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SGD:AUR1

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Species (Taxon ID) Saccharomyces cerevisiae (baker's yeast) (taxon:4932)
Gene Name(s) AUR1 ( synonyms: YKL004W, inositol phosphorylceramide synthase )
Protein Name(s) Phosphatidylinositol:ceramide phosphoinositol transferase,
External Links
SGD S000001487

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0003824

catalytic activity

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR016118
InterPro:IPR000326

F

From SGD

GO:0005794

Golgi apparatus

SGD_REF:S000039304
PMID:10888667[1]

IDA: Inferred from Direct Assay

C

From SGD

GO:0005794

Golgi apparatus

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0333

C

From SGD

GO:0006629

lipid metabolic process

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0443

P

From SGD

GO:0006665

sphingolipid metabolic process

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0746

P

From SGD

GO:0006673

inositolphosphoceramide metabolic process

SGD_REF:S000131445
PMID:19726565[2]

IDA: Inferred from Direct Assay

P

From SGD

GO:0016020

membrane

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR000326

C

From SGD

GO:0016020

membrane

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

From SGD

GO:0016021

integral to membrane

SGD_REF:S000114049
PMID:12192589[3]

ISM: Inferred from Sequence Model

C

From SGD

GO:0016021

integral to membrane

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

From SGD

GO:0016740

transferase activity

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

From SGD

GO:0030148

sphingolipid biosynthetic process

SGD_REF:S000053853
PMID:9092515[4]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0032580

Golgi cisterna membrane

SGD_REF:S000148671

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0136

C

From SGD

GO:0045140

inositol phosphoceramide synthase activity

SGD_REF:S000053853
PMID:9092515[4]

IMP: Inferred from Mutant Phenotype

F

From SGD

GO:0045140

inositol phosphoceramide synthase activity

SGD_REF:S000128562
PMID:19047657[5]

IDA: Inferred from Direct Assay

F

From SGD

GO:0070916

inositol phosphoceramide synthase complex

SGD_REF:S000131445
PMID:19726565[2]

IPI: Inferred from Physical Interaction

SGD:S000002775

C

From SGD


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Levine, TP et al. (2000) Inositol phosphorylceramide synthase is located in the Golgi apparatus of Saccharomyces cerevisiae. Mol. Biol. Cell 11 2267-81 PubMed GONUTS page
  2. 2.0 2.1 Sato, K et al. (2009) Kei1: a novel subunit of inositolphosphorylceramide synthase, essential for its enzyme activity and Golgi localization. Mol. Biol. Cell 20 4444-57 PubMed GONUTS page
  3. De Hertogh, B et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct. Integr. Genomics 2 154-70 PubMed GONUTS page
  4. 4.0 4.1 Nagiec, MM et al. (1997) Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene. J. Biol. Chem. 272 9809-17 PubMed GONUTS page
  5. Aeed, PA et al. (2009) Inhibition of inositol phosphorylceramide synthase by the cyclic peptide aureobasidin A. Antimicrob. Agents Chemother. 53 496-504 PubMed GONUTS page
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