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SGD:ATG7

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Species (Taxon ID) Saccharomyces cerevisiae (baker's yeast) (taxon:4932)
Gene Name(s) ATG7 ( synonyms: YHR171W, APG11, APG7, CVT2 )
Protein Name(s) Autophagy-related protein and dual specificity member of the E1 family,
External Links
SGD S000001214

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR016040

F

From SGD

GO:0000407

pre-autophagosomal structure

SGD_REF:S000126495
PMID:18497569[1]

IDA: Inferred from Direct Assay

C

From SGD

GO:0000422

mitochondrion degradation

SGD_REF:S000132617
PMID:19793921[2]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0003824

catalytic activity

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR000594

F

From SGD

GO:0005737

cytoplasm

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR006285

C

From SGD

GO:0005737

cytoplasm

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

From SGD

GO:0005737

cytoplasm

SGD_REF:S000148671

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

From SGD

GO:0005739

mitochondrion

SGD_REF:S000075100
PMID:14576278[3]

IDA: Inferred from Direct Assay

C

From SGD

GO:0005739

mitochondrion

SGD_REF:S000117178
PMID:16823961[4]

IDA: Inferred from Direct Assay

C

From SGD

GO:0005829

cytosol

SGD_REF:S000048125
PMID:10233150[5]

IDA: Inferred from Direct Assay

C

From SGD

GO:0006501

C-terminal protein lipidation

SGD_REF:S000059720
PMID:11100732[6]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0006501

C-terminal protein lipidation

SGD_REF:S000059897
PMID:11038174[7]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0006501

C-terminal protein lipidation

SGD_REF:S000073971
PMID:12965207[8]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0006501

C-terminal protein lipidation

SGD_REF:S000077450
PMID:15277523[9]

IDA: Inferred from Direct Assay

P

From SGD

GO:0006501

C-terminal protein lipidation

SGD_REF:S000077450
PMID:15277523[9]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0006810

transport

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0813

P

From SGD

GO:0006914

autophagy

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR006285

P

From SGD

GO:0006914

autophagy

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0072

P

From SGD

GO:0015031

protein transport

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0653

P

From SGD

GO:0016020

membrane

SGD_REF:S000048111
PMID:10233148[10]

IDA: Inferred from Direct Assay

C

From SGD

GO:0016236

macroautophagy

SGD_REF:S000048125
PMID:10233150[5]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0016236

macroautophagy

SGD_REF:S000073971
PMID:12965207[8]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0019778

APG12 activating enzyme activity

SGD_REF:S000048125
PMID:10233150[5]

IMP: Inferred from Mutant Phenotype

F

From SGD

GO:0019778

APG12 activating enzyme activity

SGD_REF:S000048125
PMID:10233150[5]

IPI: Inferred from Physical Interaction

SGD:S000000421

F

From SGD

GO:0019779

APG8 activating enzyme activity

SGD_REF:S000059720
PMID:11100732[6]

IMP: Inferred from Mutant Phenotype

F

From SGD

GO:0019779

APG8 activating enzyme activity

SGD_REF:S000059720
PMID:11100732[6]

IPI: Inferred from Physical Interaction

SGD:S000000174

F

From SGD

GO:0032258

CVT pathway

SGD_REF:S000048125
PMID:10233150[5]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0032258

CVT pathway

SGD_REF:S000073971
PMID:12965207[8]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0032446

protein modification by small protein conjugation

SGD_REF:S000048125
PMID:10233150[5]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0034727

piecemeal microautophagy of nucleus

SGD_REF:S000127377
PMID:18701704[11]

IMP: Inferred from Mutant Phenotype

P

From SGD


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Ma, J et al. (2008) Localization of autophagy-related proteins in yeast using a versatile plasmid-based resource of fluorescent protein fusions. Autophagy 4 792-800 PubMed GONUTS page
  2. Kanki, T et al. (2009) A genomic screen for yeast mutants defective in selective mitochondria autophagy. Mol. Biol. Cell 20 4730-8 PubMed GONUTS page
  3. Sickmann, A et al. (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc. Natl. Acad. Sci. U.S.A. 100 13207-12 PubMed GONUTS page
  4. Reinders, J et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J. Proteome Res. 5 1543-54 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 5.5 Tanida, I et al. (1999) Apg7p/Cvt2p: A novel protein-activating enzyme essential for autophagy. Mol. Biol. Cell 10 1367-79 PubMed GONUTS page
  6. 6.0 6.1 6.2 Ichimura, Y et al. (2000) A ubiquitin-like system mediates protein lipidation. Nature 408 488-92 PubMed GONUTS page
  7. Kirisako, T et al. (2000) The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway. J. Cell Biol. 151 263-76 PubMed GONUTS page
  8. 8.0 8.1 8.2 Yamazaki-Sato, H et al. (2003) The carboxyl terminal 17 amino acids within Apg7 are essential for Apg8 lipidation, but not for Apg12 conjugation. FEBS Lett. 551 71-7 PubMed GONUTS page
  9. 9.0 9.1 Ichimura, Y et al. (2004) In vivo and in vitro reconstitution of Atg8 conjugation essential for autophagy. J. Biol. Chem. 279 40584-92 PubMed GONUTS page
  10. Kim, J et al. (1999) Apg7p/Cvt2p is required for the cytoplasm-to-vacuole targeting, macroautophagy, and peroxisome degradation pathways. Mol. Biol. Cell 10 1337-51 PubMed GONUTS page
  11. Krick, R et al. (2008) Piecemeal microautophagy of the nucleus requires the core macroautophagy genes. Mol. Biol. Cell 19 4492-505 PubMed GONUTS page
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