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SGD:ATG8

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Species (Taxon ID) Saccharomyces cerevisiae (baker's yeast) (taxon:4932)
Gene Name(s) ATG8 ( synonyms: YBL078C, APG8, AUT7, CVT5 )
Protein Name(s) Component of autophagosomes and Cvt vesicles,
External Links
SGD S000000174

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000045

autophagic vacuole assembly

SGD_REF:S000059843
PMID:11149920[1]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0000329

fungal-type vacuole membrane

SGD_REF:S000056423
PMID:10837468[2]

IDA: Inferred from Direct Assay

C

From SGD

GO:0000329

fungal-type vacuole membrane

SGD_REF:S000056423
PMID:10837468[2]

IPI: Inferred from Physical Interaction

SGD:S000004083

C

From SGD

GO:0000407

pre-autophagosomal structure

SGD_REF:S000068967
PMID:11689437[3]

IDA: Inferred from Direct Assay

C

From SGD

GO:0000407

pre-autophagosomal structure

SGD_REF:S000086257
PMID:15659643[4]

IDA: Inferred from Direct Assay

C

From SGD

GO:0000407

pre-autophagosomal structure

SGD_REF:S000115787
PMID:16680092[5]

IDA: Inferred from Direct Assay

C

From SGD

GO:0000421

autophagic vacuole membrane

SGD_REF:S000148671

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0022

C

From SGD

GO:0000422

mitochondrion degradation

SGD_REF:S000132617
PMID:19793921[6]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0003674

molecular function

SGD_REF:S000069584

ND: No biological Data available

F

From SGD

GO:0005773

vacuole

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0926

C

From SGD

GO:0005774

vacuolar membrane

SGD_REF:S000148671

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0271

C

From SGD

GO:0005776

autophagic vacuole

SGD_REF:S000049668
PMID:10525546[7]

IDA: Inferred from Direct Assay

C

From SGD

GO:0005776

autophagic vacuole

SGD_REF:S000059843
PMID:11149920[1]

IDA: Inferred from Direct Assay

C

From SGD

GO:0005776

autophagic vacuole

SGD_REF:S000086066
PMID:16079147[8]

IDA: Inferred from Direct Assay

C

From SGD

GO:0005829

cytosol

SGD_REF:S000059843
PMID:11149920[1]

IDA: Inferred from Direct Assay

C

From SGD

GO:0006810

transport

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0813

P

From SGD

GO:0006888

ER to Golgi vesicle-mediated transport

SGD_REF:S000056423
PMID:10837468[2]

IGI: Inferred from Genetic Interaction

SGD:S000001266

P

From SGD

GO:0006888

ER to Golgi vesicle-mediated transport

SGD_REF:S000056423
PMID:10837468[2]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0006888

ER to Golgi vesicle-mediated transport

SGD_REF:S000056423
PMID:10837468[2]

IPI: Inferred from Physical Interaction

SGD:S000001266

P

From SGD

GO:0006914

autophagy

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0072

P

From SGD

GO:0006944

cellular membrane fusion

SGD_REF:S000123418
PMID:17632063[9]

IDA: Inferred from Direct Assay

P

From SGD

GO:0006944

cellular membrane fusion

SGD_REF:S000123418
PMID:17632063[9]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0015031

protein transport

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0653

P

From SGD

GO:0016020

membrane

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

From SGD

GO:0019898

extrinsic to membrane

SGD_REF:S000056423
PMID:10837468[2]

IDA: Inferred from Direct Assay

C

From SGD

GO:0031410

cytoplasmic vesicle

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0968

C

From SGD

GO:0032258

CVT pathway

SGD_REF:S000046683
PMID:9649430[10]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0033110

CVT vesicle membrane

SGD_REF:S000148671

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0081

C

From SGD

GO:0034727

piecemeal microautophagy of nucleus

SGD_REF:S000127377
PMID:18701704[11]

IMP: Inferred from Mutant Phenotype

P

From SGD


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 Kim, J et al. (2001) Membrane recruitment of Aut7p in the autophagy and cytoplasm to vacuole targeting pathways requires Aut1p, Aut2p, and the autophagy conjugation complex. J. Cell Biol. 152 51-64 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 Legesse-Miller, A et al. (2000) Aut7p, a soluble autophagic factor, participates in multiple membrane trafficking processes. J. Biol. Chem. 275 32966-73 PubMed GONUTS page
  3. Suzuki, K et al. (2001) The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation. EMBO J. 20 5971-81 PubMed GONUTS page
  4. Yorimitsu, T & Klionsky, DJ (2005) Atg11 links cargo to the vesicle-forming machinery in the cytoplasm to vacuole targeting pathway. Mol. Biol. Cell 16 1593-605 PubMed GONUTS page
  5. Amar, N et al. (2006) Two newly identified sites in the ubiquitin-like protein Atg8 are essential for autophagy. EMBO Rep. 7 635-42 PubMed GONUTS page
  6. Kanki, T et al. (2009) A genomic screen for yeast mutants defective in selective mitochondria autophagy. Mol. Biol. Cell 20 4730-8 PubMed GONUTS page
  7. Kirisako, T et al. (1999) Formation process of autophagosome is traced with Apg8/Aut7p in yeast. J. Cell Biol. 147 435-46 PubMed GONUTS page
  8. Meiling-Wesse, K et al. (2005) Trs85 (Gsg1), a component of the TRAPP complexes, is required for the organization of the preautophagosomal structure during selective autophagy via the Cvt pathway. J. Biol. Chem. 280 33669-78 PubMed GONUTS page
  9. 9.0 9.1 Nakatogawa, H et al. (2007) Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion. Cell 130 165-78 PubMed GONUTS page
  10. Lang, T et al. (1998) Aut2p and Aut7p, two novel microtubule-associated proteins are essential for delivery of autophagic vesicles to the vacuole. EMBO J. 17 3597-607 PubMed GONUTS page
  11. Krick, R et al. (2008) Piecemeal microautophagy of the nucleus requires the core macroautophagy genes. Mol. Biol. Cell 19 4492-505 PubMed GONUTS page
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