the p34CDC28 protein kinase. Cell 62 225-37 PubMed GONUTS page
  3. 3.0 3.1 Ptacek, J et al. (2005) Global analysis of protein phosphorylation in yeast. Nature 438 679-84 PubMed GONUTS page
  4. Wang, H et al. (2004) Recruitment of Cdc28 by Whi3 restricts nuclear accumulation of the G1 cyclin-Cdk complex to late G1. EMBO J. 23 180-90 PubMed GONUTS page
  5. Wittenberg, C et al. (1987) Subcellular localization of a protein kinase required for cell cycle initiation in Saccharomyces cerevisiae: evidence for an association between the CDC28 gene product and the insoluble cytoplasmic matrix. J. Cell Biol. 105 1527-38 PubMed GONUTS page
  6. Vergés, E et al. (2007) Cyclin Cln3 is retained at the ER and released by the J chaperone Ydj1 in late G1 to trigger cell cycle entry. Mol. Cell 26 649-62 PubMed GONUTS page
  7. 7.0 7.1 Maekawa, H et al. (2003) Yeast Cdk1 translocates to the plus end of cytoplasmic microtubules to regulate bud cortex interactions. EMBO J. 22 438-49 PubMed GONUTS page
  8. 8.0 8.1 Chaves, S et al. (2010) Cks1, Cdk1, and the 19S proteasome collaborate to regulate gene induction-dependent nucleosome eviction in yeast. Mol. Cell. Biol. 30 5284-94 PubMed GONUTS page
  9. 9.0 9.1 Reed, SI et al. (1985) Protein kinase activity associated with the product of the yeast cell division cycle gene CDC28. Proc. Natl. Acad. Sci. U.S.A. 82 4055-9 PubMed GONUTS page
  10. 10.0 10.1 McCusker, D et al. (2007) Cdk1 coordinates cell-surface growth with the cell cycle. Nat. Cell Biol. 9 506-15 PubMed GONUTS page
  11. Ira, G et al. (2004) DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1. Nature 431 1011-7 PubMed GONUTS page
  12. Edgington, NP et al. (1999) Control of Saccharomyces cerevisiae filamentous growth by cyclin-dependent kinase Cdc28. Mol. Cell. Biol. 19 1369-80 PubMed GONUTS page
  13. Benjamin, KR et al. (2003) Control of landmark events in meiosis by the CDK Cdc28 and the meiosis-specific kinase Ime2. Genes Dev. 17 1524-39 PubMed GONUTS page
  14. 14.0 14.1 Kesti, T et al. (2004) Cell cycle-dependent phosphorylation of the DNA polymerase epsilon subunit, Dpb2, by the Cdc28 cyclin-dependent protein kinase. J. Biol. Chem. 279 14245-55 PubMed GONUTS page
  15. Hartwell, LH (1973) Three additional genes required for deoxyribonucleic acid synthesis in Saccharomyces cerevisiae. J. Bacteriol. 115 966-74 PubMed GONUTS page
  16. Lim, HH et al. (1996) Spindle pole body separation in Saccharomyces cerevisiae requires dephosphorylation of the tyrosine 19 residue of Cdc28. Mol. Cell. Biol. 16 6385-97 PubMed GONUTS page
  17. 17.0 17.1 Crasta, K et al. (2006) Cdk1 regulates centrosome separation by restraining proteolysis of microtubule-associated proteins. EMBO J. 25 2551-63 PubMed GONUTS page
  18. 18.0 18.1 Kurat, CF et al. (2009) Cdk1/Cdc28-dependent activation of the major triacylglycerol lipase Tgl4 in yeast links lipolysis to cell-cycle progression. Mol. Cell 33 53-63 PubMed GONUTS page
  19. McCusker, D et al. (2012) Cdk1-dependent control of membrane-trafficking dynamics. Mol. Biol. Cell 23 3336-47 PubMed GONUTS page
  20. 20.0 20.1 Purnapatre, K et al. (2002) The CLN3/SWI6/CLN2 pathway and SNF1 act sequentially to regulate meiotic initiation in Saccharomyces cerevisiae. Genes Cells 7 675-91 PubMed GONUTS page
  21. 21.0 21.1 Geymonat, M et al. (2004) Clb6/Cdc28 and Cdc14 regulate phosphorylation status and cellular localization of Swi6. Mol. Cell. Biol. 24 2277-85 PubMed GONUTS page
  22. 22.0 22.1 Moll, T et al. (1991) The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SWI5. Cell 66 743-58 PubMed GONUTS page
  23. Jaspersen, SL et al. (1999) Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14. Curr. Biol. 9 227-36 PubMed GONUTS page
  24. Reed, SI (1980) The selection of S. cerevisiae mutants defective in the start event of cell division. Genetics 95 561-77 PubMed GONUTS page
  25. Reed, SI & Wittenberg, C (1990) Mitotic role for the Cdc28 protein kinase of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A. 87 5697-701 PubMed GONUTS page
  26. Shuster, EO & Byers, B (1989) Pachytene arrest and other meiotic effects of the start mutations in Saccharomyces cerevisiae. Genetics 123 29-43 PubMed GONUTS page
  27. 27.0 27.1 Henderson, KA et al. (2006) Cyclin-dependent kinase directly regulates initiation of meiotic recombination. Cell 125 1321-32 PubMed GONUTS page
  28. Maekawa, H & Schiebel, E (2004) Cdk1-Clb4 controls the interaction of astral microtubule plus ends with subdomains of the daughter cell cortex. Genes Dev. 18 1709-24 PubMed GONUTS page
  29. Fleischer, TC et al. (2006) Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Genes Dev. 20 1294-307 PubMed GONUTS page
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