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SGD:CCR4

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Species (Taxon ID) Saccharomyces cerevisiae (baker's yeast) (taxon:4932)
Gene Name(s) CCR4 ( synonyms: YAL021C, FUN27, NUT21 )
Protein Name(s) Component of the CCR4-NOT transcriptional complex,
External Links
SGD S000000019

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000076

DNA replication checkpoint

SGD_REF:S000120021
PMID:17158920[1]

IGI: Inferred from Genetic Interaction

SGD:S000000566
SGD:S000000184

P

From SGD

GO:0000175

3'-5'-exoribonuclease activity

SGD_REF:S000059912
PMID:11239395[2]

IMP: Inferred from Mutant Phenotype

F

From SGD

GO:0000175

3'-5'-exoribonuclease activity

SGD_REF:S000069437
PMID:11889048[3]

IDA: Inferred from Direct Assay

F

From SGD

GO:0000175

3'-5'-exoribonuclease activity

SGD_REF:S000069437
PMID:11889048[3]

IGI: Inferred from Genetic Interaction

SGD:S000005335

F

From SGD

GO:0000175

3'-5'-exoribonuclease activity

SGD_REF:S000069437
PMID:11889048[3]

IMP: Inferred from Mutant Phenotype

F

From SGD

GO:0000288

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

SGD_REF:S000069437
PMID:11889048[3]

IDA: Inferred from Direct Assay

P

From SGD

GO:0000288

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

SGD_REF:S000069437
PMID:11889048[3]

IGI: Inferred from Genetic Interaction

P

From SGD

GO:0000288

nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

SGD_REF:S000069437
PMID:11889048[3]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0000289

nuclear-transcribed mRNA poly(A) tail shortening

SGD_REF:S000069437
PMID:11889048[3]

IDA: Inferred from Direct Assay

P

From SGD

GO:0000289

nuclear-transcribed mRNA poly(A) tail shortening

SGD_REF:S000073816
PMID:11410650[4]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0000289

nuclear-transcribed mRNA poly(A) tail shortening

SGD_REF:S000120021
PMID:17158920[1]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0000932

cytoplasmic mRNA processing body

SGD_REF:S000126986
PMID:18611963[5]

IDA: Inferred from Direct Assay

C

From SGD

GO:0003723

RNA binding

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0694

F

From SGD

GO:0004518

nuclease activity

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0540

F

From SGD

GO:0004527

exonuclease activity

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0269

F

From SGD

GO:0004535

poly(A)-specific ribonuclease activity

SGD_REF:S000124037

IEA: Inferred from Electronic Annotation

EC:3.1.13.4

F

From SGD

GO:0005634

nucleus

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

From SGD

GO:0005634

nucleus

SGD_REF:S000148671

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

From SGD

GO:0005737

cytoplasm

SGD_REF:S000069437
PMID:11889048[3]

IDA: Inferred from Direct Assay

C

From SGD

GO:0005737

cytoplasm

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

From SGD

GO:0005737

cytoplasm

SGD_REF:S000148671

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

From SGD

GO:0006260

DNA replication

SGD_REF:S000120021
PMID:17158920[1]

IGI: Inferred from Genetic Interaction

SGD:S000003804
SGD:S000001447
SGD:S000001596
SGD:S000005670

P

From SGD

GO:0006351

transcription, DNA-dependent

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

From SGD

GO:0006355

regulation of transcription, DNA-dependent

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

From SGD

GO:0006357

regulation of transcription from RNA polymerase II promoter

SGD_REF:S000042122
PMID:10490603[6]

IPI: Inferred from Physical Interaction

P

From SGD

GO:0006368

transcription elongation from RNA polymerase II promoter

SGD_REF:S000074806
PMID:11404327[7]

IGI: Inferred from Genetic Interaction

SGD:S000003011
SGD:S000002299
SGD:S000005677
SGD:S000004470

P

From SGD

GO:0006368

transcription elongation from RNA polymerase II promoter

SGD_REF:S000074806
PMID:11404327[7]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0007089

traversing start control point of mitotic cell cycle

SGD_REF:S000076054
PMID:15075273[8]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0016787

hydrolase activity

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0378

F

From SGD

GO:0030015

CCR4-NOT core complex

SGD_REF:S000042122
PMID:10490603[6]

IPI: Inferred from Physical Interaction

C

From SGD

GO:0032968

positive regulation of transcription elongation from RNA polymerase II promoter

SGD_REF:S000145305
PMID:21406554[9]

IDA: Inferred from Direct Assay

P

From SGD

GO:0032968

positive regulation of transcription elongation from RNA polymerase II promoter

SGD_REF:S000145305
PMID:21406554[9]

IPI: Inferred from Physical Interaction

SGD:S000002299

P

From SGD

GO:0046872

metal ion binding

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

From SGD

GO:0048478

replication fork protection

SGD_REF:S000120021
PMID:17158920[1]

IGI: Inferred from Genetic Interaction

SGD:S000002259

P

From SGD

GO:0090305

nucleic acid phosphodiester bond hydrolysis

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0540

P

From SGD

colocalizes_with

GO:0016593

Cdc73/Paf1 complex

SGD_REF:S000041293
PMID:9891041[10]

IPI: Inferred from Physical Interaction

SGD:S000004410

C

From SGD


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 1.3 Woolstencroft, RN et al. (2006) Ccr4 contributes to tolerance of replication stress through control of CRT1 mRNA poly(A) tail length. J. Cell. Sci. 119 5178-92 PubMed GONUTS page
  2. Tucker, M et al. (2001) The transcription factor associated Ccr4 and Caf1 proteins are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiae. Cell 104 377-86 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Tucker, M et al. (2002) Ccr4p is the catalytic subunit of a Ccr4p/Pop2p/Notp mRNA deadenylase complex in Saccharomyces cerevisiae. EMBO J. 21 1427-36 PubMed GONUTS page
  4. Daugeron, MC et al. (2001) The yeast POP2 gene encodes a nuclease involved in mRNA deadenylation. Nucleic Acids Res. 29 2448-55 PubMed GONUTS page
  5. Reijns, MA et al. (2008) A role for Q/N-rich aggregation-prone regions in P-body localization. J. Cell. Sci. 121 2463-72 PubMed GONUTS page
  6. 6.0 6.1 Bai, Y et al. (1999) The CCR4 and CAF1 proteins of the CCR4-NOT complex are physically and functionally separated from NOT2, NOT4, and NOT5. Mol. Cell. Biol. 19 6642-51 PubMed GONUTS page
  7. 7.0 7.1 Denis, CL et al. (2001) Genetic evidence supports a role for the yeast CCR4-NOT complex in transcriptional elongation. Genetics 158 627-34 PubMed GONUTS page
  8. Westmoreland, TJ et al. (2004) Cell cycle progression in G1 and S phases is CCR4 dependent following ionizing radiation or replication stress in Saccharomyces cerevisiae. Eukaryotic Cell 3 430-46 PubMed GONUTS page
  9. 9.0 9.1 Kruk, JA et al. (2011) The multifunctional Ccr4-Not complex directly promotes transcription elongation. Genes Dev. 25 581-93 PubMed GONUTS page
  10. Chang, M et al. (1999) A complex containing RNA polymerase II, Paf1p, Cdc73p, Hpr1p, and Ccr4p plays a role in protein kinase C signaling. Mol. Cell. Biol. 19 1056-67 PubMed GONUTS page
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