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SGD:ATG12

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Species (Taxon ID) Saccharomyces cerevisiae (baker's yeast) (taxon:4932)
Gene Name(s) ATG12 ( synonyms: YBR217W, APG12 )
Protein Name(s) Ubiquitin-like modifier involved in autophagy and the Cvt pathway,
External Links
SGD S000000421

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000045

autophagic vacuole assembly

SGD_REF:S000117725
PMID:16874032[1]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0000045

autophagic vacuole assembly

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR007242

P

From SGD

GO:0000407

pre-autophagosomal structure

SGD_REF:S000069879
PMID:11897782[2]

IC: Inferred by Curator

GO:0034274

C

From SGD

GO:0000422

mitochondrion degradation

SGD_REF:S000132617
PMID:19793921[3]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0005737

cytoplasm

SGD_REF:S000124036

IEA: Inferred from Electronic Annotation

InterPro:IPR007242

C

From SGD

GO:0005737

cytoplasm

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

From SGD

GO:0005737

cytoplasm

SGD_REF:S000148671

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

From SGD

GO:0006501

C-terminal protein lipidation

SGD_REF:S000124888
PMID:17986448[4]

IDA: Inferred from Direct Assay

P

From SGD

GO:0006810

transport

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0813

P

From SGD

GO:0006914

autophagy

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0072

P

From SGD

GO:0015031

protein transport

SGD_REF:S000148669

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0653

P

From SGD

GO:0031386

protein tag

SGD_REF:S000039962
PMID:9759731[5]

IPI: Inferred from Physical Interaction

SGD:S000006070

F

From SGD

GO:0031386

protein tag

SGD_REF:S000045627
PMID:10508157[6]

IPI: Inferred from Physical Interaction

SGD:S000003965

F

From SGD

GO:0031386

protein tag

SGD_REF:S000048125
PMID:10233150[7]

IPI: Inferred from Physical Interaction

SGD:S000001214

F

From SGD

GO:0032258

CVT pathway

SGD_REF:S000039962
PMID:9759731[5]

IMP: Inferred from Mutant Phenotype

P

From SGD

GO:0034274

Atg12-Atg5-Atg16 complex

SGD_REF:S000069879
PMID:11897782[2]

IDA: Inferred from Direct Assay

C

From SGD

GO:0034727

piecemeal microautophagy of nucleus

SGD_REF:S000127377
PMID:18701704[8]

IMP: Inferred from Mutant Phenotype

P

From SGD

contributes_to

GO:0019776

Atg8 ligase activity

SGD_REF:S000124888
PMID:17986448[4]

IDA: Inferred from Direct Assay

F

From SGD


Notes

References

See Help:References for how to manage references in GONUTS.
  1. Hanada, T & Ohsumi, Y (2005) Structure-function relationship of Atg12, a ubiquitin-like modifier essential for autophagy. Autophagy 1 110-8 PubMed GONUTS page
  2. 2.0 2.1 Kuma, A et al. (2002) Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast. J. Biol. Chem. 277 18619-25 PubMed GONUTS page
  3. Kanki, T et al. (2009) A genomic screen for yeast mutants defective in selective mitochondria autophagy. Mol. Biol. Cell 20 4730-8 PubMed GONUTS page
  4. 4.0 4.1 Hanada, T et al. (2007) The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy. J. Biol. Chem. 282 37298-302 PubMed GONUTS page
  5. 5.0 5.1 Mizushima, N et al. (1998) A protein conjugation system essential for autophagy. Nature 395 395-8 PubMed GONUTS page
  6. Shintani, T et al. (1999) Apg10p, a novel protein-conjugating enzyme essential for autophagy in yeast. EMBO J. 18 5234-41 PubMed GONUTS page
  7. Tanida, I et al. (1999) Apg7p/Cvt2p: A novel protein-activating enzyme essential for autophagy. Mol. Biol. Cell 10 1367-79 PubMed GONUTS page
  8. Krick, R et al. (2008) Piecemeal microautophagy of the nucleus requires the core macroautophagy genes. Mol. Biol. Cell 19 4492-505 PubMed GONUTS page
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