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SGD:ATG14

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Species (Taxon ID) Saccharomyces cerevisiae (baker's yeast) (taxon:4932)
Gene Name(s) ATG14 ( synonyms: YBR128C, APG14, CVT12 )
Protein Name(s) Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I,
External Links
SGD S000000332

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000329

fungal-type vacuole membrane

SGD_REF:S000114166
PMID:16421251[1]

IDA: Inferred from Direct Assay

C

From SGD

GO:0000407

pre-autophagosomal structure

SGD_REF:S000114166
PMID:16421251[1]

IDA: Inferred from Direct Assay

C

From SGD

GO:0006810

transport

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0813

P

From SGD

GO:0006914

autophagy

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0072

P

From SGD

GO:0010508

positive regulation of autophagy

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR018791

P

From SGD

GO:0015031

protein transport

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0653

P

From SGD

GO:0016020

membrane

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

From SGD

GO:0016020

membrane

SGD_REF:S000148671

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0162

C

From SGD

GO:0016236

macroautophagy

SGD_REF:S000050199
PMID:9712845[2]

IGI: Inferred from Genetic Interaction

SGD:S000006041

P

From SGD

GO:0016236

macroautophagy

SGD_REF:S000050199
PMID:9712845[2]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0016236

macroautophagy

SGD_REF:S000059475
PMID:11157979[3]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0019898

extrinsic to membrane

SGD_REF:S000050199
PMID:9712845[2]

IDA: Inferred from Direct Assay

C

From SGD

GO:0030242

peroxisome degradation

SGD_REF:S000141169
PMID:21121900[4]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0030433

ER-associated protein catabolic process

SGD_REF:S000113639
PMID:16267277[5]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0032258

CVT pathway

SGD_REF:S000057982
PMID:8901576[6]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0034271

phosphatidylinositol 3-kinase complex I

SGD_REF:S000059475
PMID:11157979[3]

IDA: Inferred from Direct Assay

C

From SGD

GO:0034727

piecemeal microautophagy of nucleus

SGD_REF:S000127377
PMID:18701704[7]

IMP: Inferred from Mutant Phenotype

P

From SGD

contributes_to

GO:0016303

1-phosphatidylinositol-3-kinase activity

SGD_REF:S000114166
PMID:16421251[1]

IPI: Inferred from Physical Interaction

SGD:S000006041
SGD:S000004230

F

From SGD


Notes

References

See Help:References for how to manage references in GONUTS.
  1. 1.0 1.1 1.2 Obara, K et al. (2006) Assortment of phosphatidylinositol 3-kinase complexes--Atg14p directs association of complex I to the pre-autophagosomal structure in Saccharomyces cerevisiae. Mol. Biol. Cell 17 1527-39 PubMed GONUTS page
  2. 2.0 2.1 2.2 Kametaka, S et al. (1998) Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae. J. Biol. Chem. 273 22284-91 PubMed GONUTS page
  3. 3.0 3.1 Kihara, A et al. (2001) Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J. Cell Biol. 152 519-30 PubMed GONUTS page
  4. Grunau, S et al. (2011) The phosphoinositide 3-kinase Vps34p is required for pexophagy in Saccharomyces cerevisiae. Biochem. J. 434 161-70 PubMed GONUTS page
  5. Kruse, KB et al. (2006) Characterization of an ERAD gene as VPS30/ATG6 reveals two alternative and functionally distinct protein quality control pathways: one for soluble Z variant of human alpha-1 proteinase inhibitor (A1PiZ) and another for aggregates of A1PiZ. Mol. Biol. Cell 17 203-12 PubMed GONUTS page
  6. Scott, SV et al. (1996) Cytoplasm-to-vacuole targeting and autophagy employ the same machinery to deliver proteins to the yeast vacuole. Proc. Natl. Acad. Sci. U.S.A. 93 12304-8 PubMed GONUTS page
  7. Krick, R et al. (2008) Piecemeal microautophagy of the nucleus requires the core macroautophagy genes. Mol. Biol. Cell 19 4492-505 PubMed GONUTS page
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