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SGD:CDC12

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Species (Taxon ID) Saccharomyces cerevisiae (baker's yeast) (taxon:4932)
Gene Name(s) CDC12 ( synonyms: YHR107C, CLA10, PSL7, septin CDC12 )
Protein Name(s) Component of the septin ring that is required for cytokinesis,
External Links
SGD S000001149

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000144

cellular bud neck septin ring

SGD_REF:S000055476
PMID:3316985[1]

IDA: Inferred from Direct Assay

C

From SGD

GO:0000166

nucleotide binding

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

From SGD

GO:0000921

septin ring assembly

SGD_REF:S000077127
PMID:14993234[2]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0003924

GTPase activity

SGD_REF:S000077127
PMID:14993234[2]

IDA: Inferred from Direct Assay

F

From SGD

GO:0005198

structural molecule activity

SGD_REF:S000126669
PMID:18550837[3]

IDA: Inferred from Direct Assay

F

From SGD

GO:0005525

GTP binding

SGD_REF:S000121415
PMID:14597621[4]

IDA: Inferred from Direct Assay

F

From SGD

GO:0005525

GTP binding

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR000038

F

From SGD

GO:0005525

GTP binding

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0342

F

From SGD

GO:0005545

1-phosphatidylinositol binding

SGD_REF:S000072964
PMID:12665577[5]

IDA: Inferred from Direct Assay

F

From SGD

GO:0005737

cytoplasm

SGD_REF:S000069459
PMID:11914276[6]

IDA: Inferred from Direct Assay

C

From SGD

GO:0005935

cellular bud neck

SGD_REF:S000148671

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0029

C

From SGD

GO:0005937

mating projection

SGD_REF:S000126719
PMID:18552279[7]

IDA: Inferred from Direct Assay

C

From SGD

GO:0007049

cell cycle

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR000038

P

From SGD

GO:0007049

cell cycle

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0131

P

From SGD

GO:0016020

membrane

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

From SGD

GO:0016020

membrane

SGD_REF:S000148671

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0162

C

From SGD

GO:0030011

maintenance of cell polarity

SGD_REF:S000044053
PMID:10882120[8]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0031105

septin complex

SGD_REF:S000052983
PMID:9813094[9]

IPI: Inferred from Physical Interaction

SGD:S000004306

C

From SGD

GO:0031105

septin complex

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR016491

C

From SGD

GO:0031105

septin complex

SGD_REF:S000126669
PMID:18550837[3]

IDA: Inferred from Direct Assay

C

From SGD

GO:0032160

septin filament array

SGD_REF:S000077562
PMID:15282341[10]

IDA: Inferred from Direct Assay

C

From SGD

GO:0032947

protein complex scaffold

SGD_REF:S000039417
PMID:9442111[11]

IMP: Inferred from Mutant Phenotype

F

From SGD

GO:0033205

cell cycle cytokinesis

SGD_REF:S000073001
PMID:12636916[12]

IDA: Inferred from Direct Assay

P

From SGD

GO:0045860

positive regulation of protein kinase activity

SGD_REF:S000074229
PMID:14527412[13]

IDA: Inferred from Direct Assay

P

From SGD

GO:0051301

cell division

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0132

P

From SGD


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Haarer, BK & Pringle, JR (1987) Immunofluorescence localization of the Saccharomyces cerevisiae CDC12 gene product to the vicinity of the 10-nm filaments in the mother-bud neck. Mol. Cell. Biol. 7 3678-87 PubMed GONUTS page
  2. 2.0 2.1 Versele, M & Thorner, J (2004) Septin collar formation in budding yeast requires GTP binding and direct phosphorylation by the PAK, Cla4. J. Cell Biol. 164 701-15 PubMed GONUTS page
  3. 3.0 3.1 Bertin, A et al. (2008) Saccharomyces cerevisiae septins: supramolecular organization of heterooligomers and the mechanism of filament assembly. Proc. Natl. Acad. Sci. U.S.A. 105 8274-9 PubMed GONUTS page
  4. Vrabioiu, AM et al. (2004) The majority of the Saccharomyces cerevisiae septin complexes do not exchange guanine nucleotides. J. Biol. Chem. 279 3111-8 PubMed GONUTS page
  5. Casamayor, A & Snyder, M (2003) Molecular dissection of a yeast septin: distinct domains are required for septin interaction, localization, and function. Mol. Cell. Biol. 23 2762-77 PubMed GONUTS page
  6. Kumar, A et al. (2002) Subcellular localization of the yeast proteome. Genes Dev. 16 707-19 PubMed GONUTS page
  7. Bharucha, JP et al. (2008) Saccharomyces cerevisiae Afr1 protein is a protein phosphatase 1/Glc7-targeting subunit that regulates the septin cytoskeleton during mating. Eukaryotic Cell 7 1246-55 PubMed GONUTS page
  8. Barral, Y et al. (2000) Compartmentalization of the cell cortex by septins is required for maintenance of cell polarity in yeast. Mol. Cell 5 841-51 PubMed GONUTS page
  9. Frazier, JA et al. (1998) Polymerization of purified yeast septins: evidence that organized filament arrays may not be required for septin function. J. Cell Biol. 143 737-49 PubMed GONUTS page
  10. Versele, M et al. (2004) Protein-protein interactions governing septin heteropentamer assembly and septin filament organization in Saccharomyces cerevisiae. Mol. Biol. Cell 15 4568-83 PubMed GONUTS page
  11. Lippincott, J & Li, R (1998) Sequential assembly of myosin II, an IQGAP-like protein, and filamentous actin to a ring structure involved in budding yeast cytokinesis. J. Cell Biol. 140 355-66 PubMed GONUTS page
  12. Dobbelaere, J et al. (2003) Phosphorylation-dependent regulation of septin dynamics during the cell cycle. Dev. Cell 4 345-57 PubMed GONUTS page
  13. Hanrahan, J & Snyder, M (2003) Cytoskeletal activation of a checkpoint kinase. Mol. Cell 12 663-73 PubMed GONUTS page
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