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SGD:ATP1

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Species (Taxon ID) Saccharomyces cerevisiae (baker's yeast) (taxon:4932)
Gene Name(s) ATP1 ( synonyms: YBL099W, F1F0 ATP synthase subunit alpha )
Protein Name(s) Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase,
External Links
SGD S000000195

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

From SGD

GO:0005524

ATP binding

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR020003
InterPro:IPR000194

F

From SGD

GO:0005524

ATP binding

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

From SGD

GO:0005739

mitochondrion

SGD_REF:S000068875
PMID:11502169[1]

IDA: Inferred from Direct Assay

C

From SGD

GO:0005739

mitochondrion

SGD_REF:S000117178
PMID:16823961[2]

IDA: Inferred from Direct Assay

C

From SGD

GO:0005739

mitochondrion

SGD_REF:S000118886
PMID:16962558[3]

IPI: Inferred from Physical Interaction

SGD:S000001217
SGD:S000003486

C

From SGD

GO:0005739

mitochondrion

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0496

C

From SGD

GO:0005743

mitochondrial inner membrane

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0999

C

From SGD

GO:0005743

mitochondrial inner membrane

SGD_REF:S000148671

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0168

C

From SGD

GO:0005754

mitochondrial proton-transporting ATP synthase, catalytic core

SGD_REF:S000042736
PMID:2876995[4]

IMP: Inferred from Mutant Phenotype

C

From SGD

GO:0005754

mitochondrial proton-transporting ATP synthase, catalytic core

SGD_REF:S000042736
PMID:2876995[4]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P00823

C

From SGD

GO:0005754

mitochondrial proton-transporting ATP synthase, catalytic core

SGD_REF:S000119486
PMID:17082766[5]

IDA: Inferred from Direct Assay

C

From SGD

GO:0006754

ATP biosynthetic process

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0066

P

From SGD

GO:0006810

transport

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0813

P

From SGD

GO:0006811

ion transport

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0406

P

From SGD

GO:0015986

ATP synthesis coupled proton transport

SGD_REF:S000042736
PMID:2876995[4]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0015986

ATP synthesis coupled proton transport

SGD_REF:S000042736
PMID:2876995[4]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P00823

P

From SGD

GO:0015986

ATP synthesis coupled proton transport

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR005294

P

From SGD

GO:0015986

ATP synthesis coupled proton transport

SGD_REF:S000135617
PMID:20691145[6]

IDA: Inferred from Direct Assay

P

From SGD

GO:0015991

ATP hydrolysis coupled proton transport

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR000793

P

From SGD

GO:0015992

proton transport

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR004100
InterPro:IPR018118

P

From SGD

GO:0015992

proton transport

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0375

P

From SGD

GO:0016020

membrane

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

From SGD

GO:0016021

integral to membrane

SGD_REF:S000114049
PMID:12192589[7]

ISM: Inferred from Sequence Model

C

From SGD

GO:0016469

proton-transporting two-sector ATPase complex

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR004100
InterPro:IPR018118

C

From SGD

GO:0016820

hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR000793

F

From SGD

GO:0033178

proton-transporting two-sector ATPase complex, catalytic domain

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR000793

C

From SGD

GO:0042645

mitochondrial nucleoid

SGD_REF:S000050870
PMID:10869431[8]

IDA: Inferred from Direct Assay

C

From SGD

GO:0045261

proton-transporting ATP synthase complex, catalytic core F(1)

SGD_REF:S000077226
PMID:15294286[9]

IDA: Inferred from Direct Assay

C

From SGD

GO:0045261

proton-transporting ATP synthase complex, catalytic core F(1)

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR005294

C

From SGD

GO:0045261

proton-transporting ATP synthase complex, catalytic core F(1)

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0139

C

From SGD

GO:0046034

ATP metabolic process

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR004100
InterPro:IPR018118

P

From SGD

GO:0046933

hydrogen ion transporting ATP synthase activity, rotational mechanism

SGD_REF:S000042736
PMID:2876995[4]

ISS: Inferred from Sequence or Structural Similarity

UniProtKB:P00823

F

From SGD

GO:0046933

hydrogen ion transporting ATP synthase activity, rotational mechanism

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR004100
InterPro:IPR005294
InterPro:IPR018118

F

From SGD

GO:0046961

proton-transporting ATPase activity, rotational mechanism

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR005294
InterPro:IPR004100
InterPro:IPR018118

F

From SGD

contributes_to

GO:0016887

ATPase activity

SGD_REF:S000127601
PMID:18722382[10]

IDA: Inferred from Direct Assay

F

From SGD

contributes_to

GO:0046933

hydrogen ion transporting ATP synthase activity, rotational mechanism

SGD_REF:S000042736
PMID:2876995[4]

IMP: Inferred from Mutant Phenotype

F

From SGD

contributes_to

GO:0046933

hydrogen ion transporting ATP synthase activity, rotational mechanism

SGD_REF:S000077226
PMID:15294286[9]

IDA: Inferred from Direct Assay

F

From SGD

contributes_to

GO:0046933

hydrogen ion transporting ATP synthase activity, rotational mechanism

SGD_REF:S000116446
PMID:1827117[11]

IMP: Inferred from Mutant Phenotype

F

From SGD

contributes_to

GO:0046961

proton-transporting ATPase activity, rotational mechanism

SGD_REF:S000135617
PMID:20691145[6]

IDA: Inferred from Direct Assay

F

From SGD


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Grandier-Vazeille, X et al. (2001) Yeast mitochondrial dehydrogenases are associated in a supramolecular complex. Biochemistry 40 9758-69 PubMed GONUTS page
  2. Reinders, J et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J. Proteome Res. 5 1543-54 PubMed GONUTS page
  3. Brandina, I et al. () Enolase takes part in a macromolecular complex associated to mitochondria in yeast. Biochim. Biophys. Acta 1757 1217-28 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 Takeda, M et al. (1986) Nuclear genes encoding the yeast mitochondrial ATPase complex. Analysis of ATP1 coding the F1-ATPase alpha-subunit and its assembly. J. Biol. Chem. 261 15126-33 PubMed GONUTS page
  5. Kabaleeswaran, V et al. (2006) Novel features of the rotary catalytic mechanism revealed in the structure of yeast F1 ATPase. EMBO J. 25 5433-42 PubMed GONUTS page
  6. 6.0 6.1 Förster, K et al. (2010) Proton transport coupled ATP synthesis by the purified yeast H+ -ATP synthase in proteoliposomes. Biochim. Biophys. Acta 1797 1828-37 PubMed GONUTS page
  7. De Hertogh, B et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct. Integr. Genomics 2 154-70 PubMed GONUTS page
  8. Kaufman, BA et al. (2000) In organello formaldehyde crosslinking of proteins to mtDNA: identification of bifunctional proteins. Proc. Natl. Acad. Sci. U.S.A. 97 7772-7 PubMed GONUTS page
  9. 9.0 9.1 Ichikawa, N & Mizuno, M (2004) Functional expression of hexahistidine-tagged beta-subunit of yeast F1-ATPase and isolation of the enzyme by immobilized metal affinity chromatography. Protein Expr. Purif. 37 97-101 PubMed GONUTS page
  10. Lau, WC et al. (2008) Cryo-EM structure of the yeast ATP synthase. J. Mol. Biol. 382 1256-64 PubMed GONUTS page
  11. Jault, JM et al. (1991) Alteration of apparent negative cooperativity of ATPase activity by alpha-subunit glutamine 173 mutation in yeast mitochondrial F1. Correlation with impaired nucleotide interaction at a regulatory site. J. Biol. Chem. 266 8073-8 PubMed GONUTS page
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